A rare case of type 4 rapidly progressive glomerulonephritis (atypical) with mesangial IgA deposits: A case report

Rapidly progressive glomerulonephritis can result from glomerular deposition of anti-GBM antibody, immune complexes, or may involve pauci-immune mechanisms. The coexistence of IgA nephropathy, anti-GBM, and anti-neutrophilic cytoplasmic antibodies is unheard of, and the pathogenic role of these anti...

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Autores principales:	Puneet Bhuwania, Ilangovan Veerappan, Ramaswami Sethuraman
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	anti-gbm anca crescents iga nephropathy rapidly progressive glomerulonephritis Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/cee11fef60f74b319724d9f3a35e3dca
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spelling	oai:doaj.org-article:cee11fef60f74b319724d9f3a35e3dca2021-12-02T17:49:11ZA rare case of type 4 rapidly progressive glomerulonephritis (atypical) with mesangial IgA deposits: A case report0971-40651998-366210.4103/ijn.IJN_364_20https://doaj.org/article/cee11fef60f74b319724d9f3a35e3dca2021-01-01T00:00:00Zhttp://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=5;spage=488;epage=491;aulast=Bhuwaniahttps://doaj.org/toc/0971-4065https://doaj.org/toc/1998-3662Rapidly progressive glomerulonephritis can result from glomerular deposition of anti-GBM antibody, immune complexes, or may involve pauci-immune mechanisms. The coexistence of IgA nephropathy, anti-GBM, and anti-neutrophilic cytoplasmic antibodies is unheard of, and the pathogenic role of these antibodies in IgA nephropathy or vice versa remains unclear. Herein, we describe a case of a patient with type 4 rapidly progressive glomerulonephritis who was found to have significant mesangial IgA deposits. The prognosis of this remains unclear but our patient responded well to cytotoxic therapy and plasmapheresis and achieved remission by 6 months. The findings suggest an overlap syndrome of IgA nephropathy-associated type 4 crescentic glomerulonephritis that resembles the former histologically and the latter in its potential to respond to aggressive therapy if detected relatively early in its course.Puneet BhuwaniaIlangovan VeerappanRamaswami SethuramanWolters Kluwer Medknow Publicationsarticleanti-gbmancacrescentsiga nephropathyrapidly progressive glomerulonephritisDiseases of the genitourinary system. UrologyRC870-923ENIndian Journal of Nephrology, Vol 31, Iss 5, Pp 488-491 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-gbm anca crescents iga nephropathy rapidly progressive glomerulonephritis Diseases of the genitourinary system. Urology RC870-923
spellingShingle	anti-gbm anca crescents iga nephropathy rapidly progressive glomerulonephritis Diseases of the genitourinary system. Urology RC870-923 Puneet Bhuwania Ilangovan Veerappan Ramaswami Sethuraman A rare case of type 4 rapidly progressive glomerulonephritis (atypical) with mesangial IgA deposits: A case report
description	Rapidly progressive glomerulonephritis can result from glomerular deposition of anti-GBM antibody, immune complexes, or may involve pauci-immune mechanisms. The coexistence of IgA nephropathy, anti-GBM, and anti-neutrophilic cytoplasmic antibodies is unheard of, and the pathogenic role of these antibodies in IgA nephropathy or vice versa remains unclear. Herein, we describe a case of a patient with type 4 rapidly progressive glomerulonephritis who was found to have significant mesangial IgA deposits. The prognosis of this remains unclear but our patient responded well to cytotoxic therapy and plasmapheresis and achieved remission by 6 months. The findings suggest an overlap syndrome of IgA nephropathy-associated type 4 crescentic glomerulonephritis that resembles the former histologically and the latter in its potential to respond to aggressive therapy if detected relatively early in its course.
format	article
author	Puneet Bhuwania Ilangovan Veerappan Ramaswami Sethuraman
author_facet	Puneet Bhuwania Ilangovan Veerappan Ramaswami Sethuraman
author_sort	Puneet Bhuwania
title	A rare case of type 4 rapidly progressive glomerulonephritis (atypical) with mesangial IgA deposits: A case report
title_short	A rare case of type 4 rapidly progressive glomerulonephritis (atypical) with mesangial IgA deposits: A case report
title_full	A rare case of type 4 rapidly progressive glomerulonephritis (atypical) with mesangial IgA deposits: A case report
title_fullStr	A rare case of type 4 rapidly progressive glomerulonephritis (atypical) with mesangial IgA deposits: A case report
title_full_unstemmed	A rare case of type 4 rapidly progressive glomerulonephritis (atypical) with mesangial IgA deposits: A case report
title_sort	rare case of type 4 rapidly progressive glomerulonephritis (atypical) with mesangial iga deposits: a case report
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/cee11fef60f74b319724d9f3a35e3dca
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A rare case of type 4 rapidly progressive glomerulonephritis (atypical) with mesangial IgA deposits: A case report

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