Coagulation abnormalities in Dengue fever infection: A systematic review and meta-analysis.

<h4>Background</h4>Coagulation mechanisms are reported to be affected in dengue illness and evidenced by prolonged activated partial thromboplastin time (APTT) and prothrombin time (PT). The main aim of this systematic review and meta-analysis is to determine the magnitude of coagulation...

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Autores principales:	Tiruneh Adane, Solomon Getawa
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/ced75dbbc9444384933ce9769d9f1c0f
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spelling	oai:doaj.org-article:ced75dbbc9444384933ce9769d9f1c0f2021-12-02T20:23:38ZCoagulation abnormalities in Dengue fever infection: A systematic review and meta-analysis.1935-27271935-273510.1371/journal.pntd.0009666https://doaj.org/article/ced75dbbc9444384933ce9769d9f1c0f2021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009666https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Coagulation mechanisms are reported to be affected in dengue illness and evidenced by prolonged activated partial thromboplastin time (APTT) and prothrombin time (PT). The main aim of this systematic review and meta-analysis is to determine the magnitude of coagulation abnormalities among patients with dengue fever infection.<h4>Method</h4>This systematic review and meta-analysis were conducted per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The Joana Brigg's Institute (JBI) critical appraisal checklist was used for quality appraisal. STATA version 11 software was used for meta-analysis. The magnitude of coagulation abnormalities among dengue fever patients was determined by using a random-effects model. Subgroup and sensitivity analysis were performed to investigate the possible source of heterogeneity. Egger weighted regression tests were used to check the presence of publication bias among the included articles.<h4>Result</h4>Forty-two studies with a total of 12,221 dengue fever patients were eligible for meta-analysis in this study. Of which 22, 15, and 26 studies were used to determine the magnitude of prolonged APTT, PT, and thrombocytopenia, respectively. The magnitude of prolonged APTT and PT among patients with dengue fever infection were 42.91% (95% CI: 30.95, 54.87) I2 = 99.1% and 16.48% (95% CI: 10.95, 22.01) I2 = 97.0%, respectively. Besides, the magnitude of thrombocytopenia among dengue fever patients was 70.29% (95% CI: 62.69, 77.89) I2 = 99.3%. The magnitude of prolonged APTT in children and adults was 51.21% (95% CI: 24.54, 77.89) and 44.89% (95% CI: 28.32, 61.45), respectively. Similarly, the overall magnitude of prolonged PT in children and adults were 13.40% (95% CI: 6.09, 20.71) and 18.73% (95% CI: 7.49, 29.96), respectively.<h4>Conclusion</h4>The result of this study showed that there is a high magnitude of prolonged APTT and PT in dengue fever patients. Therefore, screening and early correction of coagulation abnormalities may be helpful to reduce further complications in those patients.Tiruneh AdaneSolomon GetawaPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009666 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tiruneh Adane Solomon Getawa Coagulation abnormalities in Dengue fever infection: A systematic review and meta-analysis.
description	<h4>Background</h4>Coagulation mechanisms are reported to be affected in dengue illness and evidenced by prolonged activated partial thromboplastin time (APTT) and prothrombin time (PT). The main aim of this systematic review and meta-analysis is to determine the magnitude of coagulation abnormalities among patients with dengue fever infection.<h4>Method</h4>This systematic review and meta-analysis were conducted per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The Joana Brigg's Institute (JBI) critical appraisal checklist was used for quality appraisal. STATA version 11 software was used for meta-analysis. The magnitude of coagulation abnormalities among dengue fever patients was determined by using a random-effects model. Subgroup and sensitivity analysis were performed to investigate the possible source of heterogeneity. Egger weighted regression tests were used to check the presence of publication bias among the included articles.<h4>Result</h4>Forty-two studies with a total of 12,221 dengue fever patients were eligible for meta-analysis in this study. Of which 22, 15, and 26 studies were used to determine the magnitude of prolonged APTT, PT, and thrombocytopenia, respectively. The magnitude of prolonged APTT and PT among patients with dengue fever infection were 42.91% (95% CI: 30.95, 54.87) I2 = 99.1% and 16.48% (95% CI: 10.95, 22.01) I2 = 97.0%, respectively. Besides, the magnitude of thrombocytopenia among dengue fever patients was 70.29% (95% CI: 62.69, 77.89) I2 = 99.3%. The magnitude of prolonged APTT in children and adults was 51.21% (95% CI: 24.54, 77.89) and 44.89% (95% CI: 28.32, 61.45), respectively. Similarly, the overall magnitude of prolonged PT in children and adults were 13.40% (95% CI: 6.09, 20.71) and 18.73% (95% CI: 7.49, 29.96), respectively.<h4>Conclusion</h4>The result of this study showed that there is a high magnitude of prolonged APTT and PT in dengue fever patients. Therefore, screening and early correction of coagulation abnormalities may be helpful to reduce further complications in those patients.
format	article
author	Tiruneh Adane Solomon Getawa
author_facet	Tiruneh Adane Solomon Getawa
author_sort	Tiruneh Adane
title	Coagulation abnormalities in Dengue fever infection: A systematic review and meta-analysis.
title_short	Coagulation abnormalities in Dengue fever infection: A systematic review and meta-analysis.
title_full	Coagulation abnormalities in Dengue fever infection: A systematic review and meta-analysis.
title_fullStr	Coagulation abnormalities in Dengue fever infection: A systematic review and meta-analysis.
title_full_unstemmed	Coagulation abnormalities in Dengue fever infection: A systematic review and meta-analysis.
title_sort	coagulation abnormalities in dengue fever infection: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ced75dbbc9444384933ce9769d9f1c0f
work_keys_str_mv	AT tirunehadane coagulationabnormalitiesindenguefeverinfectionasystematicreviewandmetaanalysis AT solomongetawa coagulationabnormalitiesindenguefeverinfectionasystematicreviewandmetaanalysis
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Coagulation abnormalities in Dengue fever infection: A systematic review and meta-analysis.

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