Neoadjuvant immunotherapy combined with chemotherapy for locally advanced squamous cell lung carcinoma: A case report and literature review

The benefit of immunochemotherapy in treating resectable locally advanced non-small cell lung cancer (NSCLC) is not well established. Here, we report a case of resectable stage III NSCLC treated with neoadjuvant immunotherapy combined with chemotherapy before surgery. A 61 years old man was admitted...

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Autores principales:	Zheng Yuan, Zhu Wei, Huang Xinjie, Lin Dongqun, Lin Yu
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	durvalumab chemotherapy neoadjuvant immunotherapy locally advanced resectable nsclc case report Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cef4b757c5844e30ab016ce38b309643
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spelling	oai:doaj.org-article:cef4b757c5844e30ab016ce38b3096432021-12-05T14:10:41ZNeoadjuvant immunotherapy combined with chemotherapy for locally advanced squamous cell lung carcinoma: A case report and literature review2391-541210.1515/biol-2021-0083https://doaj.org/article/cef4b757c5844e30ab016ce38b3096432021-08-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0083https://doaj.org/toc/2391-5412The benefit of immunochemotherapy in treating resectable locally advanced non-small cell lung cancer (NSCLC) is not well established. Here, we report a case of resectable stage III NSCLC treated with neoadjuvant immunotherapy combined with chemotherapy before surgery. A 61 years old man was admitted to our hospital due to paroxysmal cough and was diagnosed as squamous cell carcinoma T4N2M0 in the upper lobe of the right lung, which was locally advanced and resectable. He was treated with 3 courses of paclitaxel 250 mg intravenous (IV), carboplatin 0.65 g IV, and durvalumab 620 mg IV followed by thoracoscopic upper lobectomy and lymph node dissection. There was considerable regression of the tumor before surgery, and the patient achieved a complete pathological response after surgery. Our case study demonstrates the benefit of durvalumab and chemotherapy in the treatment of resectable locally advanced NSCLC.Zheng YuanZhu WeiHuang XinjieLin DongqunLin YuDe Gruyterarticledurvalumabchemotherapyneoadjuvant immunotherapylocally advanced resectable nsclccase reportBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 838-844 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	durvalumab chemotherapy neoadjuvant immunotherapy locally advanced resectable nsclc case report Biology (General) QH301-705.5
spellingShingle	durvalumab chemotherapy neoadjuvant immunotherapy locally advanced resectable nsclc case report Biology (General) QH301-705.5 Zheng Yuan Zhu Wei Huang Xinjie Lin Dongqun Lin Yu Neoadjuvant immunotherapy combined with chemotherapy for locally advanced squamous cell lung carcinoma: A case report and literature review
description	The benefit of immunochemotherapy in treating resectable locally advanced non-small cell lung cancer (NSCLC) is not well established. Here, we report a case of resectable stage III NSCLC treated with neoadjuvant immunotherapy combined with chemotherapy before surgery. A 61 years old man was admitted to our hospital due to paroxysmal cough and was diagnosed as squamous cell carcinoma T4N2M0 in the upper lobe of the right lung, which was locally advanced and resectable. He was treated with 3 courses of paclitaxel 250 mg intravenous (IV), carboplatin 0.65 g IV, and durvalumab 620 mg IV followed by thoracoscopic upper lobectomy and lymph node dissection. There was considerable regression of the tumor before surgery, and the patient achieved a complete pathological response after surgery. Our case study demonstrates the benefit of durvalumab and chemotherapy in the treatment of resectable locally advanced NSCLC.
format	article
author	Zheng Yuan Zhu Wei Huang Xinjie Lin Dongqun Lin Yu
author_facet	Zheng Yuan Zhu Wei Huang Xinjie Lin Dongqun Lin Yu
author_sort	Zheng Yuan
title	Neoadjuvant immunotherapy combined with chemotherapy for locally advanced squamous cell lung carcinoma: A case report and literature review
title_short	Neoadjuvant immunotherapy combined with chemotherapy for locally advanced squamous cell lung carcinoma: A case report and literature review
title_full	Neoadjuvant immunotherapy combined with chemotherapy for locally advanced squamous cell lung carcinoma: A case report and literature review
title_fullStr	Neoadjuvant immunotherapy combined with chemotherapy for locally advanced squamous cell lung carcinoma: A case report and literature review
title_full_unstemmed	Neoadjuvant immunotherapy combined with chemotherapy for locally advanced squamous cell lung carcinoma: A case report and literature review
title_sort	neoadjuvant immunotherapy combined with chemotherapy for locally advanced squamous cell lung carcinoma: a case report and literature review
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/cef4b757c5844e30ab016ce38b309643
work_keys_str_mv	AT zhengyuan neoadjuvantimmunotherapycombinedwithchemotherapyforlocallyadvancedsquamouscelllungcarcinomaacasereportandliteraturereview AT zhuwei neoadjuvantimmunotherapycombinedwithchemotherapyforlocallyadvancedsquamouscelllungcarcinomaacasereportandliteraturereview AT huangxinjie neoadjuvantimmunotherapycombinedwithchemotherapyforlocallyadvancedsquamouscelllungcarcinomaacasereportandliteraturereview AT lindongqun neoadjuvantimmunotherapycombinedwithchemotherapyforlocallyadvancedsquamouscelllungcarcinomaacasereportandliteraturereview AT linyu neoadjuvantimmunotherapycombinedwithchemotherapyforlocallyadvancedsquamouscelllungcarcinomaacasereportandliteraturereview
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Neoadjuvant immunotherapy combined with chemotherapy for locally advanced squamous cell lung carcinoma: A case report and literature review

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