Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders

Chrysin, a herbal bioactive molecule, exerts a plethora of pharmacological effects, including anti-oxidant, anti-inflammatory, neuroprotective, and anti-cancer. A growing body of evidence has highlighted the emerging role of chrysin in a variety of neurological disorders, including Alzheimer’s and P...

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Autores principales:	Awanish Mishra, Pragya Shakti Mishra, Ritam Bandopadhyay, Navneet Khurana, Efthalia Angelopoulou, Yam Nath Paudel, Christina Piperi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chrysin antioxidant neuroprotective agents neurological disorders epilepsy neurodegenerative diseases Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/cef9d7ef2d5f49399ddb25f1ee360125
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id	oai:doaj.org-article:cef9d7ef2d5f49399ddb25f1ee360125
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spelling	oai:doaj.org-article:cef9d7ef2d5f49399ddb25f1ee3601252021-11-11T18:27:56ZNeuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders10.3390/molecules262164561420-3049https://doaj.org/article/cef9d7ef2d5f49399ddb25f1ee3601252021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6456https://doaj.org/toc/1420-3049Chrysin, a herbal bioactive molecule, exerts a plethora of pharmacological effects, including anti-oxidant, anti-inflammatory, neuroprotective, and anti-cancer. A growing body of evidence has highlighted the emerging role of chrysin in a variety of neurological disorders, including Alzheimer’s and Parkinson’s disease, epilepsy, multiple sclerosis, ischemic stroke, traumatic brain injury, and brain tumors. Based on the results of recent pre-clinical studies and evidence from studies in humans, this review is focused on the molecular mechanisms underlying the neuroprotective effects of chrysin in different neurological diseases. In addition, the potential challenges, and opportunities of chrysin’s inclusion in the neurotherapeutics repertoire are critically discussed.Awanish MishraPragya Shakti MishraRitam BandopadhyayNavneet KhuranaEfthalia AngelopoulouYam Nath PaudelChristina PiperiMDPI AGarticlechrysinantioxidantneuroprotective agentsneurological disordersepilepsyneurodegenerative diseasesOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6456, p 6456 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chrysin antioxidant neuroprotective agents neurological disorders epilepsy neurodegenerative diseases Organic chemistry QD241-441
spellingShingle	chrysin antioxidant neuroprotective agents neurological disorders epilepsy neurodegenerative diseases Organic chemistry QD241-441 Awanish Mishra Pragya Shakti Mishra Ritam Bandopadhyay Navneet Khurana Efthalia Angelopoulou Yam Nath Paudel Christina Piperi Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders
description	Chrysin, a herbal bioactive molecule, exerts a plethora of pharmacological effects, including anti-oxidant, anti-inflammatory, neuroprotective, and anti-cancer. A growing body of evidence has highlighted the emerging role of chrysin in a variety of neurological disorders, including Alzheimer’s and Parkinson’s disease, epilepsy, multiple sclerosis, ischemic stroke, traumatic brain injury, and brain tumors. Based on the results of recent pre-clinical studies and evidence from studies in humans, this review is focused on the molecular mechanisms underlying the neuroprotective effects of chrysin in different neurological diseases. In addition, the potential challenges, and opportunities of chrysin’s inclusion in the neurotherapeutics repertoire are critically discussed.
format	article
author	Awanish Mishra Pragya Shakti Mishra Ritam Bandopadhyay Navneet Khurana Efthalia Angelopoulou Yam Nath Paudel Christina Piperi
author_facet	Awanish Mishra Pragya Shakti Mishra Ritam Bandopadhyay Navneet Khurana Efthalia Angelopoulou Yam Nath Paudel Christina Piperi
author_sort	Awanish Mishra
title	Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders
title_short	Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders
title_full	Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders
title_fullStr	Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders
title_full_unstemmed	Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders
title_sort	neuroprotective potential of chrysin: mechanistic insights and therapeutic potential for neurological disorders
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cef9d7ef2d5f49399ddb25f1ee360125
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Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders

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