TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration

TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration

Group migration of cranial neural crest cells depends upon Eph-ephrin signalling. Here, the authors show that TBC1d24 complexes with ephrinB2 via Dishevelled to induce contact inhibition of locomotion by reducing membrane E-cadherin. Eph receptor binding dissolves this complex and disrupts migration...

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Autores principales: Jaeho Yoon, Yoo-Seok Hwang, Moonsup Lee, Jian Sun, Hee Jun Cho, Laura Knapik, Ira O. Daar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/ceada544d7094d9595c7ca916ee61e29
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