Ingestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress

Abstract Social stress exacerbates anxious and depressive behaviors in humans. Similarly, anxiety- and depressive-like behaviors are triggered by social stress in a variety of non-human animals. Here, we tested whether oral administration of the putative anxiolytic probiotic strains Lactobacillus he...

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Autores principales:	Katherine A. Partrick, Anna M. Rosenhauer, Jérémie Auger, Amanda R. Arnold, Nicole M. Ronczkowski, Lanaya M. Jackson, Magen N. Lord, Sara M. Abdulla, Benoit Chassaing, Kim L. Huhman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cec7c778803c4d20b6ee8504d3fc16a7
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spelling	oai:doaj.org-article:cec7c778803c4d20b6ee8504d3fc16a72021-12-02T13:30:22ZIngestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress10.1038/s41598-021-83284-z2045-2322https://doaj.org/article/cec7c778803c4d20b6ee8504d3fc16a72021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83284-zhttps://doaj.org/toc/2045-2322Abstract Social stress exacerbates anxious and depressive behaviors in humans. Similarly, anxiety- and depressive-like behaviors are triggered by social stress in a variety of non-human animals. Here, we tested whether oral administration of the putative anxiolytic probiotic strains Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces the striking increase in anxiety-like behavior and changes in gut microbiota observed following social defeat stress in Syrian hamsters. We administered the probiotic at two different doses for 21 days, and 16S rRNA gene amplicon sequencing revealed a shift in microbial structure following probiotic administration at both doses, independently of stress. Probiotic administration at either dose increased anti-inflammatory cytokines IL-4, IL-5, and IL-10 compared to placebo. Surprisingly, probiotic administration at the low dose, equivalent to the one used in humans, significantly increased social avoidance and decreased social interaction. This behavioral change was associated with a reduction in microbial richness in this group. Together, these results demonstrate that probiotic administration alters gut microbial composition and may promote an anti-inflammatory profile but that these changes may not promote reductions in behavioral responses to social stress.Katherine A. PartrickAnna M. RosenhauerJérémie AugerAmanda R. ArnoldNicole M. RonczkowskiLanaya M. JacksonMagen N. LordSara M. AbdullaBenoit ChassaingKim L. HuhmanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katherine A. Partrick Anna M. Rosenhauer Jérémie Auger Amanda R. Arnold Nicole M. Ronczkowski Lanaya M. Jackson Magen N. Lord Sara M. Abdulla Benoit Chassaing Kim L. Huhman Ingestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress
description	Abstract Social stress exacerbates anxious and depressive behaviors in humans. Similarly, anxiety- and depressive-like behaviors are triggered by social stress in a variety of non-human animals. Here, we tested whether oral administration of the putative anxiolytic probiotic strains Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces the striking increase in anxiety-like behavior and changes in gut microbiota observed following social defeat stress in Syrian hamsters. We administered the probiotic at two different doses for 21 days, and 16S rRNA gene amplicon sequencing revealed a shift in microbial structure following probiotic administration at both doses, independently of stress. Probiotic administration at either dose increased anti-inflammatory cytokines IL-4, IL-5, and IL-10 compared to placebo. Surprisingly, probiotic administration at the low dose, equivalent to the one used in humans, significantly increased social avoidance and decreased social interaction. This behavioral change was associated with a reduction in microbial richness in this group. Together, these results demonstrate that probiotic administration alters gut microbial composition and may promote an anti-inflammatory profile but that these changes may not promote reductions in behavioral responses to social stress.
format	article
author	Katherine A. Partrick Anna M. Rosenhauer Jérémie Auger Amanda R. Arnold Nicole M. Ronczkowski Lanaya M. Jackson Magen N. Lord Sara M. Abdulla Benoit Chassaing Kim L. Huhman
author_facet	Katherine A. Partrick Anna M. Rosenhauer Jérémie Auger Amanda R. Arnold Nicole M. Ronczkowski Lanaya M. Jackson Magen N. Lord Sara M. Abdulla Benoit Chassaing Kim L. Huhman
author_sort	Katherine A. Partrick
title	Ingestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress
title_short	Ingestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress
title_full	Ingestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress
title_fullStr	Ingestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress
title_full_unstemmed	Ingestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress
title_sort	ingestion of probiotic (lactobacillus helveticus and bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cec7c778803c4d20b6ee8504d3fc16a7
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Ingestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress

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