Adipose inflammation: cause or consequence of obesity-related insulin resistance

Ping Jiao, Haiyan XuHallett Center for Diabetes and Endocrinology, Brown Medical School, Providence, RI, USAAbstract: Obesity constitutes a critical risk factor for the development of many life threatening diseases, particularly insulin resistance and type 2 diabetes. Adipose tissue plays an importa...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Haiyan Xu, Ping Jiao
Format:	article
Langue:	EN
Publié:	Dove Medical Press 2008
Sujets:	Specialties of internal medicine RC581-951
Accès en ligne:	https://doaj.org/article/cead96a54a744e218f9eafa2d1298de5
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

id	oai:doaj.org-article:cead96a54a744e218f9eafa2d1298de5
record_format	dspace
spelling	oai:doaj.org-article:cead96a54a744e218f9eafa2d1298de52021-12-02T01:45:50ZAdipose inflammation: cause or consequence of obesity-related insulin resistance1178-7007https://doaj.org/article/cead96a54a744e218f9eafa2d1298de52008-10-01T00:00:00Zhttp://www.dovepress.com/adipose-inflammation-cause-or-consequence-of-obesity-related-insulin-r-a2500https://doaj.org/toc/1178-7007Ping Jiao, Haiyan XuHallett Center for Diabetes and Endocrinology, Brown Medical School, Providence, RI, USAAbstract: Obesity constitutes a critical risk factor for the development of many life threatening diseases, particularly insulin resistance and type 2 diabetes. Adipose tissue plays an important role in regulating whole body energy homeostatsis and obesity-related insulin resistance. Inflammation has been commonly linked to insulin resistance. Recent studies demonstrated that adipose tissue is an important source for producing inflammatory molecules in the obese state, primarily due to accumulation of macrophages. Animal models deficient in key inflammatory molecules or with reduced adipose macrophage infiltration are protected from development of obesity-related insulin resistance. Repression of adipose inflammation may be a useful approach to ameliorate obesity-associated metabolic disorders.Keywords: adipose inflammation, insulin resistance, obesity Haiyan XuPing JiaoDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2008, Iss default, Pp 25-31 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Haiyan Xu Ping Jiao Adipose inflammation: cause or consequence of obesity-related insulin resistance
description	Ping Jiao, Haiyan XuHallett Center for Diabetes and Endocrinology, Brown Medical School, Providence, RI, USAAbstract: Obesity constitutes a critical risk factor for the development of many life threatening diseases, particularly insulin resistance and type 2 diabetes. Adipose tissue plays an important role in regulating whole body energy homeostatsis and obesity-related insulin resistance. Inflammation has been commonly linked to insulin resistance. Recent studies demonstrated that adipose tissue is an important source for producing inflammatory molecules in the obese state, primarily due to accumulation of macrophages. Animal models deficient in key inflammatory molecules or with reduced adipose macrophage infiltration are protected from development of obesity-related insulin resistance. Repression of adipose inflammation may be a useful approach to ameliorate obesity-associated metabolic disorders.Keywords: adipose inflammation, insulin resistance, obesity
format	article
author	Haiyan Xu Ping Jiao
author_facet	Haiyan Xu Ping Jiao
author_sort	Haiyan Xu
title	Adipose inflammation: cause or consequence of obesity-related insulin resistance
title_short	Adipose inflammation: cause or consequence of obesity-related insulin resistance
title_full	Adipose inflammation: cause or consequence of obesity-related insulin resistance
title_fullStr	Adipose inflammation: cause or consequence of obesity-related insulin resistance
title_full_unstemmed	Adipose inflammation: cause or consequence of obesity-related insulin resistance
title_sort	adipose inflammation: cause or consequence of obesity-related insulin resistance
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/cead96a54a744e218f9eafa2d1298de5
work_keys_str_mv	AT haiyanxu adiposeinflammationcauseorconsequenceofobesityrelatedinsulinresistance AT pingjiao adiposeinflammationcauseorconsequenceofobesityrelatedinsulinresistance
_version_	1718402924528271360

Adipose inflammation: cause or consequence of obesity-related insulin resistance

Documents similaires