Recent Research Progress (2015–2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA

Tanshinone IIA (Tan IIA) is an important characteristic component and active ingredient in Salvia miltiorrhiza, and its various aspects of research are constantly being updated to explore its potential application. In this paper, we review the recent progress on pharmacological activities and the th...

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Autores principales:	Chenhui Zhong, Zuan Lin, Liyuan Ke, Peiying Shi, Shaoguang Li, Liying Huang, Xinhua Lin, Hong Yao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tanshinone IIA molecular mechanism pharmacological effects pharmacokinetics bioinformatic analysis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/cede77adf6334cb4b5852a00a441fe8e
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spelling	oai:doaj.org-article:cede77adf6334cb4b5852a00a441fe8e2021-11-08T06:41:26ZRecent Research Progress (2015–2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA1663-981210.3389/fphar.2021.778847https://doaj.org/article/cede77adf6334cb4b5852a00a441fe8e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.778847/fullhttps://doaj.org/toc/1663-9812Tanshinone IIA (Tan IIA) is an important characteristic component and active ingredient in Salvia miltiorrhiza, and its various aspects of research are constantly being updated to explore its potential application. In this paper, we review the recent progress on pharmacological activities and the therapeutic mechanisms of Tan IIA according to literature during the years 2015–2021. Tan IIA shows multiple pharmacological effects, including anticarcinogenic, cardiovascular, nervous, respiratory, urinary, digestive, and motor systems activities. Tan IIA modulates multi-targets referring to Nrf2, AMPK, GSK-3β, EGFR, CD36, HO-1, NOX4, Beclin-1, TLR4, TNF-α, STAT3, Caspase-3, and bcl-2 proteins and multi-pathways including NF-κB, SIRT1/PGC1α, MAPK, SREBP-2/Pcsk9, Wnt, PI3K/Akt/mTOR pathways, TGF-β/Smad and Hippo/YAP pathways, etc., which directly or indirectly influence disease course. Further, with the reported targets, the potential effects and possible mechanisms of Tan IIA against diseases were predicted by bioinformatic analysis. This paper provides new insights into the therapeutic effects and mechanisms of Tan IIA against diseases.Chenhui ZhongZuan LinLiyuan KePeiying ShiShaoguang LiLiying HuangXinhua LinXinhua LinHong YaoHong YaoHong YaoFrontiers Media S.A.articletanshinone IIAmolecular mechanismpharmacological effectspharmacokineticsbioinformatic analysisTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tanshinone IIA molecular mechanism pharmacological effects pharmacokinetics bioinformatic analysis Therapeutics. Pharmacology RM1-950
spellingShingle	tanshinone IIA molecular mechanism pharmacological effects pharmacokinetics bioinformatic analysis Therapeutics. Pharmacology RM1-950 Chenhui Zhong Zuan Lin Liyuan Ke Peiying Shi Shaoguang Li Liying Huang Xinhua Lin Xinhua Lin Hong Yao Hong Yao Hong Yao Recent Research Progress (2015–2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA
description	Tanshinone IIA (Tan IIA) is an important characteristic component and active ingredient in Salvia miltiorrhiza, and its various aspects of research are constantly being updated to explore its potential application. In this paper, we review the recent progress on pharmacological activities and the therapeutic mechanisms of Tan IIA according to literature during the years 2015–2021. Tan IIA shows multiple pharmacological effects, including anticarcinogenic, cardiovascular, nervous, respiratory, urinary, digestive, and motor systems activities. Tan IIA modulates multi-targets referring to Nrf2, AMPK, GSK-3β, EGFR, CD36, HO-1, NOX4, Beclin-1, TLR4, TNF-α, STAT3, Caspase-3, and bcl-2 proteins and multi-pathways including NF-κB, SIRT1/PGC1α, MAPK, SREBP-2/Pcsk9, Wnt, PI3K/Akt/mTOR pathways, TGF-β/Smad and Hippo/YAP pathways, etc., which directly or indirectly influence disease course. Further, with the reported targets, the potential effects and possible mechanisms of Tan IIA against diseases were predicted by bioinformatic analysis. This paper provides new insights into the therapeutic effects and mechanisms of Tan IIA against diseases.
format	article
author	Chenhui Zhong Zuan Lin Liyuan Ke Peiying Shi Shaoguang Li Liying Huang Xinhua Lin Xinhua Lin Hong Yao Hong Yao Hong Yao
author_facet	Chenhui Zhong Zuan Lin Liyuan Ke Peiying Shi Shaoguang Li Liying Huang Xinhua Lin Xinhua Lin Hong Yao Hong Yao Hong Yao
author_sort	Chenhui Zhong
title	Recent Research Progress (2015–2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA
title_short	Recent Research Progress (2015–2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA
title_full	Recent Research Progress (2015–2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA
title_fullStr	Recent Research Progress (2015–2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA
title_full_unstemmed	Recent Research Progress (2015–2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA
title_sort	recent research progress (2015–2021) and perspectives on the pharmacological effects and mechanisms of tanshinone iia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cede77adf6334cb4b5852a00a441fe8e
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Recent Research Progress (2015–2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA

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