Increased Metabolic Burden Among Blacks: A Putative Mechanism for Disparate COVID-19 Outcomes
Girardin Jean-Louis,1 Arlener D Turner,1 Peng Jin,2 Mengling Liu,2 Carla Boutin-Foster,3 Samy I McFarlane,3 Azizi Seixas1 1Departments of Population Health, Psychiatry, and Biostatistics, New York University Langone Health, New York, NY, USA; 2Department of Biostatistics, New York University Langone...
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Dove Medical Press
2020
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oai:doaj.org-article:ceb7916db42a4974b1c4a3beaad43d812021-12-02T11:15:29ZIncreased Metabolic Burden Among Blacks: A Putative Mechanism for Disparate COVID-19 Outcomes1178-7007https://doaj.org/article/ceb7916db42a4974b1c4a3beaad43d812020-10-01T00:00:00Zhttps://www.dovepress.com/increased-metabolic-burden-among-blacks-a-putative-mechanism-fornbsp-d-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Girardin Jean-Louis,1 Arlener D Turner,1 Peng Jin,2 Mengling Liu,2 Carla Boutin-Foster,3 Samy I McFarlane,3 Azizi Seixas1 1Departments of Population Health, Psychiatry, and Biostatistics, New York University Langone Health, New York, NY, USA; 2Department of Biostatistics, New York University Langone Health, New York, NY, USA; 3Departments of Medicine and Endocrinology, SUNY Downstate Medical Center, New York, NY, USACorrespondence: Girardin Jean-LouisNYU Grossman School of Medicine, 180 Madison Avenue, 7th Floor, New York, NY 10016, USATel +1 646.501.3431Email Girardin.Jean-Louis@nyulangone.orgAbstract: Mounting evidence shows a disproportionate COVID-19 burden among Blacks. Early findings indicate pre-existing metabolic burden (eg, obesity, hypertension and diabetes) as key drivers of COVID-19 severity. Since Blacks exhibit higher prevalence of metabolic burden, we examined the influence of metabolic syndrome on disparate COVID-19 burden. We analyzed data from a NIH-funded study to characterize metabolic burden among Blacks in New York (Metabolic Syndrome Outcome Study). Patients (n=1035) were recruited from outpatient clinics, where clinical and self-report data were obtained. The vast majority of the sample was overweight/obese (90%); diagnosed with hypertension (93%); dyslipidemia (72%); diabetes (61%); and nearly half of them were at risk for sleep apnea (48%). Older Blacks (age≥ 65 years) were characterized by higher levels of metabolic burden and co-morbidities (eg, heart disease, cancer). In multivariate-adjusted regression analyses, age was a significant (p≤ .001) independent predictor of hypertension (OR=1.06; 95% CI: 1.04– 1.09), diabetes (OR=1.03; 95% CI: 1.02– 1.04), and dyslipidemia (OR=0.98; 95% CI: 0.97– 0.99), but not obesity. Our study demonstrates an overwhelmingly high prevalence of the metabolic risk factors related to COVID-19 among Blacks in New York, highlighting disparate metabolic burden among Blacks as a possible mechanism conferring the greater burden of COVID-19 infection and mortality represented in published data.Keywords: COVID-19 burden, blacks, metabolic syndrome, metabolic risk factors, disparitiesJean-Louis GTurner ADJin PLiu MBoutin-Foster CMcFarlane SISeixas ADove Medical Pressarticlecovid-19 burdenblacksmetabolic syndromemetabolic risk factorsdisparitiesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3471-3479 (2020) |
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covid-19 burden blacks metabolic syndrome metabolic risk factors disparities Specialties of internal medicine RC581-951 |
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covid-19 burden blacks metabolic syndrome metabolic risk factors disparities Specialties of internal medicine RC581-951 Jean-Louis G Turner AD Jin P Liu M Boutin-Foster C McFarlane SI Seixas A Increased Metabolic Burden Among Blacks: A Putative Mechanism for Disparate COVID-19 Outcomes |
| description |
Girardin Jean-Louis,1 Arlener D Turner,1 Peng Jin,2 Mengling Liu,2 Carla Boutin-Foster,3 Samy I McFarlane,3 Azizi Seixas1 1Departments of Population Health, Psychiatry, and Biostatistics, New York University Langone Health, New York, NY, USA; 2Department of Biostatistics, New York University Langone Health, New York, NY, USA; 3Departments of Medicine and Endocrinology, SUNY Downstate Medical Center, New York, NY, USACorrespondence: Girardin Jean-LouisNYU Grossman School of Medicine, 180 Madison Avenue, 7th Floor, New York, NY 10016, USATel +1 646.501.3431Email Girardin.Jean-Louis@nyulangone.orgAbstract: Mounting evidence shows a disproportionate COVID-19 burden among Blacks. Early findings indicate pre-existing metabolic burden (eg, obesity, hypertension and diabetes) as key drivers of COVID-19 severity. Since Blacks exhibit higher prevalence of metabolic burden, we examined the influence of metabolic syndrome on disparate COVID-19 burden. We analyzed data from a NIH-funded study to characterize metabolic burden among Blacks in New York (Metabolic Syndrome Outcome Study). Patients (n=1035) were recruited from outpatient clinics, where clinical and self-report data were obtained. The vast majority of the sample was overweight/obese (90%); diagnosed with hypertension (93%); dyslipidemia (72%); diabetes (61%); and nearly half of them were at risk for sleep apnea (48%). Older Blacks (age≥ 65 years) were characterized by higher levels of metabolic burden and co-morbidities (eg, heart disease, cancer). In multivariate-adjusted regression analyses, age was a significant (p≤ .001) independent predictor of hypertension (OR=1.06; 95% CI: 1.04– 1.09), diabetes (OR=1.03; 95% CI: 1.02– 1.04), and dyslipidemia (OR=0.98; 95% CI: 0.97– 0.99), but not obesity. Our study demonstrates an overwhelmingly high prevalence of the metabolic risk factors related to COVID-19 among Blacks in New York, highlighting disparate metabolic burden among Blacks as a possible mechanism conferring the greater burden of COVID-19 infection and mortality represented in published data.Keywords: COVID-19 burden, blacks, metabolic syndrome, metabolic risk factors, disparities |
| format |
article |
| author |
Jean-Louis G Turner AD Jin P Liu M Boutin-Foster C McFarlane SI Seixas A |
| author_facet |
Jean-Louis G Turner AD Jin P Liu M Boutin-Foster C McFarlane SI Seixas A |
| author_sort |
Jean-Louis G |
| title |
Increased Metabolic Burden Among Blacks: A Putative Mechanism for Disparate COVID-19 Outcomes |
| title_short |
Increased Metabolic Burden Among Blacks: A Putative Mechanism for Disparate COVID-19 Outcomes |
| title_full |
Increased Metabolic Burden Among Blacks: A Putative Mechanism for Disparate COVID-19 Outcomes |
| title_fullStr |
Increased Metabolic Burden Among Blacks: A Putative Mechanism for Disparate COVID-19 Outcomes |
| title_full_unstemmed |
Increased Metabolic Burden Among Blacks: A Putative Mechanism for Disparate COVID-19 Outcomes |
| title_sort |
increased metabolic burden among blacks: a putative mechanism for disparate covid-19 outcomes |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/ceb7916db42a4974b1c4a3beaad43d81 |
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