Identification of ZG16B as a prognostic biomarker in breast cancer

Zymogen granule protein 16B (ZG16B) has been identified in various cancers, while so far the association between ZG16B and breast cancer hasn’t been explored. Our aim is to confirm whether it can serve as a prognostic biomarker in breast cancer. In this study, Oncomine, Cancer Cell Line Encyclopedia...

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Autores principales:	Lu Haotian, Shi Chunying, Liu Xinyu, Liang Chen, Yang Chaochao, Wan Xueqi, Li Ling, Liu Ying
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	zg16b breast cancer database biomarker prognosis Medicine R
Acceso en línea:	https://doaj.org/article/ceba720823be4fbbb10686e4ea205a41
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id	oai:doaj.org-article:ceba720823be4fbbb10686e4ea205a41
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spelling	oai:doaj.org-article:ceba720823be4fbbb10686e4ea205a412021-12-05T14:10:53ZIdentification of ZG16B as a prognostic biomarker in breast cancer2391-546310.1515/med-2021-0004https://doaj.org/article/ceba720823be4fbbb10686e4ea205a412020-11-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0004https://doaj.org/toc/2391-5463Zymogen granule protein 16B (ZG16B) has been identified in various cancers, while so far the association between ZG16B and breast cancer hasn’t been explored. Our aim is to confirm whether it can serve as a prognostic biomarker in breast cancer. In this study, Oncomine, Cancer Cell Line Encyclopedia (CCLE), Ualcan, and STRING database analyses were conducted to detect the expression level of ZG16B in breast cancer with different types. Kaplan–Meier plotter was used to analyze the prognosis of patients with high or low expression of ZG16B. We found that ZG16B was significantly upregulated in breast cancer. Moreover, ZG16B was closely associated with foregone biomarkers and crucial factors in breast cancer. In the survival analysis, high expression of ZG16B represents a favorable prognosis in patients. Our work demonstrates the latent capacity of ZG16B to be a biomarker for prognosis of breast cancer.Lu HaotianShi ChunyingLiu XinyuLiang ChenYang ChaochaoWan XueqiLi LingLiu YingDe Gruyterarticlezg16bbreast cancerdatabasebiomarkerprognosisMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	zg16b breast cancer database biomarker prognosis Medicine R
spellingShingle	zg16b breast cancer database biomarker prognosis Medicine R Lu Haotian Shi Chunying Liu Xinyu Liang Chen Yang Chaochao Wan Xueqi Li Ling Liu Ying Identification of ZG16B as a prognostic biomarker in breast cancer
description	Zymogen granule protein 16B (ZG16B) has been identified in various cancers, while so far the association between ZG16B and breast cancer hasn’t been explored. Our aim is to confirm whether it can serve as a prognostic biomarker in breast cancer. In this study, Oncomine, Cancer Cell Line Encyclopedia (CCLE), Ualcan, and STRING database analyses were conducted to detect the expression level of ZG16B in breast cancer with different types. Kaplan–Meier plotter was used to analyze the prognosis of patients with high or low expression of ZG16B. We found that ZG16B was significantly upregulated in breast cancer. Moreover, ZG16B was closely associated with foregone biomarkers and crucial factors in breast cancer. In the survival analysis, high expression of ZG16B represents a favorable prognosis in patients. Our work demonstrates the latent capacity of ZG16B to be a biomarker for prognosis of breast cancer.
format	article
author	Lu Haotian Shi Chunying Liu Xinyu Liang Chen Yang Chaochao Wan Xueqi Li Ling Liu Ying
author_facet	Lu Haotian Shi Chunying Liu Xinyu Liang Chen Yang Chaochao Wan Xueqi Li Ling Liu Ying
author_sort	Lu Haotian
title	Identification of ZG16B as a prognostic biomarker in breast cancer
title_short	Identification of ZG16B as a prognostic biomarker in breast cancer
title_full	Identification of ZG16B as a prognostic biomarker in breast cancer
title_fullStr	Identification of ZG16B as a prognostic biomarker in breast cancer
title_full_unstemmed	Identification of ZG16B as a prognostic biomarker in breast cancer
title_sort	identification of zg16b as a prognostic biomarker in breast cancer
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/ceba720823be4fbbb10686e4ea205a41
work_keys_str_mv	AT luhaotian identificationofzg16basaprognosticbiomarkerinbreastcancer AT shichunying identificationofzg16basaprognosticbiomarkerinbreastcancer AT liuxinyu identificationofzg16basaprognosticbiomarkerinbreastcancer AT liangchen identificationofzg16basaprognosticbiomarkerinbreastcancer AT yangchaochao identificationofzg16basaprognosticbiomarkerinbreastcancer AT wanxueqi identificationofzg16basaprognosticbiomarkerinbreastcancer AT liling identificationofzg16basaprognosticbiomarkerinbreastcancer AT liuying identificationofzg16basaprognosticbiomarkerinbreastcancer
_version_	1718371628779307008

Identification of ZG16B as a prognostic biomarker in breast cancer

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