Consideration of Epstein-Barr Virus-Encoded Noncoding RNAs EBER1 and EBER2 as a Functional Backup of Viral Oncoprotein Latent Membrane Protein 1
ABSTRACT The Epstein-Barr virus (EBV)-encoded noncoding RNAs EBER1 and EBER2 are highly abundant through all four latency stages of EBV infection (III-II-I-0) and have been associated with an oncogenic phenotype when expressed in cell lines cultured in vitro. In vivo, EBV-infected B cells derived fr...
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American Society for Microbiology
2016
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oai:doaj.org-article:ced2e1d4670b4632b5df2403acefa80d2021-11-15T15:49:40ZConsideration of Epstein-Barr Virus-Encoded Noncoding RNAs EBER1 and EBER2 as a Functional Backup of Viral Oncoprotein Latent Membrane Protein 110.1128/mBio.01926-152150-7511https://doaj.org/article/ced2e1d4670b4632b5df2403acefa80d2016-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01926-15https://doaj.org/toc/2150-7511ABSTRACT The Epstein-Barr virus (EBV)-encoded noncoding RNAs EBER1 and EBER2 are highly abundant through all four latency stages of EBV infection (III-II-I-0) and have been associated with an oncogenic phenotype when expressed in cell lines cultured in vitro. In vivo, EBV-infected B cells derived from freshly isolated lymphocytes show that EBER1/2 deletion does not impair viral latency. Based on published quantitative proteomics data from BJAB cells expressing EBER1 and EBER2, we propose that the EBERs, through their activation of AKT in a B-cell-specific manner, are a functionally redundant backup of latent membrane protein 1 (LMP1)—an essential oncoprotein in EBV-associated malignancies, with a main role in AKT activation. Our proposed model may explain the lack of effect on viral latency establishment in EBER-minus EBV infection.Kristina M. HerbertGenaro PimientaAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 1 (2016) |
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Microbiology QR1-502 |
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Microbiology QR1-502 Kristina M. Herbert Genaro Pimienta Consideration of Epstein-Barr Virus-Encoded Noncoding RNAs EBER1 and EBER2 as a Functional Backup of Viral Oncoprotein Latent Membrane Protein 1 |
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ABSTRACT The Epstein-Barr virus (EBV)-encoded noncoding RNAs EBER1 and EBER2 are highly abundant through all four latency stages of EBV infection (III-II-I-0) and have been associated with an oncogenic phenotype when expressed in cell lines cultured in vitro. In vivo, EBV-infected B cells derived from freshly isolated lymphocytes show that EBER1/2 deletion does not impair viral latency. Based on published quantitative proteomics data from BJAB cells expressing EBER1 and EBER2, we propose that the EBERs, through their activation of AKT in a B-cell-specific manner, are a functionally redundant backup of latent membrane protein 1 (LMP1)—an essential oncoprotein in EBV-associated malignancies, with a main role in AKT activation. Our proposed model may explain the lack of effect on viral latency establishment in EBER-minus EBV infection. |
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article |
author |
Kristina M. Herbert Genaro Pimienta |
author_facet |
Kristina M. Herbert Genaro Pimienta |
author_sort |
Kristina M. Herbert |
title |
Consideration of Epstein-Barr Virus-Encoded Noncoding RNAs EBER1 and EBER2 as a Functional Backup of Viral Oncoprotein Latent Membrane Protein 1 |
title_short |
Consideration of Epstein-Barr Virus-Encoded Noncoding RNAs EBER1 and EBER2 as a Functional Backup of Viral Oncoprotein Latent Membrane Protein 1 |
title_full |
Consideration of Epstein-Barr Virus-Encoded Noncoding RNAs EBER1 and EBER2 as a Functional Backup of Viral Oncoprotein Latent Membrane Protein 1 |
title_fullStr |
Consideration of Epstein-Barr Virus-Encoded Noncoding RNAs EBER1 and EBER2 as a Functional Backup of Viral Oncoprotein Latent Membrane Protein 1 |
title_full_unstemmed |
Consideration of Epstein-Barr Virus-Encoded Noncoding RNAs EBER1 and EBER2 as a Functional Backup of Viral Oncoprotein Latent Membrane Protein 1 |
title_sort |
consideration of epstein-barr virus-encoded noncoding rnas eber1 and eber2 as a functional backup of viral oncoprotein latent membrane protein 1 |
publisher |
American Society for Microbiology |
publishDate |
2016 |
url |
https://doaj.org/article/ced2e1d4670b4632b5df2403acefa80d |
work_keys_str_mv |
AT kristinamherbert considerationofepsteinbarrvirusencodednoncodingrnaseber1andeber2asafunctionalbackupofviraloncoproteinlatentmembraneprotein1 AT genaropimienta considerationofepsteinbarrvirusencodednoncodingrnaseber1andeber2asafunctionalbackupofviraloncoproteinlatentmembraneprotein1 |
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1718427487412682752 |