Comparative study of cefixime and tetracycline as an evaluation policy driven by the antibiotic resistance crisis in Indonesia

Abstract Antibiotic resistance is a serious threat that occurs globally in the health sector due to increased consumption of inappropriate antibiotics. Guidelines for prescribing antibiotics for ARTIs have been issued in general practice to promote rational antibiotic prescribing. This study was con...

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Autores principales:	Danni Ramdhani, Sri Agung Fitri Kusuma, Dede Sediana, A. P. Hilarius Bima, Ika Khumairoh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ced09fb9c48e423dac8661652aa0c09f
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spelling	oai:doaj.org-article:ced09fb9c48e423dac8661652aa0c09f2021-12-02T15:15:44ZComparative study of cefixime and tetracycline as an evaluation policy driven by the antibiotic resistance crisis in Indonesia10.1038/s41598-021-98129-y2045-2322https://doaj.org/article/ced09fb9c48e423dac8661652aa0c09f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98129-yhttps://doaj.org/toc/2045-2322Abstract Antibiotic resistance is a serious threat that occurs globally in the health sector due to increased consumption of inappropriate antibiotics. Guidelines for prescribing antibiotics for ARTIs have been issued in general practice to promote rational antibiotic prescribing. This study was conducted to compare the effectiveness of cefixime and tetracycline as a solution to improve monitoring of appropriate antibiotic use in the treatment of ARTIs. All stock isolates were rejuvenated first, and cultured on standard media and Kirby–Bauer disc diffusion method was used for susceptibility testing in accordance with the Clinical and Laboratory Standard Institute’s (CLSI) recommendations. Identification of bacteria from a single isolate was carried out to determine which bacteria were resistant to cefixime and tetracycline. A total of 466 single isolates of bacteria were analyzed, which showed a percentage of resistance to cefixime 38.0%, and tetracycline 92.86%. Bacterial isolates were resistant to cefixime and tetracycilne was a genus of Haemophilus, Streptococcus, Corynebacterium, Staphylococcus, and bordetella. Cefixime compared to tetracycline was proven to be superior in terms of the effectiveness of ARIs treatment.Danni RamdhaniSri Agung Fitri KusumaDede SedianaA. P. Hilarius BimaIka KhumairohNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Danni Ramdhani Sri Agung Fitri Kusuma Dede Sediana A. P. Hilarius Bima Ika Khumairoh Comparative study of cefixime and tetracycline as an evaluation policy driven by the antibiotic resistance crisis in Indonesia
description	Abstract Antibiotic resistance is a serious threat that occurs globally in the health sector due to increased consumption of inappropriate antibiotics. Guidelines for prescribing antibiotics for ARTIs have been issued in general practice to promote rational antibiotic prescribing. This study was conducted to compare the effectiveness of cefixime and tetracycline as a solution to improve monitoring of appropriate antibiotic use in the treatment of ARTIs. All stock isolates were rejuvenated first, and cultured on standard media and Kirby–Bauer disc diffusion method was used for susceptibility testing in accordance with the Clinical and Laboratory Standard Institute’s (CLSI) recommendations. Identification of bacteria from a single isolate was carried out to determine which bacteria were resistant to cefixime and tetracycline. A total of 466 single isolates of bacteria were analyzed, which showed a percentage of resistance to cefixime 38.0%, and tetracycline 92.86%. Bacterial isolates were resistant to cefixime and tetracycilne was a genus of Haemophilus, Streptococcus, Corynebacterium, Staphylococcus, and bordetella. Cefixime compared to tetracycline was proven to be superior in terms of the effectiveness of ARIs treatment.
format	article
author	Danni Ramdhani Sri Agung Fitri Kusuma Dede Sediana A. P. Hilarius Bima Ika Khumairoh
author_facet	Danni Ramdhani Sri Agung Fitri Kusuma Dede Sediana A. P. Hilarius Bima Ika Khumairoh
author_sort	Danni Ramdhani
title	Comparative study of cefixime and tetracycline as an evaluation policy driven by the antibiotic resistance crisis in Indonesia
title_short	Comparative study of cefixime and tetracycline as an evaluation policy driven by the antibiotic resistance crisis in Indonesia
title_full	Comparative study of cefixime and tetracycline as an evaluation policy driven by the antibiotic resistance crisis in Indonesia
title_fullStr	Comparative study of cefixime and tetracycline as an evaluation policy driven by the antibiotic resistance crisis in Indonesia
title_full_unstemmed	Comparative study of cefixime and tetracycline as an evaluation policy driven by the antibiotic resistance crisis in Indonesia
title_sort	comparative study of cefixime and tetracycline as an evaluation policy driven by the antibiotic resistance crisis in indonesia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ced09fb9c48e423dac8661652aa0c09f
work_keys_str_mv	AT danniramdhani comparativestudyofcefiximeandtetracyclineasanevaluationpolicydrivenbytheantibioticresistancecrisisinindonesia AT sriagungfitrikusuma comparativestudyofcefiximeandtetracyclineasanevaluationpolicydrivenbytheantibioticresistancecrisisinindonesia AT dedesediana comparativestudyofcefiximeandtetracyclineasanevaluationpolicydrivenbytheantibioticresistancecrisisinindonesia AT aphilariusbima comparativestudyofcefiximeandtetracyclineasanevaluationpolicydrivenbytheantibioticresistancecrisisinindonesia AT ikakhumairoh comparativestudyofcefiximeandtetracyclineasanevaluationpolicydrivenbytheantibioticresistancecrisisinindonesia
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Comparative study of cefixime and tetracycline as an evaluation policy driven by the antibiotic resistance crisis in Indonesia

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