Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions

Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions

Genetic sensors can be created by mix and matching DNA-binding modules with ligand-binding modules. Here the authors use a computational model to overcome module incompatibilities and restore function by rescuing key interactions.

Guardado en:
Detalles Bibliográficos
Autores principales: Xian-Li Jiang, Rey P. Dimas, Clement T. Y. Chan, Faruck Morcos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/cec9375bf6eb42b9bab94705b00a26b9
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:cec9375bf6eb42b9bab94705b00a26b9
record_format dspace
spelling oai:doaj.org-article:cec9375bf6eb42b9bab94705b00a26b92021-12-02T15:15:14ZCoevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions10.1038/s41467-021-25851-62041-1723https://doaj.org/article/cec9375bf6eb42b9bab94705b00a26b92021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25851-6https://doaj.org/toc/2041-1723Genetic sensors can be created by mix and matching DNA-binding modules with ligand-binding modules. Here the authors use a computational model to overcome module incompatibilities and restore function by rescuing key interactions.Xian-Li JiangRey P. DimasClement T. Y. ChanFaruck MorcosNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xian-Li Jiang
Rey P. Dimas
Clement T. Y. Chan
Faruck Morcos
Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions
description Genetic sensors can be created by mix and matching DNA-binding modules with ligand-binding modules. Here the authors use a computational model to overcome module incompatibilities and restore function by rescuing key interactions.
format article
author Xian-Li Jiang
Rey P. Dimas
Clement T. Y. Chan
Faruck Morcos
author_facet Xian-Li Jiang
Rey P. Dimas
Clement T. Y. Chan
Faruck Morcos
author_sort Xian-Li Jiang
title Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions
title_short Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions
title_full Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions
title_fullStr Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions
title_full_unstemmed Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions
title_sort coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/cec9375bf6eb42b9bab94705b00a26b9
work_keys_str_mv AT xianlijiang coevolutionarymethodsenablerobustdesignofmodularrepressorsbyreestablishingintraproteininteractions
AT reypdimas coevolutionarymethodsenablerobustdesignofmodularrepressorsbyreestablishingintraproteininteractions
AT clementtychan coevolutionarymethodsenablerobustdesignofmodularrepressorsbyreestablishingintraproteininteractions
AT faruckmorcos coevolutionarymethodsenablerobustdesignofmodularrepressorsbyreestablishingintraproteininteractions
_version_ 1718387537162010624

Ejemplares similares