Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer

FOXA1 pioneer transcription factor is recurrently mutated in primary and metastatic prostate tumors. Here, authors identify a set of six cis-regulatory elements in the FOXA1 regulatory plexus harboring somatic SNVs in primary prostate tumors and characterize their role in regulating FOXA1 expression...

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Autores principales:	Stanley Zhou, James R. Hawley, Fraser Soares, Giacomo Grillo, Mona Teng, Seyed Ali Madani Tonekaboni, Junjie Tony Hua, Ken J. Kron, Parisa Mazrooei, Musaddeque Ahmed, Christopher Arlidge, Hwa Young Yun, Julie Livingstone, Vincent Huang, Takafumi N. Yamaguchi, Shadrielle M. G. Espiritu, Yanyun Zhu, Tesa M. Severson, Alex Murison, Sarina Cameron, Wilbert Zwart, Theodorus van der Kwast, Trevor J. Pugh, Michael Fraser, Paul C. Boutros, Robert G. Bristow, Housheng Hansen He, Mathieu Lupien
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ced842dd69954226b920c3219e59c1a5
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spelling	oai:doaj.org-article:ced842dd69954226b920c3219e59c1a52021-12-02T14:41:02ZNoncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer10.1038/s41467-020-14318-92041-1723https://doaj.org/article/ced842dd69954226b920c3219e59c1a52020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14318-9https://doaj.org/toc/2041-1723FOXA1 pioneer transcription factor is recurrently mutated in primary and metastatic prostate tumors. Here, authors identify a set of six cis-regulatory elements in the FOXA1 regulatory plexus harboring somatic SNVs in primary prostate tumors and characterize their role in regulating FOXA1 expression and prostate cancer cell growth.Stanley ZhouJames R. HawleyFraser SoaresGiacomo GrilloMona TengSeyed Ali Madani TonekaboniJunjie Tony HuaKen J. KronParisa MazrooeiMusaddeque AhmedChristopher ArlidgeHwa Young YunJulie LivingstoneVincent HuangTakafumi N. YamaguchiShadrielle M. G. EspirituYanyun ZhuTesa M. SeversonAlex MurisonSarina CameronWilbert ZwartTheodorus van der KwastTrevor J. PughMichael FraserPaul C. BoutrosRobert G. BristowHousheng Hansen HeMathieu LupienNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stanley Zhou James R. Hawley Fraser Soares Giacomo Grillo Mona Teng Seyed Ali Madani Tonekaboni Junjie Tony Hua Ken J. Kron Parisa Mazrooei Musaddeque Ahmed Christopher Arlidge Hwa Young Yun Julie Livingstone Vincent Huang Takafumi N. Yamaguchi Shadrielle M. G. Espiritu Yanyun Zhu Tesa M. Severson Alex Murison Sarina Cameron Wilbert Zwart Theodorus van der Kwast Trevor J. Pugh Michael Fraser Paul C. Boutros Robert G. Bristow Housheng Hansen He Mathieu Lupien Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer
description	FOXA1 pioneer transcription factor is recurrently mutated in primary and metastatic prostate tumors. Here, authors identify a set of six cis-regulatory elements in the FOXA1 regulatory plexus harboring somatic SNVs in primary prostate tumors and characterize their role in regulating FOXA1 expression and prostate cancer cell growth.
format	article
author	Stanley Zhou James R. Hawley Fraser Soares Giacomo Grillo Mona Teng Seyed Ali Madani Tonekaboni Junjie Tony Hua Ken J. Kron Parisa Mazrooei Musaddeque Ahmed Christopher Arlidge Hwa Young Yun Julie Livingstone Vincent Huang Takafumi N. Yamaguchi Shadrielle M. G. Espiritu Yanyun Zhu Tesa M. Severson Alex Murison Sarina Cameron Wilbert Zwart Theodorus van der Kwast Trevor J. Pugh Michael Fraser Paul C. Boutros Robert G. Bristow Housheng Hansen He Mathieu Lupien
author_facet	Stanley Zhou James R. Hawley Fraser Soares Giacomo Grillo Mona Teng Seyed Ali Madani Tonekaboni Junjie Tony Hua Ken J. Kron Parisa Mazrooei Musaddeque Ahmed Christopher Arlidge Hwa Young Yun Julie Livingstone Vincent Huang Takafumi N. Yamaguchi Shadrielle M. G. Espiritu Yanyun Zhu Tesa M. Severson Alex Murison Sarina Cameron Wilbert Zwart Theodorus van der Kwast Trevor J. Pugh Michael Fraser Paul C. Boutros Robert G. Bristow Housheng Hansen He Mathieu Lupien
author_sort	Stanley Zhou
title	Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer
title_short	Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer
title_full	Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer
title_fullStr	Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer
title_full_unstemmed	Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer
title_sort	noncoding mutations target cis-regulatory elements of the foxa1 plexus in prostate cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ced842dd69954226b920c3219e59c1a5
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Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer

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