HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition

UPF1 is a central protein in nonsense-mediated mRNA decay (NMD), but contribution of its RNA processivity to NMD is unclear. Here, the authors show how the retroviral Tax protein interacts with and inhibits UPF1, and demonstrate that UPF1’s translocase activity contributes to NMD.

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Autores principales:	Francesca Fiorini, Jean-Philippe Robin, Joanne Kanaan, Malgorzata Borowiak, Vincent Croquette, Hervé Le Hir, Pierre Jalinot, Vincent Mocquet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cee99c9cf6b9423fa0e3aee0a205c4f9
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spelling	oai:doaj.org-article:cee99c9cf6b9423fa0e3aee0a205c4f92021-12-02T17:31:46ZHTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition10.1038/s41467-017-02793-62041-1723https://doaj.org/article/cee99c9cf6b9423fa0e3aee0a205c4f92018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02793-6https://doaj.org/toc/2041-1723UPF1 is a central protein in nonsense-mediated mRNA decay (NMD), but contribution of its RNA processivity to NMD is unclear. Here, the authors show how the retroviral Tax protein interacts with and inhibits UPF1, and demonstrate that UPF1’s translocase activity contributes to NMD.Francesca FioriniJean-Philippe RobinJoanne KanaanMalgorzata BorowiakVincent CroquetteHervé Le HirPierre JalinotVincent MocquetNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Francesca Fiorini Jean-Philippe Robin Joanne Kanaan Malgorzata Borowiak Vincent Croquette Hervé Le Hir Pierre Jalinot Vincent Mocquet HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition
description	UPF1 is a central protein in nonsense-mediated mRNA decay (NMD), but contribution of its RNA processivity to NMD is unclear. Here, the authors show how the retroviral Tax protein interacts with and inhibits UPF1, and demonstrate that UPF1’s translocase activity contributes to NMD.
format	article
author	Francesca Fiorini Jean-Philippe Robin Joanne Kanaan Malgorzata Borowiak Vincent Croquette Hervé Le Hir Pierre Jalinot Vincent Mocquet
author_facet	Francesca Fiorini Jean-Philippe Robin Joanne Kanaan Malgorzata Borowiak Vincent Croquette Hervé Le Hir Pierre Jalinot Vincent Mocquet
author_sort	Francesca Fiorini
title	HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition
title_short	HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition
title_full	HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition
title_fullStr	HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition
title_full_unstemmed	HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition
title_sort	htlv-1 tax plugs and freezes upf1 helicase leading to nonsense-mediated mrna decay inhibition
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cee99c9cf6b9423fa0e3aee0a205c4f9
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HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition

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