Simple low dose radiography allows precise lung volume assessment in mice
Abstract X-ray based lung function (XLF) as a planar method uses dramatically less X-ray dose than computed tomography (CT) but so far lacked the ability to relate its parameters to pulmonary air volume. The purpose of this study was to calibrate the functional constituents of XLF that are biomedica...
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Nature Portfolio
2021
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oai:doaj.org-article:ceea1a46388e43879f7803acbb7f1a292021-12-02T14:04:39ZSimple low dose radiography allows precise lung volume assessment in mice10.1038/s41598-021-83319-52045-2322https://doaj.org/article/ceea1a46388e43879f7803acbb7f1a292021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83319-5https://doaj.org/toc/2045-2322Abstract X-ray based lung function (XLF) as a planar method uses dramatically less X-ray dose than computed tomography (CT) but so far lacked the ability to relate its parameters to pulmonary air volume. The purpose of this study was to calibrate the functional constituents of XLF that are biomedically decipherable and directly comparable to that of micro-CT and whole-body plethysmography (WBP). Here, we developed a unique set-up for simultaneous assessment of lung function and volume using XLF, micro-CT and WBP on healthy mice. Our results reveal a strong correlation of lung volumes obtained from radiographic XLF and micro-CT and demonstrate that XLF is superior to WBP in sensitivity and precision to assess lung volumes. Importantly, XLF measurement uses only a fraction of the radiation dose and acquisition time required for CT. Therefore, the redefined XLF approach is a promising tool for preclinical longitudinal studies with a substantial potential of clinical translation.Amara KhanAndrea MarkusThomas RittmannJonas AlbersFrauke AlvesSwen HülsmannChristian DullinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
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Medicine R Science Q Amara Khan Andrea Markus Thomas Rittmann Jonas Albers Frauke Alves Swen Hülsmann Christian Dullin Simple low dose radiography allows precise lung volume assessment in mice |
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Abstract X-ray based lung function (XLF) as a planar method uses dramatically less X-ray dose than computed tomography (CT) but so far lacked the ability to relate its parameters to pulmonary air volume. The purpose of this study was to calibrate the functional constituents of XLF that are biomedically decipherable and directly comparable to that of micro-CT and whole-body plethysmography (WBP). Here, we developed a unique set-up for simultaneous assessment of lung function and volume using XLF, micro-CT and WBP on healthy mice. Our results reveal a strong correlation of lung volumes obtained from radiographic XLF and micro-CT and demonstrate that XLF is superior to WBP in sensitivity and precision to assess lung volumes. Importantly, XLF measurement uses only a fraction of the radiation dose and acquisition time required for CT. Therefore, the redefined XLF approach is a promising tool for preclinical longitudinal studies with a substantial potential of clinical translation. |
format |
article |
author |
Amara Khan Andrea Markus Thomas Rittmann Jonas Albers Frauke Alves Swen Hülsmann Christian Dullin |
author_facet |
Amara Khan Andrea Markus Thomas Rittmann Jonas Albers Frauke Alves Swen Hülsmann Christian Dullin |
author_sort |
Amara Khan |
title |
Simple low dose radiography allows precise lung volume assessment in mice |
title_short |
Simple low dose radiography allows precise lung volume assessment in mice |
title_full |
Simple low dose radiography allows precise lung volume assessment in mice |
title_fullStr |
Simple low dose radiography allows precise lung volume assessment in mice |
title_full_unstemmed |
Simple low dose radiography allows precise lung volume assessment in mice |
title_sort |
simple low dose radiography allows precise lung volume assessment in mice |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/ceea1a46388e43879f7803acbb7f1a29 |
work_keys_str_mv |
AT amarakhan simplelowdoseradiographyallowspreciselungvolumeassessmentinmice AT andreamarkus simplelowdoseradiographyallowspreciselungvolumeassessmentinmice AT thomasrittmann simplelowdoseradiographyallowspreciselungvolumeassessmentinmice AT jonasalbers simplelowdoseradiographyallowspreciselungvolumeassessmentinmice AT fraukealves simplelowdoseradiographyallowspreciselungvolumeassessmentinmice AT swenhulsmann simplelowdoseradiographyallowspreciselungvolumeassessmentinmice AT christiandullin simplelowdoseradiographyallowspreciselungvolumeassessmentinmice |
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1718392050742722560 |