Eosinophilia characterized by a rare CCT6B mutation and responsive to tyrosine kinase inhibition: Case report and literature review

Hypereosinophilic syndrome is a rare disorder arising from neoplastic, or idiopathic causes. The availability of NGS panels has increasingly identified rare mutations as underlying pathogenic events and have led to reclassification of cases of idiopathic hypereosinophilic syndrome as chronic eosinop...

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Autores principales:	Abhay Singh, Jeffrey Baron, Namrata Singh, Gopisree Peringeth, Eunice S. Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Idiopathic hypereosinophilic syndrome (IHES) Chronic eosinophilic leukemia-not otherwise specified (CEL-NOS) CCT6B Imatinib Dasitinib Nilotinib Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ced9087a1af54ce2b9f7ccbc3357c4de
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spelling	oai:doaj.org-article:ced9087a1af54ce2b9f7ccbc3357c4de2021-11-12T04:32:55ZEosinophilia characterized by a rare CCT6B mutation and responsive to tyrosine kinase inhibition: Case report and literature review2213-048910.1016/j.lrr.2021.100279https://doaj.org/article/ced9087a1af54ce2b9f7ccbc3357c4de2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213048921000467https://doaj.org/toc/2213-0489Hypereosinophilic syndrome is a rare disorder arising from neoplastic, or idiopathic causes. The availability of NGS panels has increasingly identified rare mutations as underlying pathogenic events and have led to reclassification of cases of idiopathic hypereosinophilic syndrome as chronic eosinophilic leukemia(CEL). In this report, we describe a case of a young man with hypereosinophilia whose disease initially did not fit the WHO criteria for CEL but harbored a rare mutation in CCT6B gene. We report our experience in successfully treating this patient with multiple tyrosine kinase inhibitors and provide literature review of this rare entity including potential treatment strategies.Abhay SinghJeffrey BaronNamrata SinghGopisree PeringethEunice S. WangElsevierarticleIdiopathic hypereosinophilic syndrome (IHES)Chronic eosinophilic leukemia-not otherwise specified (CEL-NOS)CCT6BImatinibDasitinibNilotinibNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLeukemia Research Reports, Vol 16, Iss , Pp 100279- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Idiopathic hypereosinophilic syndrome (IHES) Chronic eosinophilic leukemia-not otherwise specified (CEL-NOS) CCT6B Imatinib Dasitinib Nilotinib Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Idiopathic hypereosinophilic syndrome (IHES) Chronic eosinophilic leukemia-not otherwise specified (CEL-NOS) CCT6B Imatinib Dasitinib Nilotinib Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Abhay Singh Jeffrey Baron Namrata Singh Gopisree Peringeth Eunice S. Wang Eosinophilia characterized by a rare CCT6B mutation and responsive to tyrosine kinase inhibition: Case report and literature review
description	Hypereosinophilic syndrome is a rare disorder arising from neoplastic, or idiopathic causes. The availability of NGS panels has increasingly identified rare mutations as underlying pathogenic events and have led to reclassification of cases of idiopathic hypereosinophilic syndrome as chronic eosinophilic leukemia(CEL). In this report, we describe a case of a young man with hypereosinophilia whose disease initially did not fit the WHO criteria for CEL but harbored a rare mutation in CCT6B gene. We report our experience in successfully treating this patient with multiple tyrosine kinase inhibitors and provide literature review of this rare entity including potential treatment strategies.
format	article
author	Abhay Singh Jeffrey Baron Namrata Singh Gopisree Peringeth Eunice S. Wang
author_facet	Abhay Singh Jeffrey Baron Namrata Singh Gopisree Peringeth Eunice S. Wang
author_sort	Abhay Singh
title	Eosinophilia characterized by a rare CCT6B mutation and responsive to tyrosine kinase inhibition: Case report and literature review
title_short	Eosinophilia characterized by a rare CCT6B mutation and responsive to tyrosine kinase inhibition: Case report and literature review
title_full	Eosinophilia characterized by a rare CCT6B mutation and responsive to tyrosine kinase inhibition: Case report and literature review
title_fullStr	Eosinophilia characterized by a rare CCT6B mutation and responsive to tyrosine kinase inhibition: Case report and literature review
title_full_unstemmed	Eosinophilia characterized by a rare CCT6B mutation and responsive to tyrosine kinase inhibition: Case report and literature review
title_sort	eosinophilia characterized by a rare cct6b mutation and responsive to tyrosine kinase inhibition: case report and literature review
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ced9087a1af54ce2b9f7ccbc3357c4de
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Eosinophilia characterized by a rare CCT6B mutation and responsive to tyrosine kinase inhibition: Case report and literature review

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