The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study

The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study

Yue Li,1 Man Li,2 Lei Yang,1 Wei Qin,1 Shuna Yang,1 Junliang Yuan,1 Tao Jiang,2 Wenli Hu11Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University,...

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Autores principales: Li Y, Li M, Yang L, Qin W, Yang S, Yuan J, Jiang T, Hu W
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
Enlarged perivascular spaces
Cerebral small vessel disease
Blood-brain barrier
Dynamic contrast-enhanced (DCE)-Magnetic Resonance Imaging (MRI).
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/cf00e3256b5940feb209a61d7c73fccb
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spelling oai:doaj.org-article:cf00e3256b5940feb209a61d7c73fccb2021-12-02T13:18:24ZThe relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study1178-1998https://doaj.org/article/cf00e3256b5940feb209a61d7c73fccb2019-05-01T00:00:00Zhttps://www.dovepress.com/the-relationship-between-blood-brain-barrier-permeability-and-enlarged-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Yue Li,1 Man Li,2 Lei Yang,1 Wei Qin,1 Shuna Yang,1 Junliang Yuan,1 Tao Jiang,2 Wenli Hu11Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of ChinaPurpose: Enlarged perivascular spaces (EPVS) have been widely considered as a feature of cerebral small vessel disease (cSVD) but the pathogenesis of EPVS remains unclear. Compromised blood–brain barrier (BBB) integrity may play a role since previous studies have shown that BBB breakdown is a critical contributor to the pathogenesis of other cSVD markers. This study aimed to investigate the association of EPVS in the centrum semiovale (CSO) and basal ganglia (BG) with BBB permeability.Patients and methods: Consecutive participants free of symptomatic stroke history presented for physical examination were enrolled in this cross-sectional study. CSO- and BG-EPVS on T2-weighted (T2-W) magnetic resonance imaging (MRI) were rated using a five-point validated scale. Dynamic contrast-enhanced (DCE)-MRI and Patlak pharmacokinetic model were applied to quantify BBB permeability in the CSO and BG.Results: A total of 109 participants aged 49–90 years (mean age of 69.85 years) were enrolled. The proportions of participants presenting high-grade (>10) EPVS in the CSO and BG were 50.5% and 44.0%, respectively. After adjustments for potential confounders by logistic regression, leakage rate and fractional blood plasma volume were correlated with the severity of BG-EPVS (OR: 5.33; 95%CI: 1.95–14.60 and OR: 0.93; 95%CI: 0.87–0.99).Conclusion: Our study demonstrates that BG-EPVS are associated with compromised BBB integrity, supporting the hypothesis that the BBB dysfunction may be involved in the pathogenesis of BG-EPVS. EPVS in the CSO and BG may have distinct pathophysiology.Keywords: enlarged perivascular spaces, cerebral small vessel disease, blood–brain barrier, dynamic contrast-enhanced, DCE, magnetic resonance imaging, MRILi YLi MYang LQin WYang SYuan JJiang THu WDove Medical PressarticleEnlarged perivascular spacesCerebral small vessel diseaseBlood-brain barrierDynamic contrast-enhanced (DCE)-Magnetic Resonance Imaging (MRI).GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 871-878 (2019)
institution DOAJ
collection DOAJ
language EN
topic Enlarged perivascular spaces
Cerebral small vessel disease
Blood-brain barrier
Dynamic contrast-enhanced (DCE)-Magnetic Resonance Imaging (MRI).
Geriatrics
RC952-954.6
spellingShingle Enlarged perivascular spaces
Cerebral small vessel disease
Blood-brain barrier
Dynamic contrast-enhanced (DCE)-Magnetic Resonance Imaging (MRI).
Geriatrics
RC952-954.6
Li Y
Li M
Yang L
Qin W
Yang S
Yuan J
Jiang T
Hu W
The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study
description Yue Li,1 Man Li,2 Lei Yang,1 Wei Qin,1 Shuna Yang,1 Junliang Yuan,1 Tao Jiang,2 Wenli Hu11Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of ChinaPurpose: Enlarged perivascular spaces (EPVS) have been widely considered as a feature of cerebral small vessel disease (cSVD) but the pathogenesis of EPVS remains unclear. Compromised blood–brain barrier (BBB) integrity may play a role since previous studies have shown that BBB breakdown is a critical contributor to the pathogenesis of other cSVD markers. This study aimed to investigate the association of EPVS in the centrum semiovale (CSO) and basal ganglia (BG) with BBB permeability.Patients and methods: Consecutive participants free of symptomatic stroke history presented for physical examination were enrolled in this cross-sectional study. CSO- and BG-EPVS on T2-weighted (T2-W) magnetic resonance imaging (MRI) were rated using a five-point validated scale. Dynamic contrast-enhanced (DCE)-MRI and Patlak pharmacokinetic model were applied to quantify BBB permeability in the CSO and BG.Results: A total of 109 participants aged 49–90 years (mean age of 69.85 years) were enrolled. The proportions of participants presenting high-grade (>10) EPVS in the CSO and BG were 50.5% and 44.0%, respectively. After adjustments for potential confounders by logistic regression, leakage rate and fractional blood plasma volume were correlated with the severity of BG-EPVS (OR: 5.33; 95%CI: 1.95–14.60 and OR: 0.93; 95%CI: 0.87–0.99).Conclusion: Our study demonstrates that BG-EPVS are associated with compromised BBB integrity, supporting the hypothesis that the BBB dysfunction may be involved in the pathogenesis of BG-EPVS. EPVS in the CSO and BG may have distinct pathophysiology.Keywords: enlarged perivascular spaces, cerebral small vessel disease, blood–brain barrier, dynamic contrast-enhanced, DCE, magnetic resonance imaging, MRI
format article
author Li Y
Li M
Yang L
Qin W
Yang S
Yuan J
Jiang T
Hu W
author_facet Li Y
Li M
Yang L
Qin W
Yang S
Yuan J
Jiang T
Hu W
author_sort Li Y
title The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study
title_short The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study
title_full The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study
title_fullStr The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study
title_full_unstemmed The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study
title_sort relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/cf00e3256b5940feb209a61d7c73fccb
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