Association Analyses of SNAP25, HNMT, FCHSD1, and DBH Single-Nucleotide Polymorphisms with Parkinson’s Disease in a Northern Chinese Population

Cuiyun Dai, Yichi Zhang, Xiaoni Zhan, Meihui Tian, Hao Pang Department of Forensic Genetics and Biology, School of Forensic Medicine, China Medical University, Shenyang, 110122, People’s Republic of ChinaCorrespondence: Hao Pang Tel +86-24-31939435Email hpang@cmu.edu.cnPurpose: Sequencing...

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Autores principales: Dai C, Zhang Y, Zhan X, Tian M, Pang H
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Publicado: Dove Medical Press 2021
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spelling oai:doaj.org-article:cece2e5991ef46f49a9552725cb57dd42021-12-02T15:55:04ZAssociation Analyses of SNAP25, HNMT, FCHSD1, and DBH Single-Nucleotide Polymorphisms with Parkinson’s Disease in a Northern Chinese Population1178-2021https://doaj.org/article/cece2e5991ef46f49a9552725cb57dd42021-05-01T00:00:00Zhttps://www.dovepress.com/association-analyses-of-snap25-hnmt-fchsd1-and-dbh-single-nucleotide-p-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Cuiyun Dai, Yichi Zhang, Xiaoni Zhan, Meihui Tian, Hao Pang Department of Forensic Genetics and Biology, School of Forensic Medicine, China Medical University, Shenyang, 110122, People’s Republic of ChinaCorrespondence: Hao Pang Tel +86-24-31939435Email hpang@cmu.edu.cnPurpose: Sequencing potentially causal and susceptible genes and genome-wide association studies in samples from Parkinson’s disease (PD) patients has revealed several related loci. The genes for synaptosome-associated protein of 25 kDa (SNAP25), histamine-N-methyltransferase (HNMT), FCH and double SH3 domains 1 (FCHSD1) and dopamine β-hydroxylase (DBH) are candidate loci and have not been studied in a northern Chinese population. We explored the genetic distribution of four single-nucleotide polymorphisms (rs3746544, rs11558538, rs456998, rs129882) located on SNAP25, HNMT, FCHSD1 and DBH, respectively.Patients and Methods: A total of 330 patients with sporadic PD and 332 healthy controls (HCs) were recruited from a northern Chinese population. Polymerase chain reaction restriction fragment length polymorphism was used to genotype these four SNPs.Results: After statistical analyses and correction of the genotyping results, the mutant-allele T in rs456998 of FCHSD1 was found to be significantly related to reducing the PD risk (P = 0.029, OR = 0.754, 95% CI = 0.586– 0.971, power = 0.591). However, rs3746544, rs11558538, and rs129882 did not show an association with PD.Conclusion: FCHSD1 rs456998 may have a protective role in PD in a northern Chinese population, but more studies are needed to support this suggestion.Keywords: Parkinson’s disease, single nucleotide polymorphism, SNAP25, HNMT, FCHSD1, DBH, association studyDai CZhang YZhan XTian MPang HDove Medical Pressarticleparkinson’s diseasesingle nucleotide polymorphismsnap25hnmtfchsd1dbhassociation studyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 1689-1695 (2021)
institution DOAJ
collection DOAJ
language EN
topic parkinson’s disease
single nucleotide polymorphism
snap25
hnmt
fchsd1
dbh
association study
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle parkinson’s disease
single nucleotide polymorphism
snap25
hnmt
fchsd1
dbh
association study
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Dai C
Zhang Y
Zhan X
Tian M
Pang H
Association Analyses of SNAP25, HNMT, FCHSD1, and DBH Single-Nucleotide Polymorphisms with Parkinson’s Disease in a Northern Chinese Population
description Cuiyun Dai, Yichi Zhang, Xiaoni Zhan, Meihui Tian, Hao Pang Department of Forensic Genetics and Biology, School of Forensic Medicine, China Medical University, Shenyang, 110122, People’s Republic of ChinaCorrespondence: Hao Pang Tel +86-24-31939435Email hpang@cmu.edu.cnPurpose: Sequencing potentially causal and susceptible genes and genome-wide association studies in samples from Parkinson’s disease (PD) patients has revealed several related loci. The genes for synaptosome-associated protein of 25 kDa (SNAP25), histamine-N-methyltransferase (HNMT), FCH and double SH3 domains 1 (FCHSD1) and dopamine β-hydroxylase (DBH) are candidate loci and have not been studied in a northern Chinese population. We explored the genetic distribution of four single-nucleotide polymorphisms (rs3746544, rs11558538, rs456998, rs129882) located on SNAP25, HNMT, FCHSD1 and DBH, respectively.Patients and Methods: A total of 330 patients with sporadic PD and 332 healthy controls (HCs) were recruited from a northern Chinese population. Polymerase chain reaction restriction fragment length polymorphism was used to genotype these four SNPs.Results: After statistical analyses and correction of the genotyping results, the mutant-allele T in rs456998 of FCHSD1 was found to be significantly related to reducing the PD risk (P = 0.029, OR = 0.754, 95% CI = 0.586– 0.971, power = 0.591). However, rs3746544, rs11558538, and rs129882 did not show an association with PD.Conclusion: FCHSD1 rs456998 may have a protective role in PD in a northern Chinese population, but more studies are needed to support this suggestion.Keywords: Parkinson’s disease, single nucleotide polymorphism, SNAP25, HNMT, FCHSD1, DBH, association study
format article
author Dai C
Zhang Y
Zhan X
Tian M
Pang H
author_facet Dai C
Zhang Y
Zhan X
Tian M
Pang H
author_sort Dai C
title Association Analyses of SNAP25, HNMT, FCHSD1, and DBH Single-Nucleotide Polymorphisms with Parkinson’s Disease in a Northern Chinese Population
title_short Association Analyses of SNAP25, HNMT, FCHSD1, and DBH Single-Nucleotide Polymorphisms with Parkinson’s Disease in a Northern Chinese Population
title_full Association Analyses of SNAP25, HNMT, FCHSD1, and DBH Single-Nucleotide Polymorphisms with Parkinson’s Disease in a Northern Chinese Population
title_fullStr Association Analyses of SNAP25, HNMT, FCHSD1, and DBH Single-Nucleotide Polymorphisms with Parkinson’s Disease in a Northern Chinese Population
title_full_unstemmed Association Analyses of SNAP25, HNMT, FCHSD1, and DBH Single-Nucleotide Polymorphisms with Parkinson’s Disease in a Northern Chinese Population
title_sort association analyses of snap25, hnmt, fchsd1, and dbh single-nucleotide polymorphisms with parkinson’s disease in a northern chinese population
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/cece2e5991ef46f49a9552725cb57dd4
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