Low Levels of High-density Lipoprotein in Patients with Pediatric Cancer at Diagnosis

Introduction: Cancer patients have metabolic imbalances due to the disease, treatment and their complications. Increases in triglycerides and glucose profile and catabolism of protein have been described and are associated with inflammatory response as result of the tumor activity or necrosis. Obje...

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Autores principales:	Adriana Garófolo, Priscila dos Santos Maia-Lemos
Formato:	article
Lenguaje:	EN PT
Publicado:	Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) 2020
Materias:	Triglycerides/blood Cholesterol, HDL/blood Blood Glucose Serum Albumin Neoplasms Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/cedb8183dd7949d7ae9cea507216ac48
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spelling	oai:doaj.org-article:cedb8183dd7949d7ae9cea507216ac482021-11-29T20:03:24ZLow Levels of High-density Lipoprotein in Patients with Pediatric Cancer at Diagnosis10.32635/2176-9745.RBC.2019v65n3.5280034-71162176-9745https://doaj.org/article/cedb8183dd7949d7ae9cea507216ac482020-01-01T00:00:00Zhttps://rbc.inca.gov.br/revista/index.php/revista/article/view/528https://doaj.org/toc/0034-7116https://doaj.org/toc/2176-9745 Introduction: Cancer patients have metabolic imbalances due to the disease, treatment and their complications. Increases in triglycerides and glucose profile and catabolism of protein have been described and are associated with inflammatory response as result of the tumor activity or necrosis. Objective: To evaluate the blood lipid, lipoproteins, glucose and albumin levels in pediatric cancer patients at diagnosis. Method: Observational cross-sectional study. The inclusion criteria were children and adolescents with newly diagnosed malignancies and blood analysis results. The exclusion criteria were: previous anticancer therapy or surgical treatment, blood sample not collected and patients who refused to participate in the study. Results: It were evaluated 81 children and adolescents with newly diagnosed malignancies. There was decrease of 56% and 41% of high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG), 14% and 10% of albumin and glucose, and 10% and 7.6% of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), respectively, for the patients. HDL-C showed statistical differences between solid and hematological cancer patients (p < 0.05). The means and medians of albumin, glucose, HDL-C and TG demonstrated that hematological patients are more prone to metabolic disturbances. HDL-C in this group was 24 ± 12 versus 40 ± 15mg/dl in other cancers. Conclusion: The primary result found in the present study was in HDL-C, mainly in patients with hematological and metastatic cancer. These disturbances could be associated with cancer-related acute inflammatory response. Adriana GarófoloPriscila dos Santos Maia-LemosInstituto Nacional de Câncer José Alencar Gomes da Silva (INCA)articleTriglycerides/bloodCholesterol, HDL/bloodBlood GlucoseSerum AlbuminNeoplasmsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENPTRevista Brasileira de Cancerologia, Vol 65, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN PT
topic	Triglycerides/blood Cholesterol, HDL/blood Blood Glucose Serum Albumin Neoplasms Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Triglycerides/blood Cholesterol, HDL/blood Blood Glucose Serum Albumin Neoplasms Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Adriana Garófolo Priscila dos Santos Maia-Lemos Low Levels of High-density Lipoprotein in Patients with Pediatric Cancer at Diagnosis
description	Introduction: Cancer patients have metabolic imbalances due to the disease, treatment and their complications. Increases in triglycerides and glucose profile and catabolism of protein have been described and are associated with inflammatory response as result of the tumor activity or necrosis. Objective: To evaluate the blood lipid, lipoproteins, glucose and albumin levels in pediatric cancer patients at diagnosis. Method: Observational cross-sectional study. The inclusion criteria were children and adolescents with newly diagnosed malignancies and blood analysis results. The exclusion criteria were: previous anticancer therapy or surgical treatment, blood sample not collected and patients who refused to participate in the study. Results: It were evaluated 81 children and adolescents with newly diagnosed malignancies. There was decrease of 56% and 41% of high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG), 14% and 10% of albumin and glucose, and 10% and 7.6% of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), respectively, for the patients. HDL-C showed statistical differences between solid and hematological cancer patients (p < 0.05). The means and medians of albumin, glucose, HDL-C and TG demonstrated that hematological patients are more prone to metabolic disturbances. HDL-C in this group was 24 ± 12 versus 40 ± 15mg/dl in other cancers. Conclusion: The primary result found in the present study was in HDL-C, mainly in patients with hematological and metastatic cancer. These disturbances could be associated with cancer-related acute inflammatory response.
format	article
author	Adriana Garófolo Priscila dos Santos Maia-Lemos
author_facet	Adriana Garófolo Priscila dos Santos Maia-Lemos
author_sort	Adriana Garófolo
title	Low Levels of High-density Lipoprotein in Patients with Pediatric Cancer at Diagnosis
title_short	Low Levels of High-density Lipoprotein in Patients with Pediatric Cancer at Diagnosis
title_full	Low Levels of High-density Lipoprotein in Patients with Pediatric Cancer at Diagnosis
title_fullStr	Low Levels of High-density Lipoprotein in Patients with Pediatric Cancer at Diagnosis
title_full_unstemmed	Low Levels of High-density Lipoprotein in Patients with Pediatric Cancer at Diagnosis
title_sort	low levels of high-density lipoprotein in patients with pediatric cancer at diagnosis
publisher	Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
publishDate	2020
url	https://doaj.org/article/cedb8183dd7949d7ae9cea507216ac48
work_keys_str_mv	AT adrianagarofolo lowlevelsofhighdensitylipoproteininpatientswithpediatriccanceratdiagnosis AT prisciladossantosmaialemos lowlevelsofhighdensitylipoproteininpatientswithpediatriccanceratdiagnosis
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Low Levels of High-density Lipoprotein in Patients with Pediatric Cancer at Diagnosis

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