TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration

Group migration of cranial neural crest cells depends upon Eph-ephrin signalling. Here, the authors show that TBC1d24 complexes with ephrinB2 via Dishevelled to induce contact inhibition of locomotion by reducing membrane E-cadherin. Eph receptor binding dissolves this complex and disrupts migration...

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Autores principales:	Jaeho Yoon, Yoo-Seok Hwang, Moonsup Lee, Jian Sun, Hee Jun Cho, Laura Knapik, Ira O. Daar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ceada544d7094d9595c7ca916ee61e29
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spelling	oai:doaj.org-article:ceada544d7094d9595c7ca916ee61e292021-12-02T17:31:14ZTBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration10.1038/s41467-018-05924-92041-1723https://doaj.org/article/ceada544d7094d9595c7ca916ee61e292018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05924-9https://doaj.org/toc/2041-1723Group migration of cranial neural crest cells depends upon Eph-ephrin signalling. Here, the authors show that TBC1d24 complexes with ephrinB2 via Dishevelled to induce contact inhibition of locomotion by reducing membrane E-cadherin. Eph receptor binding dissolves this complex and disrupts migration.Jaeho YoonYoo-Seok HwangMoonsup LeeJian SunHee Jun ChoLaura KnapikIra O. DaarNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jaeho Yoon Yoo-Seok Hwang Moonsup Lee Jian Sun Hee Jun Cho Laura Knapik Ira O. Daar TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration
description	Group migration of cranial neural crest cells depends upon Eph-ephrin signalling. Here, the authors show that TBC1d24 complexes with ephrinB2 via Dishevelled to induce contact inhibition of locomotion by reducing membrane E-cadherin. Eph receptor binding dissolves this complex and disrupts migration.
format	article
author	Jaeho Yoon Yoo-Seok Hwang Moonsup Lee Jian Sun Hee Jun Cho Laura Knapik Ira O. Daar
author_facet	Jaeho Yoon Yoo-Seok Hwang Moonsup Lee Jian Sun Hee Jun Cho Laura Knapik Ira O. Daar
author_sort	Jaeho Yoon
title	TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration
title_short	TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration
title_full	TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration
title_fullStr	TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration
title_full_unstemmed	TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration
title_sort	tbc1d24-ephrinb2 interaction regulates contact inhibition of locomotion in neural crest cell migration
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ceada544d7094d9595c7ca916ee61e29
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TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration

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