Possible associations between antioxidant enzyme polymorphisms and metabolic abnormalities in patients with schizophrenia

Junji Saruwatari,1,* Norio Yasui-Furukori,2,* Ryoko Kamihashi,1 Yuki Yoshimori,1 Kentaro Oniki,1 Shoko Tsuchimine,2 Madoka Noai,1 Yasushi Sato,3 Taku Nakagami,4 Norio Sugawara,2 Manabu Saito,2 Akira Fujii,2 Ayami Kajiwara,1 Shuichi Mihara,5 Yasuhiro Ogata,6 Sunao Kaneko,2 Kazuko Nakagawa1,71Division...

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Autores principales:	Saruwatari J, Yasui-Furukori N, Kamihashi R, Yoshimori Y, Oniki K, Tsuchimine S, Noai M, Sato Y, Nakagami T, Sugawara N, Saito M, Fujii A, Kajiwara A, Mihara S, Ogata Y, Kaneko S, Nakagawa K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/cee60d7ed93f49f5909d1b29a02253da
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spelling	oai:doaj.org-article:cee60d7ed93f49f5909d1b29a02253da2021-12-02T05:04:44ZPossible associations between antioxidant enzyme polymorphisms and metabolic abnormalities in patients with schizophrenia1176-63281178-2021https://doaj.org/article/cee60d7ed93f49f5909d1b29a02253da2013-11-01T00:00:00Zhttp://www.dovepress.com/possible-associations-between-antioxidant-enzyme-polymorphisms-and-met-a14872https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Junji Saruwatari,1,* Norio Yasui-Furukori,2,* Ryoko Kamihashi,1 Yuki Yoshimori,1 Kentaro Oniki,1 Shoko Tsuchimine,2 Madoka Noai,1 Yasushi Sato,3 Taku Nakagami,4 Norio Sugawara,2 Manabu Saito,2 Akira Fujii,2 Ayami Kajiwara,1 Shuichi Mihara,5 Yasuhiro Ogata,6 Sunao Kaneko,2 Kazuko Nakagawa1,71Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 2Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, 3Department of Psychiatry, Hirosaki Aiseikai Hospital, Hirosaki, 4Department of Psychiatry, Odate Municipal General Hospital, Odate, 5Mihara Life Care Clinic, Kumamoto, 6Japanese Red Cross Kumamoto Health Care Center, Kumamoto, 7Center for Clinical Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan*These authors contributed equally to this paperBackground: This study investigated the possible association between common and potentially functional polymorphisms of antioxidant enzymes and metabolic abnormalities in patients with schizophrenia.Methods: The possible associations of the glutathione S-transferase (GST) M1 null and GSTT1 null genotypes, and the superoxide dismutase 2 (SOD2) Val16Ala polymorphism with the risks of being overweight and having metabolic syndrome were examined using a logistic regression analysis in 154 schizophrenic Japanese patients and 203 controls.Results: Among smokers with schizophrenia, the risks of being overweight and having decreased high-density lipoprotein cholesterol were significantly higher in those with the GSTM1 null genotype than in those with the present genotype (odds ratio 3.20 and 3.15, P=0.03 and P=0.04, respectively), while among nonsmokers with schizophrenia, the risk of an abnormal waist circumference was lower in those with the GSTM1 null genotype (odds ratio 0.34, P=0.04). The risk of a decreased high-density lipoprotein cholesterol level was significantly higher in patients with the combined GSTM1 null and GSTT1 present genotypes than in those with the present genotypes of both genes (odds ratio 3.60, P<0.01). The SOD2 Val16Ala polymorphism was not associated with risk of metabolic abnormalities in either group.Conclusion: The present study suggests that the GSTM1 null genotype, in combination with smoking status or GSTT1 genotype, might be associated with the metabolic abnormalities in patients with schizophrenia.Keywords: schizophrenia, metabolic syndrome, oxidative stress, glutathione S-transferase, superoxide dismutase 2, polymorphismSaruwatari JYasui-Furukori NKamihashi RYoshimori YOniki KTsuchimine SNoai MSato YNakagami TSugawara NSaito MFujii AKajiwara AMihara SOgata YKaneko SNakagawa KDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 1683-1698 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Saruwatari J Yasui-Furukori N Kamihashi R Yoshimori Y Oniki K Tsuchimine S Noai M Sato Y Nakagami T Sugawara N Saito M Fujii A Kajiwara A Mihara S Ogata Y Kaneko S Nakagawa K Possible associations between antioxidant enzyme polymorphisms and metabolic abnormalities in patients with schizophrenia
description	Junji Saruwatari,1,* Norio Yasui-Furukori,2,* Ryoko Kamihashi,1 Yuki Yoshimori,1 Kentaro Oniki,1 Shoko Tsuchimine,2 Madoka Noai,1 Yasushi Sato,3 Taku Nakagami,4 Norio Sugawara,2 Manabu Saito,2 Akira Fujii,2 Ayami Kajiwara,1 Shuichi Mihara,5 Yasuhiro Ogata,6 Sunao Kaneko,2 Kazuko Nakagawa1,71Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 2Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, 3Department of Psychiatry, Hirosaki Aiseikai Hospital, Hirosaki, 4Department of Psychiatry, Odate Municipal General Hospital, Odate, 5Mihara Life Care Clinic, Kumamoto, 6Japanese Red Cross Kumamoto Health Care Center, Kumamoto, 7Center for Clinical Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan*These authors contributed equally to this paperBackground: This study investigated the possible association between common and potentially functional polymorphisms of antioxidant enzymes and metabolic abnormalities in patients with schizophrenia.Methods: The possible associations of the glutathione S-transferase (GST) M1 null and GSTT1 null genotypes, and the superoxide dismutase 2 (SOD2) Val16Ala polymorphism with the risks of being overweight and having metabolic syndrome were examined using a logistic regression analysis in 154 schizophrenic Japanese patients and 203 controls.Results: Among smokers with schizophrenia, the risks of being overweight and having decreased high-density lipoprotein cholesterol were significantly higher in those with the GSTM1 null genotype than in those with the present genotype (odds ratio 3.20 and 3.15, P=0.03 and P=0.04, respectively), while among nonsmokers with schizophrenia, the risk of an abnormal waist circumference was lower in those with the GSTM1 null genotype (odds ratio 0.34, P=0.04). The risk of a decreased high-density lipoprotein cholesterol level was significantly higher in patients with the combined GSTM1 null and GSTT1 present genotypes than in those with the present genotypes of both genes (odds ratio 3.60, P<0.01). The SOD2 Val16Ala polymorphism was not associated with risk of metabolic abnormalities in either group.Conclusion: The present study suggests that the GSTM1 null genotype, in combination with smoking status or GSTT1 genotype, might be associated with the metabolic abnormalities in patients with schizophrenia.Keywords: schizophrenia, metabolic syndrome, oxidative stress, glutathione S-transferase, superoxide dismutase 2, polymorphism
format	article
author	Saruwatari J Yasui-Furukori N Kamihashi R Yoshimori Y Oniki K Tsuchimine S Noai M Sato Y Nakagami T Sugawara N Saito M Fujii A Kajiwara A Mihara S Ogata Y Kaneko S Nakagawa K
author_facet	Saruwatari J Yasui-Furukori N Kamihashi R Yoshimori Y Oniki K Tsuchimine S Noai M Sato Y Nakagami T Sugawara N Saito M Fujii A Kajiwara A Mihara S Ogata Y Kaneko S Nakagawa K
author_sort	Saruwatari J
title	Possible associations between antioxidant enzyme polymorphisms and metabolic abnormalities in patients with schizophrenia
title_short	Possible associations between antioxidant enzyme polymorphisms and metabolic abnormalities in patients with schizophrenia
title_full	Possible associations between antioxidant enzyme polymorphisms and metabolic abnormalities in patients with schizophrenia
title_fullStr	Possible associations between antioxidant enzyme polymorphisms and metabolic abnormalities in patients with schizophrenia
title_full_unstemmed	Possible associations between antioxidant enzyme polymorphisms and metabolic abnormalities in patients with schizophrenia
title_sort	possible associations between antioxidant enzyme polymorphisms and metabolic abnormalities in patients with schizophrenia
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/cee60d7ed93f49f5909d1b29a02253da
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Possible associations between antioxidant enzyme polymorphisms and metabolic abnormalities in patients with schizophrenia

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