Evidence of the first clinical case of equine neuroinvasive West Nile disease in Serbia, 2018

During July 2018, the first clinical case of neurological West Nile virus (WNV) infection was reported in a Belgian sports mare in Belgrade, Serbia. Typical symptoms, such as hypersensitive skin reaction, disorientation, weakness, ataxia and the loss of equilibrium were reported. Detection of WNV Ig...

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Autores principales:	Medić Strahinja, Lazić Sava, Petrović Tamaš, Petrić Dušan, Samojlović Milena, Lazić Gospava, Lupulović Diana
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2019
Materias:	west nile virus neuroinvasive disease horses serbia Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/cf009c1003964e428da951254202b72c
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spelling	oai:doaj.org-article:cf009c1003964e428da951254202b72c2021-11-17T21:27:53ZEvidence of the first clinical case of equine neuroinvasive West Nile disease in Serbia, 20181820-744810.2478/acve-2019-0009https://doaj.org/article/cf009c1003964e428da951254202b72c2019-03-01T00:00:00Zhttps://doi.org/10.2478/acve-2019-0009https://doaj.org/toc/1820-7448During July 2018, the first clinical case of neurological West Nile virus (WNV) infection was reported in a Belgian sports mare in Belgrade, Serbia. Typical symptoms, such as hypersensitive skin reaction, disorientation, weakness, ataxia and the loss of equilibrium were reported. Detection of WNV IgM antibodies by commercial ELISA in the serum samples of the diseased mare strongly indicated acute infection. The ELISA positive results were confirmed by VNT. Hematological and biochemical parameters were in the reference range. The only finding was a minor lymphopenia. WNV RNA was not detected by RT-qPCR in the blood sample extracted seven days after the disease had broken out. The horse improved clinically in two weeks while other horses at the same premises remained asymptomatic. The clinical, serological, biochemical and molecular analyses applied confirmed the first clinical case of neuroinvasive WNV infection in horses in Serbia. The West Nile virus has been circulating in Serbia in the last decade in mosquitoes, birds, and horses, but no evidence of equine WNV clinical cases were registered so far.Medić StrahinjaLazić SavaPetrović TamašPetrić DušanSamojlović MilenaLazić GospavaLupulović DianaSciendoarticlewest nile virusneuroinvasive diseasehorsesserbiaVeterinary medicineSF600-1100ENActa Veterinaria, Vol 69, Iss 1, Pp 123-130 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	west nile virus neuroinvasive disease horses serbia Veterinary medicine SF600-1100
spellingShingle	west nile virus neuroinvasive disease horses serbia Veterinary medicine SF600-1100 Medić Strahinja Lazić Sava Petrović Tamaš Petrić Dušan Samojlović Milena Lazić Gospava Lupulović Diana Evidence of the first clinical case of equine neuroinvasive West Nile disease in Serbia, 2018
description	During July 2018, the first clinical case of neurological West Nile virus (WNV) infection was reported in a Belgian sports mare in Belgrade, Serbia. Typical symptoms, such as hypersensitive skin reaction, disorientation, weakness, ataxia and the loss of equilibrium were reported. Detection of WNV IgM antibodies by commercial ELISA in the serum samples of the diseased mare strongly indicated acute infection. The ELISA positive results were confirmed by VNT. Hematological and biochemical parameters were in the reference range. The only finding was a minor lymphopenia. WNV RNA was not detected by RT-qPCR in the blood sample extracted seven days after the disease had broken out. The horse improved clinically in two weeks while other horses at the same premises remained asymptomatic. The clinical, serological, biochemical and molecular analyses applied confirmed the first clinical case of neuroinvasive WNV infection in horses in Serbia. The West Nile virus has been circulating in Serbia in the last decade in mosquitoes, birds, and horses, but no evidence of equine WNV clinical cases were registered so far.
format	article
author	Medić Strahinja Lazić Sava Petrović Tamaš Petrić Dušan Samojlović Milena Lazić Gospava Lupulović Diana
author_facet	Medić Strahinja Lazić Sava Petrović Tamaš Petrić Dušan Samojlović Milena Lazić Gospava Lupulović Diana
author_sort	Medić Strahinja
title	Evidence of the first clinical case of equine neuroinvasive West Nile disease in Serbia, 2018
title_short	Evidence of the first clinical case of equine neuroinvasive West Nile disease in Serbia, 2018
title_full	Evidence of the first clinical case of equine neuroinvasive West Nile disease in Serbia, 2018
title_fullStr	Evidence of the first clinical case of equine neuroinvasive West Nile disease in Serbia, 2018
title_full_unstemmed	Evidence of the first clinical case of equine neuroinvasive West Nile disease in Serbia, 2018
title_sort	evidence of the first clinical case of equine neuroinvasive west nile disease in serbia, 2018
publisher	Sciendo
publishDate	2019
url	https://doaj.org/article/cf009c1003964e428da951254202b72c
work_keys_str_mv	AT medicstrahinja evidenceofthefirstclinicalcaseofequineneuroinvasivewestnilediseaseinserbia2018 AT lazicsava evidenceofthefirstclinicalcaseofequineneuroinvasivewestnilediseaseinserbia2018 AT petrovictamas evidenceofthefirstclinicalcaseofequineneuroinvasivewestnilediseaseinserbia2018 AT petricdusan evidenceofthefirstclinicalcaseofequineneuroinvasivewestnilediseaseinserbia2018 AT samojlovicmilena evidenceofthefirstclinicalcaseofequineneuroinvasivewestnilediseaseinserbia2018 AT lazicgospava evidenceofthefirstclinicalcaseofequineneuroinvasivewestnilediseaseinserbia2018 AT lupulovicdiana evidenceofthefirstclinicalcaseofequineneuroinvasivewestnilediseaseinserbia2018
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Evidence of the first clinical case of equine neuroinvasive West Nile disease in Serbia, 2018

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