The brain’s structural differences between postherpetic neuralgia and lower back pain
Abstract The purpose is to explore the brain’s structural difference in local morphology and between-region networks between two types of peripheral neuropathic pain (PNP): postherpetic neuralgia (PHN) and lower back pain (LBP). A total of 54 participants including 38 LBP and 16 PHN patients were en...
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Nature Portfolio
2021
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oai:doaj.org-article:ceb1caffba3e47b5855378d254f82ca02021-11-21T12:20:12ZThe brain’s structural differences between postherpetic neuralgia and lower back pain10.1038/s41598-021-01915-x2045-2322https://doaj.org/article/ceb1caffba3e47b5855378d254f82ca02021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01915-xhttps://doaj.org/toc/2045-2322Abstract The purpose is to explore the brain’s structural difference in local morphology and between-region networks between two types of peripheral neuropathic pain (PNP): postherpetic neuralgia (PHN) and lower back pain (LBP). A total of 54 participants including 38 LBP and 16 PHN patients were enrolled. The average pain scores were 7.6 and 7.5 for LBP and PHN. High-resolution structural T1 weighted images were obtained. Both grey matter volume (GMV) and morphological connectivity (MC) were extracted. An independent two-sample t-test with false discovery rate (FDR) correction was used to identify the brain regions where LBP and PHN patients showed significant GMV difference. Next, we explored the differences of MC network between LBP and PHN patients and detected the group differences in network properties by using the two-sample t-test and FDR correction. Compared with PHN, LBP patients had significantly larger GMV in temporal gyrus, insula and fusiform gyrus (p < 0.05). The LBP cohort had significantly stronger MC in the connection between right precuneus and left opercular part of inferior frontal gyrus (p < 0.05). LBP patients had significantly stronger degree in left anterior cingulate gyrus and left rectus gyrus (p < 0.05) while had significantly weaker degree than PHN patients in left orbital part of middle frontal gyrus, left supplementary motor area and left superior parietal lobule (p < 0.05). LBP and PHN patients had significant differences in the brain’s GMV, MC, and network properties, which implies that different PNPs have different neural mechanisms concerning pain modulation.Jianxing QiuMengjiao DuJunzhe YangZengmao LinNaishan QinXiaowei SunLinling LiRushi ZouJuan WeiBing WuJing LiuZhiguo ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Jianxing Qiu Mengjiao Du Junzhe Yang Zengmao Lin Naishan Qin Xiaowei Sun Linling Li Rushi Zou Juan Wei Bing Wu Jing Liu Zhiguo Zhang The brain’s structural differences between postherpetic neuralgia and lower back pain |
| description |
Abstract The purpose is to explore the brain’s structural difference in local morphology and between-region networks between two types of peripheral neuropathic pain (PNP): postherpetic neuralgia (PHN) and lower back pain (LBP). A total of 54 participants including 38 LBP and 16 PHN patients were enrolled. The average pain scores were 7.6 and 7.5 for LBP and PHN. High-resolution structural T1 weighted images were obtained. Both grey matter volume (GMV) and morphological connectivity (MC) were extracted. An independent two-sample t-test with false discovery rate (FDR) correction was used to identify the brain regions where LBP and PHN patients showed significant GMV difference. Next, we explored the differences of MC network between LBP and PHN patients and detected the group differences in network properties by using the two-sample t-test and FDR correction. Compared with PHN, LBP patients had significantly larger GMV in temporal gyrus, insula and fusiform gyrus (p < 0.05). The LBP cohort had significantly stronger MC in the connection between right precuneus and left opercular part of inferior frontal gyrus (p < 0.05). LBP patients had significantly stronger degree in left anterior cingulate gyrus and left rectus gyrus (p < 0.05) while had significantly weaker degree than PHN patients in left orbital part of middle frontal gyrus, left supplementary motor area and left superior parietal lobule (p < 0.05). LBP and PHN patients had significant differences in the brain’s GMV, MC, and network properties, which implies that different PNPs have different neural mechanisms concerning pain modulation. |
| format |
article |
| author |
Jianxing Qiu Mengjiao Du Junzhe Yang Zengmao Lin Naishan Qin Xiaowei Sun Linling Li Rushi Zou Juan Wei Bing Wu Jing Liu Zhiguo Zhang |
| author_facet |
Jianxing Qiu Mengjiao Du Junzhe Yang Zengmao Lin Naishan Qin Xiaowei Sun Linling Li Rushi Zou Juan Wei Bing Wu Jing Liu Zhiguo Zhang |
| author_sort |
Jianxing Qiu |
| title |
The brain’s structural differences between postherpetic neuralgia and lower back pain |
| title_short |
The brain’s structural differences between postherpetic neuralgia and lower back pain |
| title_full |
The brain’s structural differences between postherpetic neuralgia and lower back pain |
| title_fullStr |
The brain’s structural differences between postherpetic neuralgia and lower back pain |
| title_full_unstemmed |
The brain’s structural differences between postherpetic neuralgia and lower back pain |
| title_sort |
brain’s structural differences between postherpetic neuralgia and lower back pain |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ceb1caffba3e47b5855378d254f82ca0 |
| work_keys_str_mv |
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