Bone marrow-derived mesenchymal stromal cell: what next?

Fernanda T Borges,1,2 Marcia Bastos Convento,1 Nestor Schor1,&dagger; 1Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil; 2Interdisciplinary Postgraduate Program in Health Sciences, Universidade Cruzeiro do Sul, S&atil...

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Autores principales:	Borges FT, Convento MB, Schor N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	mesenchymal stromal cells secretome extracellular vesicles microRNAS lipids growth factor Cytology QH573-671
Acceso en línea:	https://doaj.org/article/cee61d0d25c04c96aba85e63f08f5c35
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spelling	oai:doaj.org-article:cee61d0d25c04c96aba85e63f08f5c352021-12-02T03:21:16ZBone marrow-derived mesenchymal stromal cell: what next?1178-6957https://doaj.org/article/cee61d0d25c04c96aba85e63f08f5c352018-11-01T00:00:00Zhttps://www.dovepress.com/bone-marrow-derived-mesenchymal-stromal-cell-what-next-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Fernanda T Borges,1,2 Marcia Bastos Convento,1 Nestor Schor1,&dagger; 1Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil; 2Interdisciplinary Postgraduate Program in Health Sciences, Universidade Cruzeiro do Sul, São Paulo, SP, Brazil &dagger;Professor Nestor Schor passed away on February 2, 2018 Abstract: Bone marrow mesenchymal stromal cell (MSC) is a potential alternative in regenerative medicine and has great potential in many pathologic conditions including kidney disease. Although most of the studies demonstrate MSC efficiency, the regenerative potential may not be efficient in all diseases and patients. Stem cell feasibility is modified by donor characteristics as gender, age, diet, and health status, producing both positive and negative results. The conditioning of MSC can potentiate its effects and modify its culture medium (CM). In current practices, the cell-free treatment is gaining notable attention, while MSC-conditioned CM is being applied and studied in many experimental diseases, including, but not limited to, certain kidney diseases. This may be the next step for clinical trials. Studies in stem cell CM have focused mainly on extracellular vesicles, nucleic acids (mRNA and microRNA), lipids, and proteins presented in this CM. They mediate regenerative effects of MSC in a harmonic manner. In this review, we will analyze the regenerative potential of MSC and its CM as well as discuss some effective techniques for modifying its fractions and improving its therapeutic potential. CM fractions may be modified by hypoxic conditions, inflammation, lipid exposition, and protein growth factors. Other possible mechanisms of action of stem cells are also suggested. In the future, the MSC paracrine effect may be modified to more closely meet each patient’s needs. Keywords: mesenchymal stromal cells, secretome, extracellular vesicles, microRNAs, lipids, growth factorBorges FTConvento MBSchor NDove Medical Pressarticlemesenchymal stromal cellssecretomeextracellular vesiclesmicroRNASlipidsgrowth factorCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol Volume 11, Pp 77-83 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesenchymal stromal cells secretome extracellular vesicles microRNAS lipids growth factor Cytology QH573-671
spellingShingle	mesenchymal stromal cells secretome extracellular vesicles microRNAS lipids growth factor Cytology QH573-671 Borges FT Convento MB Schor N Bone marrow-derived mesenchymal stromal cell: what next?
description	Fernanda T Borges,1,2 Marcia Bastos Convento,1 Nestor Schor1,&dagger; 1Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil; 2Interdisciplinary Postgraduate Program in Health Sciences, Universidade Cruzeiro do Sul, São Paulo, SP, Brazil &dagger;Professor Nestor Schor passed away on February 2, 2018 Abstract: Bone marrow mesenchymal stromal cell (MSC) is a potential alternative in regenerative medicine and has great potential in many pathologic conditions including kidney disease. Although most of the studies demonstrate MSC efficiency, the regenerative potential may not be efficient in all diseases and patients. Stem cell feasibility is modified by donor characteristics as gender, age, diet, and health status, producing both positive and negative results. The conditioning of MSC can potentiate its effects and modify its culture medium (CM). In current practices, the cell-free treatment is gaining notable attention, while MSC-conditioned CM is being applied and studied in many experimental diseases, including, but not limited to, certain kidney diseases. This may be the next step for clinical trials. Studies in stem cell CM have focused mainly on extracellular vesicles, nucleic acids (mRNA and microRNA), lipids, and proteins presented in this CM. They mediate regenerative effects of MSC in a harmonic manner. In this review, we will analyze the regenerative potential of MSC and its CM as well as discuss some effective techniques for modifying its fractions and improving its therapeutic potential. CM fractions may be modified by hypoxic conditions, inflammation, lipid exposition, and protein growth factors. Other possible mechanisms of action of stem cells are also suggested. In the future, the MSC paracrine effect may be modified to more closely meet each patient’s needs. Keywords: mesenchymal stromal cells, secretome, extracellular vesicles, microRNAs, lipids, growth factor
format	article
author	Borges FT Convento MB Schor N
author_facet	Borges FT Convento MB Schor N
author_sort	Borges FT
title	Bone marrow-derived mesenchymal stromal cell: what next?
title_short	Bone marrow-derived mesenchymal stromal cell: what next?
title_full	Bone marrow-derived mesenchymal stromal cell: what next?
title_fullStr	Bone marrow-derived mesenchymal stromal cell: what next?
title_full_unstemmed	Bone marrow-derived mesenchymal stromal cell: what next?
title_sort	bone marrow-derived mesenchymal stromal cell: what next?
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/cee61d0d25c04c96aba85e63f08f5c35
work_keys_str_mv	AT borgesft bonemarrowderivedmesenchymalstromalcellwhatnext AT conventomb bonemarrowderivedmesenchymalstromalcellwhatnext AT schorn bonemarrowderivedmesenchymalstromalcellwhatnext
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Bone marrow-derived mesenchymal stromal cell: what next?

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