Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions
Genetic sensors can be created by mix and matching DNA-binding modules with ligand-binding modules. Here the authors use a computational model to overcome module incompatibilities and restore function by rescuing key interactions.
Guardado en:
Autores principales: | Xian-Li Jiang, Rey P. Dimas, Clement T. Y. Chan, Faruck Morcos |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/cec9375bf6eb42b9bab94705b00a26b9 |
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