Corneal inflammatory cell infiltration predicts disease activity in chronic inflammatory demyelinating polyneuropathy

Abstract The assessment of disease activity is fundamental in the management of chronic inflammatory demyelinating polyneuropathy (CIDP). Previous studies with small patient numbers found an increase of corneal immune cell infiltrates as a potential marker of inflammation in patients with CIDP. Howe...

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Autores principales:	Jeremias Motte, Thomas Grüter, Anna Lena Fisse, Yesim Bulut, Zornitsa Stykova, Tineke Greiner, Elena Enax-Krumova, Min-Suk Yoon, Ralf Gold, Martin Tegenthoff, Dietrich Sturm, Kalliopi Pitarokoili
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ced1f50804d04df08d39bc71dc83127c
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spelling	oai:doaj.org-article:ced1f50804d04df08d39bc71dc83127c2021-12-02T16:23:43ZCorneal inflammatory cell infiltration predicts disease activity in chronic inflammatory demyelinating polyneuropathy10.1038/s41598-021-94605-72045-2322https://doaj.org/article/ced1f50804d04df08d39bc71dc83127c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94605-7https://doaj.org/toc/2045-2322Abstract The assessment of disease activity is fundamental in the management of chronic inflammatory demyelinating polyneuropathy (CIDP). Previous studies with small patient numbers found an increase of corneal immune cell infiltrates as a potential marker of inflammation in patients with CIDP. However, its clinical relevance remained unclear. The present study aimed to determine whether the amount of corneal inflammatory cells (CIC) measured by corneal confocal microscopy (CCM) detects disease activity in CIDP. CIC were measured in 142 CCM-investigations of 97 CIDP-patients. Data on clinical disease activity, disability (INCAT-ODSS) and need for therapy escalation at the timepoint of CCM, 3 and 6 months later were analyzed depending CIC-count. Pathological spontaneous activity during electromyography was examined as another possible biomarker for disease activity in comparison to CIC-count. An increased CIC-count at baseline was found in patients with clinical disease activity and disability progression in the following 3–6 months. An increase to more than 25 CIC/mm2 had a sensitivity of 0.73 and a specificity of 0.71 to detect clinical disease activity and a sensitivity of 0.77 and a specificity of 0.64 to detect disability progression (increasing INCAT-ODSS) in the following 6 months. An increase to more than 50 CIC/mm2 had a sensitivity of about 0.51 and a specificity of 0.91 to detect clinical disease activity and a sensitivity of 0.53 and a specificity of 0.80 to detect disability progression. CIC count is a non-invasive biomarker for the detection of disease activity in the following 6 months in CIDP.Jeremias MotteThomas GrüterAnna Lena FisseYesim BulutZornitsa StykovaTineke GreinerElena Enax-KrumovaMin-Suk YoonRalf GoldMartin TegenthoffDietrich SturmKalliopi PitarokoiliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeremias Motte Thomas Grüter Anna Lena Fisse Yesim Bulut Zornitsa Stykova Tineke Greiner Elena Enax-Krumova Min-Suk Yoon Ralf Gold Martin Tegenthoff Dietrich Sturm Kalliopi Pitarokoili Corneal inflammatory cell infiltration predicts disease activity in chronic inflammatory demyelinating polyneuropathy
description	Abstract The assessment of disease activity is fundamental in the management of chronic inflammatory demyelinating polyneuropathy (CIDP). Previous studies with small patient numbers found an increase of corneal immune cell infiltrates as a potential marker of inflammation in patients with CIDP. However, its clinical relevance remained unclear. The present study aimed to determine whether the amount of corneal inflammatory cells (CIC) measured by corneal confocal microscopy (CCM) detects disease activity in CIDP. CIC were measured in 142 CCM-investigations of 97 CIDP-patients. Data on clinical disease activity, disability (INCAT-ODSS) and need for therapy escalation at the timepoint of CCM, 3 and 6 months later were analyzed depending CIC-count. Pathological spontaneous activity during electromyography was examined as another possible biomarker for disease activity in comparison to CIC-count. An increased CIC-count at baseline was found in patients with clinical disease activity and disability progression in the following 3–6 months. An increase to more than 25 CIC/mm2 had a sensitivity of 0.73 and a specificity of 0.71 to detect clinical disease activity and a sensitivity of 0.77 and a specificity of 0.64 to detect disability progression (increasing INCAT-ODSS) in the following 6 months. An increase to more than 50 CIC/mm2 had a sensitivity of about 0.51 and a specificity of 0.91 to detect clinical disease activity and a sensitivity of 0.53 and a specificity of 0.80 to detect disability progression. CIC count is a non-invasive biomarker for the detection of disease activity in the following 6 months in CIDP.
format	article
author	Jeremias Motte Thomas Grüter Anna Lena Fisse Yesim Bulut Zornitsa Stykova Tineke Greiner Elena Enax-Krumova Min-Suk Yoon Ralf Gold Martin Tegenthoff Dietrich Sturm Kalliopi Pitarokoili
author_facet	Jeremias Motte Thomas Grüter Anna Lena Fisse Yesim Bulut Zornitsa Stykova Tineke Greiner Elena Enax-Krumova Min-Suk Yoon Ralf Gold Martin Tegenthoff Dietrich Sturm Kalliopi Pitarokoili
author_sort	Jeremias Motte
title	Corneal inflammatory cell infiltration predicts disease activity in chronic inflammatory demyelinating polyneuropathy
title_short	Corneal inflammatory cell infiltration predicts disease activity in chronic inflammatory demyelinating polyneuropathy
title_full	Corneal inflammatory cell infiltration predicts disease activity in chronic inflammatory demyelinating polyneuropathy
title_fullStr	Corneal inflammatory cell infiltration predicts disease activity in chronic inflammatory demyelinating polyneuropathy
title_full_unstemmed	Corneal inflammatory cell infiltration predicts disease activity in chronic inflammatory demyelinating polyneuropathy
title_sort	corneal inflammatory cell infiltration predicts disease activity in chronic inflammatory demyelinating polyneuropathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ced1f50804d04df08d39bc71dc83127c
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Corneal inflammatory cell infiltration predicts disease activity in chronic inflammatory demyelinating polyneuropathy

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