A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes

A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes

Reprogramming has been shown to involve EMT-MET; however, its role in cell differentiation is unclear. Here the authors show that duringin vitrodifferentiation of hepatocytes, Activin A-induced formation of definitive endoderm requires EMT mediated by TGFβ signalling, followed by a MET process.

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Autores principales: Qiuhong Li, Andrew P. Hutchins, Yong Chen, Shengbiao Li, Yongli Shan, Baojian Liao, Dejin Zheng, Xi Shi, Yinxiong Li, Wai-Yee Chan, Guangjin Pan, Shicheng Wei, Xiaodong Shu, Duanqing Pei
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/cec18cac0b1e41b2b6dcfc9392783321
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spelling oai:doaj.org-article:cec18cac0b1e41b2b6dcfc93927833212021-12-02T14:42:23ZA sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes10.1038/ncomms151662041-1723https://doaj.org/article/cec18cac0b1e41b2b6dcfc93927833212017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15166https://doaj.org/toc/2041-1723Reprogramming has been shown to involve EMT-MET; however, its role in cell differentiation is unclear. Here the authors show that duringin vitrodifferentiation of hepatocytes, Activin A-induced formation of definitive endoderm requires EMT mediated by TGFβ signalling, followed by a MET process.Qiuhong LiAndrew P. HutchinsYong ChenShengbiao LiYongli ShanBaojian LiaoDejin ZhengXi ShiYinxiong LiWai-Yee ChanGuangjin PanShicheng WeiXiaodong ShuDuanqing PeiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qiuhong Li
Andrew P. Hutchins
Yong Chen
Shengbiao Li
Yongli Shan
Baojian Liao
Dejin Zheng
Xi Shi
Yinxiong Li
Wai-Yee Chan
Guangjin Pan
Shicheng Wei
Xiaodong Shu
Duanqing Pei
A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes
description Reprogramming has been shown to involve EMT-MET; however, its role in cell differentiation is unclear. Here the authors show that duringin vitrodifferentiation of hepatocytes, Activin A-induced formation of definitive endoderm requires EMT mediated by TGFβ signalling, followed by a MET process.
format article
author Qiuhong Li
Andrew P. Hutchins
Yong Chen
Shengbiao Li
Yongli Shan
Baojian Liao
Dejin Zheng
Xi Shi
Yinxiong Li
Wai-Yee Chan
Guangjin Pan
Shicheng Wei
Xiaodong Shu
Duanqing Pei
author_facet Qiuhong Li
Andrew P. Hutchins
Yong Chen
Shengbiao Li
Yongli Shan
Baojian Liao
Dejin Zheng
Xi Shi
Yinxiong Li
Wai-Yee Chan
Guangjin Pan
Shicheng Wei
Xiaodong Shu
Duanqing Pei
author_sort Qiuhong Li
title A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes
title_short A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes
title_full A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes
title_fullStr A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes
title_full_unstemmed A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes
title_sort sequential emt-met mechanism drives the differentiation of human embryonic stem cells towards hepatocytes
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/cec18cac0b1e41b2b6dcfc9392783321
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