Detection of hydrogen peroxide with chemiluminescent micelles

Dongwon Lee1, Venkata R Erigala1,3, Madhuri Dasari1, Junhua Yu2, Robert M Dickson2, Niren Murthy11The Wallace H. Coulter Department of Biomedical Engineering; 2Department of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA; 3The Scripps Research Institute, La Jolla, CA,...

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Autores principales:	Dongwon Lee, Venkata R Erigala, Madhuri Dasari, Junhua Yu, Robert M Dickson, Niren Murthy
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ceb355e1549a412698bc9a7f90e41c5f
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spelling	oai:doaj.org-article:ceb355e1549a412698bc9a7f90e41c5f2021-12-02T05:39:38ZDetection of hydrogen peroxide with chemiluminescent micelles1176-91141178-2013https://doaj.org/article/ceb355e1549a412698bc9a7f90e41c5f2008-08-01T00:00:00Zhttp://www.dovepress.com/detection-of-hydrogen-peroxide-with-chemiluminescent-micelles-a1942https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Dongwon Lee1, Venkata R Erigala1,3, Madhuri Dasari1, Junhua Yu2, Robert M Dickson2, Niren Murthy11The Wallace H. Coulter Department of Biomedical Engineering; 2Department of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA; 3The Scripps Research Institute, La Jolla, CA, USAAbstract: The overproduction of hydrogen peroxide is implicated in the progress of numerous life-threatening diseases and there is a great need for the development of contrast agents that can detect hydrogen peroxide in vivo. In this communication, we present a new contrast agent for hydrogen peroxide, termed peroxalate micelles, which detect hydrogen peroxide through chemiluminescence, and have the physical/chemical properties needed for in vivo imaging applications. The peroxalate micelles are composed of amphiphilic peroxalate based copolymers and the fluorescent dye rubrene, they have a &lsquo;stealth&rsquo; polyethylene glycol (PEG) corona to evade macrophage phagocytosis, and a diameter of 33 nm to enhance extravasation into permeable tissues. The peroxalate micelles can detect nanomolar concentrations of hydrogen peroxide (&gt;50 nM) and thus have the sensitivity needed to detect physiological concentrations of hydrogen peroxide. We anticipate numerous applications of the peroxalate micelles for in vivo imaging of hydrogen peroxide, given their high sensitivity, small size, and biocompatible PEG corona.Keywords: hydrogen peroixde, chemiluminescence, micelles, amphiphilic copolymer Dongwon LeeVenkata R ErigalaMadhuri DasariJunhua YuRobert M DicksonNiren MurthyDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 4, Pp 471-476 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Dongwon Lee Venkata R Erigala Madhuri Dasari Junhua Yu Robert M Dickson Niren Murthy Detection of hydrogen peroxide with chemiluminescent micelles
description	Dongwon Lee1, Venkata R Erigala1,3, Madhuri Dasari1, Junhua Yu2, Robert M Dickson2, Niren Murthy11The Wallace H. Coulter Department of Biomedical Engineering; 2Department of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA; 3The Scripps Research Institute, La Jolla, CA, USAAbstract: The overproduction of hydrogen peroxide is implicated in the progress of numerous life-threatening diseases and there is a great need for the development of contrast agents that can detect hydrogen peroxide in vivo. In this communication, we present a new contrast agent for hydrogen peroxide, termed peroxalate micelles, which detect hydrogen peroxide through chemiluminescence, and have the physical/chemical properties needed for in vivo imaging applications. The peroxalate micelles are composed of amphiphilic peroxalate based copolymers and the fluorescent dye rubrene, they have a &lsquo;stealth&rsquo; polyethylene glycol (PEG) corona to evade macrophage phagocytosis, and a diameter of 33 nm to enhance extravasation into permeable tissues. The peroxalate micelles can detect nanomolar concentrations of hydrogen peroxide (&gt;50 nM) and thus have the sensitivity needed to detect physiological concentrations of hydrogen peroxide. We anticipate numerous applications of the peroxalate micelles for in vivo imaging of hydrogen peroxide, given their high sensitivity, small size, and biocompatible PEG corona.Keywords: hydrogen peroixde, chemiluminescence, micelles, amphiphilic copolymer
format	article
author	Dongwon Lee Venkata R Erigala Madhuri Dasari Junhua Yu Robert M Dickson Niren Murthy
author_facet	Dongwon Lee Venkata R Erigala Madhuri Dasari Junhua Yu Robert M Dickson Niren Murthy
author_sort	Dongwon Lee
title	Detection of hydrogen peroxide with chemiluminescent micelles
title_short	Detection of hydrogen peroxide with chemiluminescent micelles
title_full	Detection of hydrogen peroxide with chemiluminescent micelles
title_fullStr	Detection of hydrogen peroxide with chemiluminescent micelles
title_full_unstemmed	Detection of hydrogen peroxide with chemiluminescent micelles
title_sort	detection of hydrogen peroxide with chemiluminescent micelles
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/ceb355e1549a412698bc9a7f90e41c5f
work_keys_str_mv	AT dongwonlee detectionofhydrogenperoxidewithchemiluminescentmicelles AT venkatarerigala detectionofhydrogenperoxidewithchemiluminescentmicelles AT madhuridasari detectionofhydrogenperoxidewithchemiluminescentmicelles AT junhuayu detectionofhydrogenperoxidewithchemiluminescentmicelles AT robertmdickson detectionofhydrogenperoxidewithchemiluminescentmicelles AT nirenmurthy detectionofhydrogenperoxidewithchemiluminescentmicelles
_version_	1718400321979416576

Detection of hydrogen peroxide with chemiluminescent micelles

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