Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization

Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization

Tumor microenvironment varies between primary and metastatic sites. Here they report tumor-associated macrophages from metastatic sites to be predominantly M2 type, and secrete IL-35 to promote metastasis through activation of JAK2–STAT6–GATA3 signaling.

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Detalles Bibliográficos
Autores principales: Chih-Chan Lee, Jiunn-Chang Lin, Wei-Lun Hwang, Ying-Ju Kuo, Hung-Kai Chen, Shyh-Kuan Tai, Chun-Chi Lin, Muh-Hwa Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/cec4741886e6453981505003b003d69a
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