A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines
In 2021 the scientific community’s efforts have been focused on solving the back-breaking challenge of the COVID-19 pandemic, but sexually transmitted infections (STI) are still one of the most common global health problems. Syphilis is a systemic disease caused by the spirochaete Treponema pallidum...
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MDPI AG
2021
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oai:doaj.org-article:cef58efeb07b4662b4f2f7061d2d732d2021-11-25T18:37:38ZA 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines10.3390/pathogens101113642076-0817https://doaj.org/article/cef58efeb07b4662b4f2f7061d2d732d2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1364https://doaj.org/toc/2076-0817In 2021 the scientific community’s efforts have been focused on solving the back-breaking challenge of the COVID-19 pandemic, but sexually transmitted infections (STI) are still one of the most common global health problems. Syphilis is a systemic disease caused by the spirochaete Treponema pallidum (TP) and is one of the oldest known diseases. Its incidence has increased in the last few years and syphilis still remains a contemporary plague that continues to afflict millions of people worldwide. Despite research improvements, syphilis pathogenesis is not completely clear; clinical presentation is very heterogeneous and the diagnosis can sometimes be difficult. Furthermore, few therapeutic options are available, and a vaccine has not been found yet. In this review, we describe the most recent evidence concerning the clinical manifestation, diagnosis, treatment and vaccine prospectives for this disease.Giorgio TieccoMelania Degli AntoniSamuele StortiValentina MarcheseEmanuele FocàCarlo TortiFrancesco CastelliEugenia Quiros-RoldanMDPI AGarticlesyphilissexually transmitted infectionsHIV infectionpathogenesisvaccineMedicineRENPathogens, Vol 10, Iss 1364, p 1364 (2021) |
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syphilis sexually transmitted infections HIV infection pathogenesis vaccine Medicine R |
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syphilis sexually transmitted infections HIV infection pathogenesis vaccine Medicine R Giorgio Tiecco Melania Degli Antoni Samuele Storti Valentina Marchese Emanuele Focà Carlo Torti Francesco Castelli Eugenia Quiros-Roldan A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines |
| description |
In 2021 the scientific community’s efforts have been focused on solving the back-breaking challenge of the COVID-19 pandemic, but sexually transmitted infections (STI) are still one of the most common global health problems. Syphilis is a systemic disease caused by the spirochaete Treponema pallidum (TP) and is one of the oldest known diseases. Its incidence has increased in the last few years and syphilis still remains a contemporary plague that continues to afflict millions of people worldwide. Despite research improvements, syphilis pathogenesis is not completely clear; clinical presentation is very heterogeneous and the diagnosis can sometimes be difficult. Furthermore, few therapeutic options are available, and a vaccine has not been found yet. In this review, we describe the most recent evidence concerning the clinical manifestation, diagnosis, treatment and vaccine prospectives for this disease. |
| format |
article |
| author |
Giorgio Tiecco Melania Degli Antoni Samuele Storti Valentina Marchese Emanuele Focà Carlo Torti Francesco Castelli Eugenia Quiros-Roldan |
| author_facet |
Giorgio Tiecco Melania Degli Antoni Samuele Storti Valentina Marchese Emanuele Focà Carlo Torti Francesco Castelli Eugenia Quiros-Roldan |
| author_sort |
Giorgio Tiecco |
| title |
A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines |
| title_short |
A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines |
| title_full |
A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines |
| title_fullStr |
A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines |
| title_full_unstemmed |
A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines |
| title_sort |
2021 update on syphilis: taking stock from pathogenesis to vaccines |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/cef58efeb07b4662b4f2f7061d2d732d |
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