The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β.

The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β.

It is currently unknown how mucosal adjuvants cause induction of secretory immunoglobulin A (IgA), and how T cell-dependent (TD) or -independent (TI) pathways might be involved. Mucosal dendritic cells (DCs) are the primary antigen presenting cells driving TI IgA synthesis, by producing a proliferat...

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Main Authors: Anouk K Gloudemans, Maud Plantinga, Martin Guilliams, Monique A Willart, Arifa Ozir-Fazalalikhan, Alwin van der Ham, Louis Boon, Nicola L Harris, Hamida Hammad, Henk C Hoogsteden, Maria Yazdanbakhsh, Rudi W Hendriks, Bart N Lambrecht, Hermelijn H Smits
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/cee7ddb13e3e45cfbe33652d910078eb
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