Recovery of the maternal skeleton after lactation is impaired by advanced maternal age but not by reduced IGF availability in the mouse.

<h4>Background</h4>Lactation results in substantial maternal bone loss that is recovered following weaning. However, the mechanisms underlying this recovery, and in particular the role of insulin-like growth factor 1 (IGF-I), is not clear. Furthermore, there is little data regarding whet...

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Autores principales:	Monika D Rogowska, Uriel N V Pena, Nimrat Binning, Julian K Christians
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ced86559f02a4d56b54ca3a82a1c77e0
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spelling	oai:doaj.org-article:ced86559f02a4d56b54ca3a82a1c77e02021-12-02T20:08:41ZRecovery of the maternal skeleton after lactation is impaired by advanced maternal age but not by reduced IGF availability in the mouse.1932-620310.1371/journal.pone.0256906https://doaj.org/article/ced86559f02a4d56b54ca3a82a1c77e02021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256906https://doaj.org/toc/1932-6203<h4>Background</h4>Lactation results in substantial maternal bone loss that is recovered following weaning. However, the mechanisms underlying this recovery, and in particular the role of insulin-like growth factor 1 (IGF-I), is not clear. Furthermore, there is little data regarding whether recovery is affected by advanced maternal age.<h4>Methods</h4>Using micro-computed tomography, we studied bone recovery following lactation in mice at 2, 5 and 7 months of age. We also investigated the effects of reduced IGF-I availability using mice lacking PAPP-A2, a protease of insulin-like growth factor binding protein 5 (IGFBP-5).<h4>Results</h4>In 2 month old mice, lactation affected femoral trabecular and cortical bone, but only cortical bone showed recovery 3 weeks after weaning. This recovery was not affected by deletion of the Pappa2 gene. The amount of trabecular bone was reduced in 5 and 7 month old mice, and was not further reduced by lactation. However, the recovery of cortical bone was impaired at 5 and 7 months compared with at 2 months.<h4>Conclusions</h4>Recovery of the maternal skeleton after lactation is impaired in moderately-aged mice compared with younger mice. Our results may be relevant to the long-term effects of breastfeeding on the maternal skeleton in humans, particularly given the increasing median maternal age at childbearing.Monika D RogowskaUriel N V PenaNimrat BinningJulian K ChristiansPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256906 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Monika D Rogowska Uriel N V Pena Nimrat Binning Julian K Christians Recovery of the maternal skeleton after lactation is impaired by advanced maternal age but not by reduced IGF availability in the mouse.
description	<h4>Background</h4>Lactation results in substantial maternal bone loss that is recovered following weaning. However, the mechanisms underlying this recovery, and in particular the role of insulin-like growth factor 1 (IGF-I), is not clear. Furthermore, there is little data regarding whether recovery is affected by advanced maternal age.<h4>Methods</h4>Using micro-computed tomography, we studied bone recovery following lactation in mice at 2, 5 and 7 months of age. We also investigated the effects of reduced IGF-I availability using mice lacking PAPP-A2, a protease of insulin-like growth factor binding protein 5 (IGFBP-5).<h4>Results</h4>In 2 month old mice, lactation affected femoral trabecular and cortical bone, but only cortical bone showed recovery 3 weeks after weaning. This recovery was not affected by deletion of the Pappa2 gene. The amount of trabecular bone was reduced in 5 and 7 month old mice, and was not further reduced by lactation. However, the recovery of cortical bone was impaired at 5 and 7 months compared with at 2 months.<h4>Conclusions</h4>Recovery of the maternal skeleton after lactation is impaired in moderately-aged mice compared with younger mice. Our results may be relevant to the long-term effects of breastfeeding on the maternal skeleton in humans, particularly given the increasing median maternal age at childbearing.
format	article
author	Monika D Rogowska Uriel N V Pena Nimrat Binning Julian K Christians
author_facet	Monika D Rogowska Uriel N V Pena Nimrat Binning Julian K Christians
author_sort	Monika D Rogowska
title	Recovery of the maternal skeleton after lactation is impaired by advanced maternal age but not by reduced IGF availability in the mouse.
title_short	Recovery of the maternal skeleton after lactation is impaired by advanced maternal age but not by reduced IGF availability in the mouse.
title_full	Recovery of the maternal skeleton after lactation is impaired by advanced maternal age but not by reduced IGF availability in the mouse.
title_fullStr	Recovery of the maternal skeleton after lactation is impaired by advanced maternal age but not by reduced IGF availability in the mouse.
title_full_unstemmed	Recovery of the maternal skeleton after lactation is impaired by advanced maternal age but not by reduced IGF availability in the mouse.
title_sort	recovery of the maternal skeleton after lactation is impaired by advanced maternal age but not by reduced igf availability in the mouse.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ced86559f02a4d56b54ca3a82a1c77e0
work_keys_str_mv	AT monikadrogowska recoveryofthematernalskeletonafterlactationisimpairedbyadvancedmaternalagebutnotbyreducedigfavailabilityinthemouse AT urielnvpena recoveryofthematernalskeletonafterlactationisimpairedbyadvancedmaternalagebutnotbyreducedigfavailabilityinthemouse AT nimratbinning recoveryofthematernalskeletonafterlactationisimpairedbyadvancedmaternalagebutnotbyreducedigfavailabilityinthemouse AT juliankchristians recoveryofthematernalskeletonafterlactationisimpairedbyadvancedmaternalagebutnotbyreducedigfavailabilityinthemouse
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Recovery of the maternal skeleton after lactation is impaired by advanced maternal age but not by reduced IGF availability in the mouse.

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