A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings

Johan Källstrand,1 Tommy Lewander,2 Eva Baghdassarian,2,3 Sören Nielzén4 1SensoDetect AB, Lund, 2Department of Neuroscience, Medical Faculty, Uppsala University, 3Department of Psychiatry, Uppsala University Hospital, Uppsala, 4Department of Psychiatry, Medical Faculty,...

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Autores principales:	Källstr, J, Lewander T, Baghdassarian E, Nielzén S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/cf022191fada4313bf8efa6fa634e1e9
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spelling	oai:doaj.org-article:cf022191fada4313bf8efa6fa634e1e92021-12-02T07:42:14ZA new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings1178-2021https://doaj.org/article/cf022191fada4313bf8efa6fa634e1e92014-06-01T00:00:00Zhttp://www.dovepress.com/a-new-method-for-analyzing-auditory-brain-stem-response-waveforms-usin-a17137https://doaj.org/toc/1178-2021 Johan Källstrand,1 Tommy Lewander,2 Eva Baghdassarian,2,3 Sören Nielzén4 1SensoDetect AB, Lund, 2Department of Neuroscience, Medical Faculty, Uppsala University, 3Department of Psychiatry, Uppsala University Hospital, Uppsala, 4Department of Psychiatry, Medical Faculty, University of Lund, Lund, Sweden Abstract: The auditory brain-stem response (ABR) waveform comprises a set of waves (labeled I–VII) recorded with scalp electrodes over 10 ms after an auditory stimulation with a brief click sound. Quite often, the waves are fused (confluent) and baseline-irregular and sloped, making wave latencies and wave amplitudes difficult to establish. In the present paper, we describe a method, labeled moving-minimum subtraction, based on digitization of the analog ABR waveform (154 data points/ms) in order to achieve alignment of the ABR response to a straight baseline, often with clear baseline separation of waves and resolution of fused waves. Application of the new method to groups of patients showed marked differences in ABR waveforms between patients with schizophrenia versus patients with adult attention deficit/hyperactivity disorder versus healthy controls. The findings show promise regarding the possibility to identify ABR markers to be used as biomarkers as support for clinical diagnoses of these and other neuropsychiatric disorders. Keywords: auditory brain-stem response, digitization, moving-minimum subtraction method, baseline alignment, schizophrenia, ADHDKällstrJLewander TBaghdassarian ENielzén SDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1011-1016 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Källstr J Lewander T Baghdassarian E Nielzén S A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings
description	Johan Källstrand,1 Tommy Lewander,2 Eva Baghdassarian,2,3 Sören Nielzén4 1SensoDetect AB, Lund, 2Department of Neuroscience, Medical Faculty, Uppsala University, 3Department of Psychiatry, Uppsala University Hospital, Uppsala, 4Department of Psychiatry, Medical Faculty, University of Lund, Lund, Sweden Abstract: The auditory brain-stem response (ABR) waveform comprises a set of waves (labeled I–VII) recorded with scalp electrodes over 10 ms after an auditory stimulation with a brief click sound. Quite often, the waves are fused (confluent) and baseline-irregular and sloped, making wave latencies and wave amplitudes difficult to establish. In the present paper, we describe a method, labeled moving-minimum subtraction, based on digitization of the analog ABR waveform (154 data points/ms) in order to achieve alignment of the ABR response to a straight baseline, often with clear baseline separation of waves and resolution of fused waves. Application of the new method to groups of patients showed marked differences in ABR waveforms between patients with schizophrenia versus patients with adult attention deficit/hyperactivity disorder versus healthy controls. The findings show promise regarding the possibility to identify ABR markers to be used as biomarkers as support for clinical diagnoses of these and other neuropsychiatric disorders. Keywords: auditory brain-stem response, digitization, moving-minimum subtraction method, baseline alignment, schizophrenia, ADHD
format	article
author	Källstr J Lewander T Baghdassarian E Nielzén S
author_facet	Källstr J Lewander T Baghdassarian E Nielzén S
author_sort	Källstr
title	A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings
title_short	A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings
title_full	A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings
title_fullStr	A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings
title_full_unstemmed	A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings
title_sort	new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/cf022191fada4313bf8efa6fa634e1e9
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A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings

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