The risk of developing a meningioma during and after pregnancy

Abstract Pregnancy has been associated with diagnosis or growth of meningiomas in several case reports, which has led to the hypothesis that pregnancy may be a risk factor for meningiomas. The aim of this study was to test this hypothesis in a large population-based cohort study. Women born in Swede...

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Autores principales:	Jenny Pettersson-Segerlind, Tiit Mathiesen, Adrian Elmi-Terander, Erik Edström, Mats Talbäck, Maria Feychting, Giorgio Tettamanti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cec526ba91bf4ce9b0d692b426e2edcb
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spelling	oai:doaj.org-article:cec526ba91bf4ce9b0d692b426e2edcb2021-12-02T13:41:22ZThe risk of developing a meningioma during and after pregnancy10.1038/s41598-021-88742-22045-2322https://doaj.org/article/cec526ba91bf4ce9b0d692b426e2edcb2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88742-2https://doaj.org/toc/2045-2322Abstract Pregnancy has been associated with diagnosis or growth of meningiomas in several case reports, which has led to the hypothesis that pregnancy may be a risk factor for meningiomas. The aim of this study was to test this hypothesis in a large population-based cohort study. Women born in Sweden 1958–2000 (N = 2,204,126) were identified and matched with the Medical Birth Register and the Cancer Register. The expected number of meningioma cases and risk ratios were calculated for parous and nulliparous women and compared to the observed number of cases. Compared to parous women, meningiomas were more common among nulliparous (SIR = 1.73; 95% CI 1.52–1.95). The number of meningioma cases detected during pregnancy was lower than the expected (SIR = 0.40; 95% CI 0.20–0.72). Moreover, no increased risk was found in the first-year post-partum (SIR = 1.04; 95% CI 0.74–1.41). Contrary to our hypothesis, there was no increased risk for diagnosing a meningioma during pregnancy or 1-year post-partum. A lower detection rate during pregnancy, may reflect under-utilization of diagnostic procedures, but the actual number of meningiomas was homogenously lower among parous than nulliparous women throughout the study period, indicating that pregnancy is not a risk factor for meningioma.Jenny Pettersson-SegerlindTiit MathiesenAdrian Elmi-TeranderErik EdströmMats TalbäckMaria FeychtingGiorgio TettamantiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jenny Pettersson-Segerlind Tiit Mathiesen Adrian Elmi-Terander Erik Edström Mats Talbäck Maria Feychting Giorgio Tettamanti The risk of developing a meningioma during and after pregnancy
description	Abstract Pregnancy has been associated with diagnosis or growth of meningiomas in several case reports, which has led to the hypothesis that pregnancy may be a risk factor for meningiomas. The aim of this study was to test this hypothesis in a large population-based cohort study. Women born in Sweden 1958–2000 (N = 2,204,126) were identified and matched with the Medical Birth Register and the Cancer Register. The expected number of meningioma cases and risk ratios were calculated for parous and nulliparous women and compared to the observed number of cases. Compared to parous women, meningiomas were more common among nulliparous (SIR = 1.73; 95% CI 1.52–1.95). The number of meningioma cases detected during pregnancy was lower than the expected (SIR = 0.40; 95% CI 0.20–0.72). Moreover, no increased risk was found in the first-year post-partum (SIR = 1.04; 95% CI 0.74–1.41). Contrary to our hypothesis, there was no increased risk for diagnosing a meningioma during pregnancy or 1-year post-partum. A lower detection rate during pregnancy, may reflect under-utilization of diagnostic procedures, but the actual number of meningiomas was homogenously lower among parous than nulliparous women throughout the study period, indicating that pregnancy is not a risk factor for meningioma.
format	article
author	Jenny Pettersson-Segerlind Tiit Mathiesen Adrian Elmi-Terander Erik Edström Mats Talbäck Maria Feychting Giorgio Tettamanti
author_facet	Jenny Pettersson-Segerlind Tiit Mathiesen Adrian Elmi-Terander Erik Edström Mats Talbäck Maria Feychting Giorgio Tettamanti
author_sort	Jenny Pettersson-Segerlind
title	The risk of developing a meningioma during and after pregnancy
title_short	The risk of developing a meningioma during and after pregnancy
title_full	The risk of developing a meningioma during and after pregnancy
title_fullStr	The risk of developing a meningioma during and after pregnancy
title_full_unstemmed	The risk of developing a meningioma during and after pregnancy
title_sort	risk of developing a meningioma during and after pregnancy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cec526ba91bf4ce9b0d692b426e2edcb
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The risk of developing a meningioma during and after pregnancy

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