High-Normal Serum Thyrotropin Levels Increased the Risk of Non-Alcoholic Fatty Liver Disease in Euthyroid Subjects with Type 2 Diabetes

Ying Tan,1,* Xixiang Tang,1,2,* Panwei Mu,1 Yi Yang,1 Mei Li,1,2 Yuanpeng Nie,1 Haicheng Li,1 Yanhua Zhu,1 Yanming Chen1 1Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, People&a...

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Autores principales: Tan Y, Tang X, Mu P, Yang Y, Li M, Nie Y, Li H, Zhu Y, Chen Y
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Publicado: Dove Medical Press 2021
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spelling oai:doaj.org-article:cee5608a5c80428b8c44f22b05ea56f02021-12-02T16:07:16ZHigh-Normal Serum Thyrotropin Levels Increased the Risk of Non-Alcoholic Fatty Liver Disease in Euthyroid Subjects with Type 2 Diabetes1178-7007https://doaj.org/article/cee5608a5c80428b8c44f22b05ea56f02021-06-01T00:00:00Zhttps://www.dovepress.com/high-normal-serum-thyrotropin-levels-increased-the-risk-of-non-alcohol-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Ying Tan,1,* Xixiang Tang,1,2,* Panwei Mu,1 Yi Yang,1 Mei Li,1,2 Yuanpeng Nie,1 Haicheng Li,1 Yanhua Zhu,1 Yanming Chen1 1Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, People’s Republic of China; 2VIP medical service center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanming Chen; Yanhua ZhuDepartment of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, Tianhe Road 600, Guangzhou, 510630, People’s Republic of ChinaEmail chyanm@mail.sysu.edu.cn; zhuyanh2@mail.sysu.edu.cnPurpose: The aim of this study was to investigate the association between high-normal thyrotropin (TSH) levels and the prevalence of non-alcoholic fatty liver disease (NAFLD) in euthyroid patients with T2DM.Methods: A total of 2289 euthyroid adults with T2DM were included in this cross-sectional study conducted at the Third Affiliated Hospital of Sun Yat-sen University from January 2016 to December 2018. NAFLD was diagnosed by abdominal ultrasound. Thyroid function parameters, including the levels of TSH, free triiodothyronine (FT3) and free thyroxine (FT4), were analyzed. The patients were stratified by quartiles (Q1-4) of TSH levels. Multivariate logistic regression models were used to evaluate the association between the quartiles of TSH levels and the risk of NAFLD in euthyroid adults with T2DM.Results: There were 940 (41.1%) euthyroid adults with T2DM who were diagnosed with NAFLD. The subjects were divided according to the thyroid function parameter quartiles. The prevalence of NAFLD increased with increasing TSH level quartiles (Q1 to Q4: 34.8%, 37.5%, 44.9% and 47.0%, P< 0.01) but not with increasing FT3 or FT4 level quartiles. In the multivariate logistic regression model, compared with the lowest TSH level quartile (Q1), the highest TSH level quartile (Q4) (OR=1.610, 95% CI=1.131– 2.289, P=0.008) was independently associated with an increased risk of NAFLD in euthyroid adults with T2DM after adjusting for multiple confounders. After additional stratification by the level of glycosylated haemoglobin (HbA1c) and body mass index (BMI), the highest TSH level quartile was still independently associated with an increased risk of NAFLD in euthyroid patients with T2DM who had an HbA1c level≥ 7% or a BMI< 28 kg/m2.Conclusion: High-normal serum TSH levels are significantly associated with the presence of NAFLD in T2DM patients with euthyroid function, which provide novel insight for treating NAFLD.Keywords: non-alcoholic fatty liver disease, type 2 diabetes, thyroid hormoneTan YTang XMu PYang YLi MNie YLi HZhu YChen YDove Medical Pressarticlenon-alcoholic fatty liver disease,type 2 diabetesthyroid hormoneSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 2841-2849 (2021)
institution DOAJ
collection DOAJ
language EN
topic non-alcoholic fatty liver disease,type 2 diabetes
thyroid hormone
Specialties of internal medicine
RC581-951
spellingShingle non-alcoholic fatty liver disease,type 2 diabetes
thyroid hormone
Specialties of internal medicine
RC581-951
Tan Y
Tang X
Mu P
Yang Y
Li M
Nie Y
Li H
Zhu Y
Chen Y
High-Normal Serum Thyrotropin Levels Increased the Risk of Non-Alcoholic Fatty Liver Disease in Euthyroid Subjects with Type 2 Diabetes
description Ying Tan,1,* Xixiang Tang,1,2,* Panwei Mu,1 Yi Yang,1 Mei Li,1,2 Yuanpeng Nie,1 Haicheng Li,1 Yanhua Zhu,1 Yanming Chen1 1Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, People’s Republic of China; 2VIP medical service center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanming Chen; Yanhua ZhuDepartment of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, Tianhe Road 600, Guangzhou, 510630, People’s Republic of ChinaEmail chyanm@mail.sysu.edu.cn; zhuyanh2@mail.sysu.edu.cnPurpose: The aim of this study was to investigate the association between high-normal thyrotropin (TSH) levels and the prevalence of non-alcoholic fatty liver disease (NAFLD) in euthyroid patients with T2DM.Methods: A total of 2289 euthyroid adults with T2DM were included in this cross-sectional study conducted at the Third Affiliated Hospital of Sun Yat-sen University from January 2016 to December 2018. NAFLD was diagnosed by abdominal ultrasound. Thyroid function parameters, including the levels of TSH, free triiodothyronine (FT3) and free thyroxine (FT4), were analyzed. The patients were stratified by quartiles (Q1-4) of TSH levels. Multivariate logistic regression models were used to evaluate the association between the quartiles of TSH levels and the risk of NAFLD in euthyroid adults with T2DM.Results: There were 940 (41.1%) euthyroid adults with T2DM who were diagnosed with NAFLD. The subjects were divided according to the thyroid function parameter quartiles. The prevalence of NAFLD increased with increasing TSH level quartiles (Q1 to Q4: 34.8%, 37.5%, 44.9% and 47.0%, P< 0.01) but not with increasing FT3 or FT4 level quartiles. In the multivariate logistic regression model, compared with the lowest TSH level quartile (Q1), the highest TSH level quartile (Q4) (OR=1.610, 95% CI=1.131– 2.289, P=0.008) was independently associated with an increased risk of NAFLD in euthyroid adults with T2DM after adjusting for multiple confounders. After additional stratification by the level of glycosylated haemoglobin (HbA1c) and body mass index (BMI), the highest TSH level quartile was still independently associated with an increased risk of NAFLD in euthyroid patients with T2DM who had an HbA1c level≥ 7% or a BMI< 28 kg/m2.Conclusion: High-normal serum TSH levels are significantly associated with the presence of NAFLD in T2DM patients with euthyroid function, which provide novel insight for treating NAFLD.Keywords: non-alcoholic fatty liver disease, type 2 diabetes, thyroid hormone
format article
author Tan Y
Tang X
Mu P
Yang Y
Li M
Nie Y
Li H
Zhu Y
Chen Y
author_facet Tan Y
Tang X
Mu P
Yang Y
Li M
Nie Y
Li H
Zhu Y
Chen Y
author_sort Tan Y
title High-Normal Serum Thyrotropin Levels Increased the Risk of Non-Alcoholic Fatty Liver Disease in Euthyroid Subjects with Type 2 Diabetes
title_short High-Normal Serum Thyrotropin Levels Increased the Risk of Non-Alcoholic Fatty Liver Disease in Euthyroid Subjects with Type 2 Diabetes
title_full High-Normal Serum Thyrotropin Levels Increased the Risk of Non-Alcoholic Fatty Liver Disease in Euthyroid Subjects with Type 2 Diabetes
title_fullStr High-Normal Serum Thyrotropin Levels Increased the Risk of Non-Alcoholic Fatty Liver Disease in Euthyroid Subjects with Type 2 Diabetes
title_full_unstemmed High-Normal Serum Thyrotropin Levels Increased the Risk of Non-Alcoholic Fatty Liver Disease in Euthyroid Subjects with Type 2 Diabetes
title_sort high-normal serum thyrotropin levels increased the risk of non-alcoholic fatty liver disease in euthyroid subjects with type 2 diabetes
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/cee5608a5c80428b8c44f22b05ea56f0
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