Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats.

<h4>Background</h4>There has been a dramatic escalation in sugar intake in the last few decades, most strikingly observed in the adolescent population. Sugar overconsumption has been associated with several adverse health consequences, including obesity and diabetes. Very little is known...

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Autores principales:	Leandro F Vendruscolo, Aliou B Gueye, Muriel Darnaudéry, Serge H Ahmed, Martine Cador
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf04fa9b80b74ec8ba185c8850e624e3
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spelling	oai:doaj.org-article:cf04fa9b80b74ec8ba185c8850e624e32021-11-25T06:25:41ZSugar overconsumption during adolescence selectively alters motivation and reward function in adult rats.1932-620310.1371/journal.pone.0009296https://doaj.org/article/cf04fa9b80b74ec8ba185c8850e624e32010-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20174565/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>There has been a dramatic escalation in sugar intake in the last few decades, most strikingly observed in the adolescent population. Sugar overconsumption has been associated with several adverse health consequences, including obesity and diabetes. Very little is known, however, about the impact of sugar overconsumption on mental health in general, and on reward-related behavioral disorders in particular. This study examined in rats the effects of unlimited access to sucrose during adolescence on the motivation for natural and pharmacological rewards in adulthood.<h4>Methodology/principal findings</h4>Adolescent rats had free access to 5% sucrose or water from postnatal day 30 to 46. The control group had access to water only. In adulthood, rats were tested for self-administration of saccharin (sweet), maltodextrin (non-sweet), and cocaine (a potent drug of abuse) using fixed- and progressive-ratio schedules, and a concentration-response curve for each substance. Adult rats, exposed or not exposed to sucrose, were tested for saccharin self-administration later in life to verify the specificity of adolescence for the sugar effects. Sugar overconsumption during adolescence, but not during adulthood, reduced the subsequent motivation for saccharin and maltodextrin, but not cocaine. This selective decrease in motivation is more likely due to changes in brain reward processing than changes in gustatory perception.<h4>Conclusions/significance</h4>Sugar overconsumption induces a developmental stage-specific chronic depression in reward processing that may contribute to an increase in the vulnerability to reward-related psychiatric disorders.Leandro F VendruscoloAliou B GueyeMuriel DarnaudérySerge H AhmedMartine CadorPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 2, p e9296 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leandro F Vendruscolo Aliou B Gueye Muriel Darnaudéry Serge H Ahmed Martine Cador Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats.
description	<h4>Background</h4>There has been a dramatic escalation in sugar intake in the last few decades, most strikingly observed in the adolescent population. Sugar overconsumption has been associated with several adverse health consequences, including obesity and diabetes. Very little is known, however, about the impact of sugar overconsumption on mental health in general, and on reward-related behavioral disorders in particular. This study examined in rats the effects of unlimited access to sucrose during adolescence on the motivation for natural and pharmacological rewards in adulthood.<h4>Methodology/principal findings</h4>Adolescent rats had free access to 5% sucrose or water from postnatal day 30 to 46. The control group had access to water only. In adulthood, rats were tested for self-administration of saccharin (sweet), maltodextrin (non-sweet), and cocaine (a potent drug of abuse) using fixed- and progressive-ratio schedules, and a concentration-response curve for each substance. Adult rats, exposed or not exposed to sucrose, were tested for saccharin self-administration later in life to verify the specificity of adolescence for the sugar effects. Sugar overconsumption during adolescence, but not during adulthood, reduced the subsequent motivation for saccharin and maltodextrin, but not cocaine. This selective decrease in motivation is more likely due to changes in brain reward processing than changes in gustatory perception.<h4>Conclusions/significance</h4>Sugar overconsumption induces a developmental stage-specific chronic depression in reward processing that may contribute to an increase in the vulnerability to reward-related psychiatric disorders.
format	article
author	Leandro F Vendruscolo Aliou B Gueye Muriel Darnaudéry Serge H Ahmed Martine Cador
author_facet	Leandro F Vendruscolo Aliou B Gueye Muriel Darnaudéry Serge H Ahmed Martine Cador
author_sort	Leandro F Vendruscolo
title	Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats.
title_short	Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats.
title_full	Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats.
title_fullStr	Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats.
title_full_unstemmed	Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats.
title_sort	sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/cf04fa9b80b74ec8ba185c8850e624e3
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Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats.

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