ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

Ca2+ release-activated Ca2+(CRAC) channels are essential for protective immunity, but the immunological functions of the three ORAI homologues that form CRAC channels are unclear. Here the authors show that ORAI1 and ORAI2 form heteromeric CRAC channels, which fine-tune T cell activation and immune...

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Autores principales:	Martin Vaeth, Jun Yang, Megumi Yamashita, Isabelle Zee, Miriam Eckstein, Camille Knosp, Ulrike Kaufmann, Peter Karoly Jani, Rodrigo S. Lacruz, Veit Flockerzi, Imre Kacskovics, Murali Prakriya, Stefan Feske
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cecf348141a04e5d97c610a4720fbbd4
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spelling	oai:doaj.org-article:cecf348141a04e5d97c610a4720fbbd42021-12-02T14:42:23ZORAI2 modulates store-operated calcium entry and T cell-mediated immunity10.1038/ncomms147142041-1723https://doaj.org/article/cecf348141a04e5d97c610a4720fbbd42017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14714https://doaj.org/toc/2041-1723Ca2+ release-activated Ca2+(CRAC) channels are essential for protective immunity, but the immunological functions of the three ORAI homologues that form CRAC channels are unclear. Here the authors show that ORAI1 and ORAI2 form heteromeric CRAC channels, which fine-tune T cell activation and immune responses.Martin VaethJun YangMegumi YamashitaIsabelle ZeeMiriam EcksteinCamille KnospUlrike KaufmannPeter Karoly JaniRodrigo S. LacruzVeit FlockerziImre KacskovicsMurali PrakriyaStefan FeskeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Vaeth Jun Yang Megumi Yamashita Isabelle Zee Miriam Eckstein Camille Knosp Ulrike Kaufmann Peter Karoly Jani Rodrigo S. Lacruz Veit Flockerzi Imre Kacskovics Murali Prakriya Stefan Feske ORAI2 modulates store-operated calcium entry and T cell-mediated immunity
description	Ca2+ release-activated Ca2+(CRAC) channels are essential for protective immunity, but the immunological functions of the three ORAI homologues that form CRAC channels are unclear. Here the authors show that ORAI1 and ORAI2 form heteromeric CRAC channels, which fine-tune T cell activation and immune responses.
format	article
author	Martin Vaeth Jun Yang Megumi Yamashita Isabelle Zee Miriam Eckstein Camille Knosp Ulrike Kaufmann Peter Karoly Jani Rodrigo S. Lacruz Veit Flockerzi Imre Kacskovics Murali Prakriya Stefan Feske
author_facet	Martin Vaeth Jun Yang Megumi Yamashita Isabelle Zee Miriam Eckstein Camille Knosp Ulrike Kaufmann Peter Karoly Jani Rodrigo S. Lacruz Veit Flockerzi Imre Kacskovics Murali Prakriya Stefan Feske
author_sort	Martin Vaeth
title	ORAI2 modulates store-operated calcium entry and T cell-mediated immunity
title_short	ORAI2 modulates store-operated calcium entry and T cell-mediated immunity
title_full	ORAI2 modulates store-operated calcium entry and T cell-mediated immunity
title_fullStr	ORAI2 modulates store-operated calcium entry and T cell-mediated immunity
title_full_unstemmed	ORAI2 modulates store-operated calcium entry and T cell-mediated immunity
title_sort	orai2 modulates store-operated calcium entry and t cell-mediated immunity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cecf348141a04e5d97c610a4720fbbd4
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ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

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