Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity

Bariatric surgery is the only procedure to obtain and maintain weight loss in the long term, although the mechanisms driving these benefits are not completely understood. In the last years, gut microbiota has emerged as one of the drivers through its metabolites, especially secondary bile acids. In...

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Autores principales:	Luis Ocaña-Wilhelmi, Gracia María Martín-Núñez, Patricia Ruiz-Limón, Juan Alcaide, Eduardo García-Fuentes, Carolina Gutiérrez-Repiso, Francisco J. Tinahones, Isabel Moreno-Indias
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bile acids bariatric surgery gut microbiota Enterobacteriaceae Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/cefc9a4a2d51419ab4fc4dccaadffc81
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spelling	oai:doaj.org-article:cefc9a4a2d51419ab4fc4dccaadffc812021-11-25T18:20:31ZGut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity10.3390/metabo111107332218-1989https://doaj.org/article/cefc9a4a2d51419ab4fc4dccaadffc812021-10-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/733https://doaj.org/toc/2218-1989Bariatric surgery is the only procedure to obtain and maintain weight loss in the long term, although the mechanisms driving these benefits are not completely understood. In the last years, gut microbiota has emerged as one of the drivers through its metabolites, especially secondary bile acids. In the current study, we have compared the gut microbiota and the bile acid pool, as well as anthropometric and biochemical parameters, of patient with morbid obesity who underwent bariatric surgery by two different techniques, namely Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). Gut microbiota populations differed after the respective procedures, particularly with respect to the <i>Enterobacteriaceae</i> family. Both techniques resulted in changes in the bile acids pool, but RYGB was the procedure which suffered the greatest changes, with a reduction in most of their levels. <i>Blautia</i> and <i>Veillonella</i> were the two genera that more relationships showed with secondary bile acids, indicating a possible role in their formation and inhibition, respectively. Correlations with the anthropometric and biochemical variables showed that secondary bile acids could have a role in the amelioration of the glucose and HDL-cholesterol levels. Thus, we have observed a possible relationship between the interaction of the bile acids pool metabolized by the gut microbiota in the metabolic improvements obtained by bariatric surgery in the frame of morbid obesity, deserving further investigation in greater cohorts to decipher the role of each bile acid in the homeostasis of the host for their possible use in the development of microbiota-based therapeutics, such as new drugs, postbiotics or probiotics.Luis Ocaña-WilhelmiGracia María Martín-NúñezPatricia Ruiz-LimónJuan AlcaideEduardo García-FuentesCarolina Gutiérrez-RepisoFrancisco J. TinahonesIsabel Moreno-IndiasMDPI AGarticlebile acidsbariatric surgerygut microbiotaEnterobacteriaceaeMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 733, p 733 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bile acids bariatric surgery gut microbiota Enterobacteriaceae Microbiology QR1-502
spellingShingle	bile acids bariatric surgery gut microbiota Enterobacteriaceae Microbiology QR1-502 Luis Ocaña-Wilhelmi Gracia María Martín-Núñez Patricia Ruiz-Limón Juan Alcaide Eduardo García-Fuentes Carolina Gutiérrez-Repiso Francisco J. Tinahones Isabel Moreno-Indias Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
description	Bariatric surgery is the only procedure to obtain and maintain weight loss in the long term, although the mechanisms driving these benefits are not completely understood. In the last years, gut microbiota has emerged as one of the drivers through its metabolites, especially secondary bile acids. In the current study, we have compared the gut microbiota and the bile acid pool, as well as anthropometric and biochemical parameters, of patient with morbid obesity who underwent bariatric surgery by two different techniques, namely Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). Gut microbiota populations differed after the respective procedures, particularly with respect to the <i>Enterobacteriaceae</i> family. Both techniques resulted in changes in the bile acids pool, but RYGB was the procedure which suffered the greatest changes, with a reduction in most of their levels. <i>Blautia</i> and <i>Veillonella</i> were the two genera that more relationships showed with secondary bile acids, indicating a possible role in their formation and inhibition, respectively. Correlations with the anthropometric and biochemical variables showed that secondary bile acids could have a role in the amelioration of the glucose and HDL-cholesterol levels. Thus, we have observed a possible relationship between the interaction of the bile acids pool metabolized by the gut microbiota in the metabolic improvements obtained by bariatric surgery in the frame of morbid obesity, deserving further investigation in greater cohorts to decipher the role of each bile acid in the homeostasis of the host for their possible use in the development of microbiota-based therapeutics, such as new drugs, postbiotics or probiotics.
format	article
author	Luis Ocaña-Wilhelmi Gracia María Martín-Núñez Patricia Ruiz-Limón Juan Alcaide Eduardo García-Fuentes Carolina Gutiérrez-Repiso Francisco J. Tinahones Isabel Moreno-Indias
author_facet	Luis Ocaña-Wilhelmi Gracia María Martín-Núñez Patricia Ruiz-Limón Juan Alcaide Eduardo García-Fuentes Carolina Gutiérrez-Repiso Francisco J. Tinahones Isabel Moreno-Indias
author_sort	Luis Ocaña-Wilhelmi
title	Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
title_short	Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
title_full	Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
title_fullStr	Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
title_full_unstemmed	Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
title_sort	gut microbiota metabolism of bile acids could contribute to the bariatric surgery improvements in extreme obesity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cefc9a4a2d51419ab4fc4dccaadffc81
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Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity

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