Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions

Genetic sensors can be created by mix and matching DNA-binding modules with ligand-binding modules. Here the authors use a computational model to overcome module incompatibilities and restore function by rescuing key interactions.

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Autores principales: Xian-Li Jiang, Rey P. Dimas, Clement T. Y. Chan, Faruck Morcos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/cec9375bf6eb42b9bab94705b00a26b9
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