Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization

Tumor microenvironment varies between primary and metastatic sites. Here they report tumor-associated macrophages from metastatic sites to be predominantly M2 type, and secrete IL-35 to promote metastasis through activation of JAK2–STAT6–GATA3 signaling.

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Autores principales:	Chih-Chan Lee, Jiunn-Chang Lin, Wei-Lun Hwang, Ying-Ju Kuo, Hung-Kai Chen, Shyh-Kuan Tai, Chun-Chi Lin, Muh-Hwa Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cec4741886e6453981505003b003d69a
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spelling	oai:doaj.org-article:cec4741886e6453981505003b003d69a2021-12-02T15:33:45ZMacrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization10.1038/s41467-018-06268-02041-1723https://doaj.org/article/cec4741886e6453981505003b003d69a2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06268-0https://doaj.org/toc/2041-1723Tumor microenvironment varies between primary and metastatic sites. Here they report tumor-associated macrophages from metastatic sites to be predominantly M2 type, and secrete IL-35 to promote metastasis through activation of JAK2–STAT6–GATA3 signaling.Chih-Chan LeeJiunn-Chang LinWei-Lun HwangYing-Ju KuoHung-Kai ChenShyh-Kuan TaiChun-Chi LinMuh-Hwa YangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chih-Chan Lee Jiunn-Chang Lin Wei-Lun Hwang Ying-Ju Kuo Hung-Kai Chen Shyh-Kuan Tai Chun-Chi Lin Muh-Hwa Yang Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization
description	Tumor microenvironment varies between primary and metastatic sites. Here they report tumor-associated macrophages from metastatic sites to be predominantly M2 type, and secrete IL-35 to promote metastasis through activation of JAK2–STAT6–GATA3 signaling.
format	article
author	Chih-Chan Lee Jiunn-Chang Lin Wei-Lun Hwang Ying-Ju Kuo Hung-Kai Chen Shyh-Kuan Tai Chun-Chi Lin Muh-Hwa Yang
author_facet	Chih-Chan Lee Jiunn-Chang Lin Wei-Lun Hwang Ying-Ju Kuo Hung-Kai Chen Shyh-Kuan Tai Chun-Chi Lin Muh-Hwa Yang
author_sort	Chih-Chan Lee
title	Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization
title_short	Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization
title_full	Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization
title_fullStr	Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization
title_full_unstemmed	Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization
title_sort	macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cec4741886e6453981505003b003d69a
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Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization

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