The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes

Abstract Chemical and mechanical cues from the cerebrospinal fluid (CSF) can affect the development and function of the central nervous system (CNS). How such cues are detected and relayed to the CNS remains elusive. Cerebrospinal fluid-contacting neurons (CSF-cNs) situated at the interface between...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lydia Djenoune, Laura Desban, Johanna Gomez, Jenna R. Sternberg, Andrew Prendergast, Dominique Langui, Feng B. Quan, Hugo Marnas, Thomas O. Auer, Jean-Paul Rio, Filippo Del Bene, Pierre-Luc Bardet, Claire Wyart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cee34d7591db4642a247a6dcd272d2df
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cee34d7591db4642a247a6dcd272d2df
record_format	dspace
spelling	oai:doaj.org-article:cee34d7591db4642a247a6dcd272d2df2021-12-02T15:04:53ZThe dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes10.1038/s41598-017-00350-12045-2322https://doaj.org/article/cee34d7591db4642a247a6dcd272d2df2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00350-1https://doaj.org/toc/2045-2322Abstract Chemical and mechanical cues from the cerebrospinal fluid (CSF) can affect the development and function of the central nervous system (CNS). How such cues are detected and relayed to the CNS remains elusive. Cerebrospinal fluid-contacting neurons (CSF-cNs) situated at the interface between the CSF and the CNS are ideally located to convey such information to local networks. In the spinal cord, these GABAergic neurons expressing the PKD2L1 channel extend an apical extension into the CSF and an ascending axon in the spinal cord. In zebrafish and mouse spinal CSF-cNs originate from two distinct progenitor domains characterized by distinct cascades of transcription factors. Here we ask whether these neurons with different developmental origins differentiate into cells types with different functional properties. We show in zebrafish larva that the expression of specific markers, the morphology of the apical extension and axonal projections, as well as the neuronal targets contacted by CSF-cN axons, distinguish the two CSF-cN subtypes. Altogether our study demonstrates that the developmental origins of spinal CSF-cNs give rise to two distinct functional populations of sensory neurons. This work opens novel avenues to understand how these subtypes may carry distinct functions related to development of the spinal cord, locomotion and posture.Lydia DjenouneLaura DesbanJohanna GomezJenna R. SternbergAndrew PrendergastDominique LanguiFeng B. QuanHugo MarnasThomas O. AuerJean-Paul RioFilippo Del BenePierre-Luc BardetClaire WyartNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lydia Djenoune Laura Desban Johanna Gomez Jenna R. Sternberg Andrew Prendergast Dominique Langui Feng B. Quan Hugo Marnas Thomas O. Auer Jean-Paul Rio Filippo Del Bene Pierre-Luc Bardet Claire Wyart The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
description	Abstract Chemical and mechanical cues from the cerebrospinal fluid (CSF) can affect the development and function of the central nervous system (CNS). How such cues are detected and relayed to the CNS remains elusive. Cerebrospinal fluid-contacting neurons (CSF-cNs) situated at the interface between the CSF and the CNS are ideally located to convey such information to local networks. In the spinal cord, these GABAergic neurons expressing the PKD2L1 channel extend an apical extension into the CSF and an ascending axon in the spinal cord. In zebrafish and mouse spinal CSF-cNs originate from two distinct progenitor domains characterized by distinct cascades of transcription factors. Here we ask whether these neurons with different developmental origins differentiate into cells types with different functional properties. We show in zebrafish larva that the expression of specific markers, the morphology of the apical extension and axonal projections, as well as the neuronal targets contacted by CSF-cN axons, distinguish the two CSF-cN subtypes. Altogether our study demonstrates that the developmental origins of spinal CSF-cNs give rise to two distinct functional populations of sensory neurons. This work opens novel avenues to understand how these subtypes may carry distinct functions related to development of the spinal cord, locomotion and posture.
format	article
author	Lydia Djenoune Laura Desban Johanna Gomez Jenna R. Sternberg Andrew Prendergast Dominique Langui Feng B. Quan Hugo Marnas Thomas O. Auer Jean-Paul Rio Filippo Del Bene Pierre-Luc Bardet Claire Wyart
author_facet	Lydia Djenoune Laura Desban Johanna Gomez Jenna R. Sternberg Andrew Prendergast Dominique Langui Feng B. Quan Hugo Marnas Thomas O. Auer Jean-Paul Rio Filippo Del Bene Pierre-Luc Bardet Claire Wyart
author_sort	Lydia Djenoune
title	The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
title_short	The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
title_full	The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
title_fullStr	The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
title_full_unstemmed	The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
title_sort	dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cee34d7591db4642a247a6dcd272d2df
work_keys_str_mv	AT lydiadjenoune thedualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT lauradesban thedualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT johannagomez thedualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT jennarsternberg thedualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT andrewprendergast thedualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT dominiquelangui thedualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT fengbquan thedualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT hugomarnas thedualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT thomasoauer thedualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT jeanpaulrio thedualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT filippodelbene thedualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT pierrelucbardet thedualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT clairewyart thedualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT lydiadjenoune dualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT lauradesban dualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT johannagomez dualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT jennarsternberg dualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT andrewprendergast dualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT dominiquelangui dualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT fengbquan dualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT hugomarnas dualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT thomasoauer dualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT jeanpaulrio dualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT filippodelbene dualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT pierrelucbardet dualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes AT clairewyart dualdevelopmentaloriginofspinalcerebrospinalfluidcontactingneuronsgivesrisetodistinctfunctionalsubtypes
_version_	1718389045448409088

The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes

Ejemplares similares