Rapid and reversible epigenome editing by endogenous chromatin regulators

Understanding the link between epigenetic marks and gene regulation requires the development of new tools to directly manipulate chromatin. Here the authors demonstrate a Cas9-based system to recruit chromatin remodelers to loci of interest, allowing rapid, reversible manipulation of epigenetic stat...

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Autores principales:	Simon M. G. Braun, Jacob G. Kirkland, Emma J. Chory, Dylan Husmann, Joseph P. Calarco, Gerald R. Crabtree
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ceb7020dd5784ed49c21a33809ac7893
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spelling	oai:doaj.org-article:ceb7020dd5784ed49c21a33809ac78932021-12-02T17:01:17ZRapid and reversible epigenome editing by endogenous chromatin regulators10.1038/s41467-017-00644-y2041-1723https://doaj.org/article/ceb7020dd5784ed49c21a33809ac78932017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00644-yhttps://doaj.org/toc/2041-1723Understanding the link between epigenetic marks and gene regulation requires the development of new tools to directly manipulate chromatin. Here the authors demonstrate a Cas9-based system to recruit chromatin remodelers to loci of interest, allowing rapid, reversible manipulation of epigenetic states.Simon M. G. BraunJacob G. KirklandEmma J. ChoryDylan HusmannJoseph P. CalarcoGerald R. CrabtreeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon M. G. Braun Jacob G. Kirkland Emma J. Chory Dylan Husmann Joseph P. Calarco Gerald R. Crabtree Rapid and reversible epigenome editing by endogenous chromatin regulators
description	Understanding the link between epigenetic marks and gene regulation requires the development of new tools to directly manipulate chromatin. Here the authors demonstrate a Cas9-based system to recruit chromatin remodelers to loci of interest, allowing rapid, reversible manipulation of epigenetic states.
format	article
author	Simon M. G. Braun Jacob G. Kirkland Emma J. Chory Dylan Husmann Joseph P. Calarco Gerald R. Crabtree
author_facet	Simon M. G. Braun Jacob G. Kirkland Emma J. Chory Dylan Husmann Joseph P. Calarco Gerald R. Crabtree
author_sort	Simon M. G. Braun
title	Rapid and reversible epigenome editing by endogenous chromatin regulators
title_short	Rapid and reversible epigenome editing by endogenous chromatin regulators
title_full	Rapid and reversible epigenome editing by endogenous chromatin regulators
title_fullStr	Rapid and reversible epigenome editing by endogenous chromatin regulators
title_full_unstemmed	Rapid and reversible epigenome editing by endogenous chromatin regulators
title_sort	rapid and reversible epigenome editing by endogenous chromatin regulators
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ceb7020dd5784ed49c21a33809ac7893
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Rapid and reversible epigenome editing by endogenous chromatin regulators

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