Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection

The conversion of auditory and vestibular stimuli into electrical signals is initiated by force transmitted to a mechanotransduction channel through the tip link. Here authors show that a single tip-link bond is more mechanically stable relative to classic cadherins, and that the double stranded tip...

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Autores principales:	Eric M. Mulhall, Andrew Ward, Darren Yang, Mounir A. Koussa, David P. Corey, Wesley P. Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cedc8ced7e7c4b7984736d122c8d046c
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spelling	oai:doaj.org-article:cedc8ced7e7c4b7984736d122c8d046c2021-12-02T14:11:08ZSingle-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection10.1038/s41467-021-21033-62041-1723https://doaj.org/article/cedc8ced7e7c4b7984736d122c8d046c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21033-6https://doaj.org/toc/2041-1723The conversion of auditory and vestibular stimuli into electrical signals is initiated by force transmitted to a mechanotransduction channel through the tip link. Here authors show that a single tip-link bond is more mechanically stable relative to classic cadherins, and that the double stranded tip-link connection is stabilized by single strand rebinding facilitated by strong cis-dimerization domains.Eric M. MulhallAndrew WardDarren YangMounir A. KoussaDavid P. CoreyWesley P. WongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eric M. Mulhall Andrew Ward Darren Yang Mounir A. Koussa David P. Corey Wesley P. Wong Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection
description	The conversion of auditory and vestibular stimuli into electrical signals is initiated by force transmitted to a mechanotransduction channel through the tip link. Here authors show that a single tip-link bond is more mechanically stable relative to classic cadherins, and that the double stranded tip-link connection is stabilized by single strand rebinding facilitated by strong cis-dimerization domains.
format	article
author	Eric M. Mulhall Andrew Ward Darren Yang Mounir A. Koussa David P. Corey Wesley P. Wong
author_facet	Eric M. Mulhall Andrew Ward Darren Yang Mounir A. Koussa David P. Corey Wesley P. Wong
author_sort	Eric M. Mulhall
title	Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection
title_short	Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection
title_full	Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection
title_fullStr	Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection
title_full_unstemmed	Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection
title_sort	single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cedc8ced7e7c4b7984736d122c8d046c
work_keys_str_mv	AT ericmmulhall singlemoleculeforcespectroscopyrevealsthedynamicstrengthofthehaircelltiplinkconnection AT andrewward singlemoleculeforcespectroscopyrevealsthedynamicstrengthofthehaircelltiplinkconnection AT darrenyang singlemoleculeforcespectroscopyrevealsthedynamicstrengthofthehaircelltiplinkconnection AT mounirakoussa singlemoleculeforcespectroscopyrevealsthedynamicstrengthofthehaircelltiplinkconnection AT davidpcorey singlemoleculeforcespectroscopyrevealsthedynamicstrengthofthehaircelltiplinkconnection AT wesleypwong singlemoleculeforcespectroscopyrevealsthedynamicstrengthofthehaircelltiplinkconnection
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Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection

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