Characterization and analysis of the antidiabetic activities of sulphated polysaccharide extract from Caulerpa lentillifera

Caulerpa lentillifera is a type of green seaweed that is cultivated in tropical and subtropical areas. The objectives of this study were to determine the characteristics of the sulfated polysaccharides from C. lentillifera and evaluate its antidiabetic activity. In the initial process of this study,...

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Autores principales:	Sofa Fajriah, Ilmi Fadhilah Rizki, Ellya Sinurat
Formato:	article
Lenguaje:	EN
Publicado:	Pensoft Publishers 2021
Materias:	Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/ceff6b948a2a400895b6d791b5082748
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spelling	oai:doaj.org-article:ceff6b948a2a400895b6d791b50827482021-11-14T04:30:20ZCharacterization and analysis of the antidiabetic activities of sulphated polysaccharide extract from Caulerpa lentillifera10.3897/pharmacia.68.e731582603-557Xhttps://doaj.org/article/ceff6b948a2a400895b6d791b50827482021-11-01T00:00:00Zhttps://pharmacia.pensoft.net/article/73158/download/pdf/https://pharmacia.pensoft.net/article/73158/download/xml/https://pharmacia.pensoft.net/article/73158/https://doaj.org/toc/2603-557XCaulerpa lentillifera is a type of green seaweed that is cultivated in tropical and subtropical areas. The objectives of this study were to determine the characteristics of the sulfated polysaccharides from C. lentillifera and evaluate its antidiabetic activity. In the initial process of this study, samples were macerated with ethanol (1:10). Then, the maceration residue was extracted with an accumulator at 75 °C for three hours. The crude extract yield was 4.16% based on weight seaweed. Ion chromatography purification with DEAE-Sepharose resin provided a yield of 14.8% of crude extract. The monomer analysis of C. lentillifera from the crude extract and purified extract revealed that galactose monomers were dominant and glucose was a minor component. The total carbohydrate and sulfate contents of purified C. lentillifera were higher than those of crude C. lentillifera. Bioactivity tests revealed that purified polysaccharides had higher antidiabetic activity against α-glucosidase enzyme than crude ones with IC50 values of 134.81± 2.0 µg/mL. Purified sulfated polysaccharides of C. lentillifera could potentially be used as an antidiabetic medication.Sofa FajriahIlmi Fadhilah RizkiEllya SinuratPensoft PublishersarticlePharmacy and materia medicaRS1-441ENPharmacia, Vol 68, Iss 4, Pp 869-875 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pharmacy and materia medica RS1-441
spellingShingle	Pharmacy and materia medica RS1-441 Sofa Fajriah Ilmi Fadhilah Rizki Ellya Sinurat Characterization and analysis of the antidiabetic activities of sulphated polysaccharide extract from Caulerpa lentillifera
description	Caulerpa lentillifera is a type of green seaweed that is cultivated in tropical and subtropical areas. The objectives of this study were to determine the characteristics of the sulfated polysaccharides from C. lentillifera and evaluate its antidiabetic activity. In the initial process of this study, samples were macerated with ethanol (1:10). Then, the maceration residue was extracted with an accumulator at 75 °C for three hours. The crude extract yield was 4.16% based on weight seaweed. Ion chromatography purification with DEAE-Sepharose resin provided a yield of 14.8% of crude extract. The monomer analysis of C. lentillifera from the crude extract and purified extract revealed that galactose monomers were dominant and glucose was a minor component. The total carbohydrate and sulfate contents of purified C. lentillifera were higher than those of crude C. lentillifera. Bioactivity tests revealed that purified polysaccharides had higher antidiabetic activity against α-glucosidase enzyme than crude ones with IC50 values of 134.81± 2.0 µg/mL. Purified sulfated polysaccharides of C. lentillifera could potentially be used as an antidiabetic medication.
format	article
author	Sofa Fajriah Ilmi Fadhilah Rizki Ellya Sinurat
author_facet	Sofa Fajriah Ilmi Fadhilah Rizki Ellya Sinurat
author_sort	Sofa Fajriah
title	Characterization and analysis of the antidiabetic activities of sulphated polysaccharide extract from Caulerpa lentillifera
title_short	Characterization and analysis of the antidiabetic activities of sulphated polysaccharide extract from Caulerpa lentillifera
title_full	Characterization and analysis of the antidiabetic activities of sulphated polysaccharide extract from Caulerpa lentillifera
title_fullStr	Characterization and analysis of the antidiabetic activities of sulphated polysaccharide extract from Caulerpa lentillifera
title_full_unstemmed	Characterization and analysis of the antidiabetic activities of sulphated polysaccharide extract from Caulerpa lentillifera
title_sort	characterization and analysis of the antidiabetic activities of sulphated polysaccharide extract from caulerpa lentillifera
publisher	Pensoft Publishers
publishDate	2021
url	https://doaj.org/article/ceff6b948a2a400895b6d791b5082748
work_keys_str_mv	AT sofafajriah characterizationandanalysisoftheantidiabeticactivitiesofsulphatedpolysaccharideextractfromcaulerpalentillifera AT ilmifadhilahrizki characterizationandanalysisoftheantidiabeticactivitiesofsulphatedpolysaccharideextractfromcaulerpalentillifera AT ellyasinurat characterizationandanalysisoftheantidiabeticactivitiesofsulphatedpolysaccharideextractfromcaulerpalentillifera
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Characterization and analysis of the antidiabetic activities of sulphated polysaccharide extract from Caulerpa lentillifera

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