Effect of medication therapy combined with transcranial direct current stimulation on depression and response inhibition of patients with bipolar disorder type I: a clinical trial

Abstract Objective Bipolar Disorder (BD) is one of the most common mental disorders associated with depressive symptoms and impairment in executive functions such as response inhibition. This study aimed to investigate the effectiveness of medication therapy combined with Transcranial Direct Current...

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Autores principales:	Parnaz Mardani, Ahmad Zolghadriha, Mohsen Dadashi, Hossein Javdani, Seyedeh Elnaz Mousavi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Bipolar disorder Transcranial direct current stimulation Medication Depression Response inhibition Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/ceb76750ef47466cba467201a30baf85
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spelling	oai:doaj.org-article:ceb76750ef47466cba467201a30baf852021-11-21T12:05:17ZEffect of medication therapy combined with transcranial direct current stimulation on depression and response inhibition of patients with bipolar disorder type I: a clinical trial10.1186/s12888-021-03592-61471-244Xhttps://doaj.org/article/ceb76750ef47466cba467201a30baf852021-11-01T00:00:00Zhttps://doi.org/10.1186/s12888-021-03592-6https://doaj.org/toc/1471-244XAbstract Objective Bipolar Disorder (BD) is one of the most common mental disorders associated with depressive symptoms and impairment in executive functions such as response inhibition. This study aimed to investigate the effectiveness of medication therapy combined with Transcranial Direct Current Stimulation (tDCS) on depression and response inhibition of patients with BD. Method This is a double-blinded randomized clinical trial with pretest, posttest, and follow-up design. Participants were 30 patients with BD randomly assigned to two groups of Medication+tDCS (n = 15, receiving medications plus tDCS with 2 mA intensity over dorsolateral prefrontal cortex for 10 days, two sessions per day each for 20 min) and Medication (n = 15, receiving mood stabilizers including 2–5 tables of 300 mg (mg) lithium, 200 mg sodium valproate, and 200 mg carbamazepine two times per day). Pretest, posttest and 3-month follow-up assessments were the 21-item Hamilton Depression Rating Scale (HDRS) and a Go/No-Go test. Collected data were analyzed in SPSS v.20 software. Results The mean HDRS score in both groups was reduced after both interventional techniques, where the group received combined therapy showed more reduction (P < 0.01), although their effects were not maintained after 3 months. In examining response inhibition variable, only the combined therapy could reduce the commission error of patients under a go/no-go task (p < 0.05), but its effect was not maintained after 3 months. There was no significant difference in the group received medication therapy alone. Conclusion Medication in combination with tDCS can reduce the depressive symptoms and improve the response inhibition ability of people with BD. Trial registration This study was registred by Iranian Registry of Clinical Trials (Parallel, ID: IRCT20191229045931N1 , Registration date: 24/08/2020).Parnaz MardaniAhmad ZolghadrihaMohsen DadashiHossein JavdaniSeyedeh Elnaz MousaviBMCarticleBipolar disorderTranscranial direct current stimulationMedicationDepressionResponse inhibitionPsychiatryRC435-571ENBMC Psychiatry, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bipolar disorder Transcranial direct current stimulation Medication Depression Response inhibition Psychiatry RC435-571
spellingShingle	Bipolar disorder Transcranial direct current stimulation Medication Depression Response inhibition Psychiatry RC435-571 Parnaz Mardani Ahmad Zolghadriha Mohsen Dadashi Hossein Javdani Seyedeh Elnaz Mousavi Effect of medication therapy combined with transcranial direct current stimulation on depression and response inhibition of patients with bipolar disorder type I: a clinical trial
description	Abstract Objective Bipolar Disorder (BD) is one of the most common mental disorders associated with depressive symptoms and impairment in executive functions such as response inhibition. This study aimed to investigate the effectiveness of medication therapy combined with Transcranial Direct Current Stimulation (tDCS) on depression and response inhibition of patients with BD. Method This is a double-blinded randomized clinical trial with pretest, posttest, and follow-up design. Participants were 30 patients with BD randomly assigned to two groups of Medication+tDCS (n = 15, receiving medications plus tDCS with 2 mA intensity over dorsolateral prefrontal cortex for 10 days, two sessions per day each for 20 min) and Medication (n = 15, receiving mood stabilizers including 2–5 tables of 300 mg (mg) lithium, 200 mg sodium valproate, and 200 mg carbamazepine two times per day). Pretest, posttest and 3-month follow-up assessments were the 21-item Hamilton Depression Rating Scale (HDRS) and a Go/No-Go test. Collected data were analyzed in SPSS v.20 software. Results The mean HDRS score in both groups was reduced after both interventional techniques, where the group received combined therapy showed more reduction (P < 0.01), although their effects were not maintained after 3 months. In examining response inhibition variable, only the combined therapy could reduce the commission error of patients under a go/no-go task (p < 0.05), but its effect was not maintained after 3 months. There was no significant difference in the group received medication therapy alone. Conclusion Medication in combination with tDCS can reduce the depressive symptoms and improve the response inhibition ability of people with BD. Trial registration This study was registred by Iranian Registry of Clinical Trials (Parallel, ID: IRCT20191229045931N1 , Registration date: 24/08/2020).
format	article
author	Parnaz Mardani Ahmad Zolghadriha Mohsen Dadashi Hossein Javdani Seyedeh Elnaz Mousavi
author_facet	Parnaz Mardani Ahmad Zolghadriha Mohsen Dadashi Hossein Javdani Seyedeh Elnaz Mousavi
author_sort	Parnaz Mardani
title	Effect of medication therapy combined with transcranial direct current stimulation on depression and response inhibition of patients with bipolar disorder type I: a clinical trial
title_short	Effect of medication therapy combined with transcranial direct current stimulation on depression and response inhibition of patients with bipolar disorder type I: a clinical trial
title_full	Effect of medication therapy combined with transcranial direct current stimulation on depression and response inhibition of patients with bipolar disorder type I: a clinical trial
title_fullStr	Effect of medication therapy combined with transcranial direct current stimulation on depression and response inhibition of patients with bipolar disorder type I: a clinical trial
title_full_unstemmed	Effect of medication therapy combined with transcranial direct current stimulation on depression and response inhibition of patients with bipolar disorder type I: a clinical trial
title_sort	effect of medication therapy combined with transcranial direct current stimulation on depression and response inhibition of patients with bipolar disorder type i: a clinical trial
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ceb76750ef47466cba467201a30baf85
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Effect of medication therapy combined with transcranial direct current stimulation on depression and response inhibition of patients with bipolar disorder type I: a clinical trial

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