BOLD signal response in primary visual cortex to flickering checkerboard increases with stimulus temporal frequency in older adults

Many older adults have difficulty seeing brief visual stimuli which younger adults can easily recognize. The primary visual cortex (V1) may induce this difficulty. However, in neuroimaging studies, the V1 response change to the increase of temporal frequency of visual stimulus in older adults was un...

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Autores principales:	Yuji Uchiyama, Hiroyuki Sakai, Takafumi Ando, Atsumichi Tachibana, Norihiro Sadato
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ced75281676f4e76a6a3541aeec7249f
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spelling	oai:doaj.org-article:ced75281676f4e76a6a3541aeec7249f2021-11-11T07:14:37ZBOLD signal response in primary visual cortex to flickering checkerboard increases with stimulus temporal frequency in older adults1932-6203https://doaj.org/article/ced75281676f4e76a6a3541aeec7249f2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568270/?tool=EBIhttps://doaj.org/toc/1932-6203Many older adults have difficulty seeing brief visual stimuli which younger adults can easily recognize. The primary visual cortex (V1) may induce this difficulty. However, in neuroimaging studies, the V1 response change to the increase of temporal frequency of visual stimulus in older adults was unclear. Here we investigated the association between the temporal frequency of flickering stimuli and the BOLD activity within V1 in older adults, using surface-based fMRI analysis. The fMRI data from 29 healthy older participants stimulated by contrast-reversing checkerboard at temporal flicker frequencies of 2, 4, and 8 Hz were obtained. The participants also performed a useful field of view (UFOV) test. The slope coefficient of BOLD activity regarding the temporal frequency of the visual stimulus averaged within V1 regions of interest was positive and significantly different from zero. Group analysis in the V1 showed significant clusters with positive slope and no significant clusters with a negative slope. The correlation coefficient between the slope coefficient and UFOV performance was not significant. The results indicated that V1 BOLD response to a flickering visual stimulus increases as the stimulus temporal frequency increases from 2 to 8 Hz in older adults.Yuji UchiyamaHiroyuki SakaiTakafumi AndoAtsumichi TachibanaNorihiro SadatoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuji Uchiyama Hiroyuki Sakai Takafumi Ando Atsumichi Tachibana Norihiro Sadato BOLD signal response in primary visual cortex to flickering checkerboard increases with stimulus temporal frequency in older adults
description	Many older adults have difficulty seeing brief visual stimuli which younger adults can easily recognize. The primary visual cortex (V1) may induce this difficulty. However, in neuroimaging studies, the V1 response change to the increase of temporal frequency of visual stimulus in older adults was unclear. Here we investigated the association between the temporal frequency of flickering stimuli and the BOLD activity within V1 in older adults, using surface-based fMRI analysis. The fMRI data from 29 healthy older participants stimulated by contrast-reversing checkerboard at temporal flicker frequencies of 2, 4, and 8 Hz were obtained. The participants also performed a useful field of view (UFOV) test. The slope coefficient of BOLD activity regarding the temporal frequency of the visual stimulus averaged within V1 regions of interest was positive and significantly different from zero. Group analysis in the V1 showed significant clusters with positive slope and no significant clusters with a negative slope. The correlation coefficient between the slope coefficient and UFOV performance was not significant. The results indicated that V1 BOLD response to a flickering visual stimulus increases as the stimulus temporal frequency increases from 2 to 8 Hz in older adults.
format	article
author	Yuji Uchiyama Hiroyuki Sakai Takafumi Ando Atsumichi Tachibana Norihiro Sadato
author_facet	Yuji Uchiyama Hiroyuki Sakai Takafumi Ando Atsumichi Tachibana Norihiro Sadato
author_sort	Yuji Uchiyama
title	BOLD signal response in primary visual cortex to flickering checkerboard increases with stimulus temporal frequency in older adults
title_short	BOLD signal response in primary visual cortex to flickering checkerboard increases with stimulus temporal frequency in older adults
title_full	BOLD signal response in primary visual cortex to flickering checkerboard increases with stimulus temporal frequency in older adults
title_fullStr	BOLD signal response in primary visual cortex to flickering checkerboard increases with stimulus temporal frequency in older adults
title_full_unstemmed	BOLD signal response in primary visual cortex to flickering checkerboard increases with stimulus temporal frequency in older adults
title_sort	bold signal response in primary visual cortex to flickering checkerboard increases with stimulus temporal frequency in older adults
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ced75281676f4e76a6a3541aeec7249f
work_keys_str_mv	AT yujiuchiyama boldsignalresponseinprimaryvisualcortextoflickeringcheckerboardincreaseswithstimulustemporalfrequencyinolderadults AT hiroyukisakai boldsignalresponseinprimaryvisualcortextoflickeringcheckerboardincreaseswithstimulustemporalfrequencyinolderadults AT takafumiando boldsignalresponseinprimaryvisualcortextoflickeringcheckerboardincreaseswithstimulustemporalfrequencyinolderadults AT atsumichitachibana boldsignalresponseinprimaryvisualcortextoflickeringcheckerboardincreaseswithstimulustemporalfrequencyinolderadults AT norihirosadato boldsignalresponseinprimaryvisualcortextoflickeringcheckerboardincreaseswithstimulustemporalfrequencyinolderadults
_version_	1718439443082248192

BOLD signal response in primary visual cortex to flickering checkerboard increases with stimulus temporal frequency in older adults

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