Dissociable neural systems for timing: evidence from subjects with basal ganglia lesions.

<h4>Background</h4>The neural basis of timing remains poorly understood. Although controversy persists, many lines of evidence, including studies in animals, functional imaging studies in humans and lesion studies in humans and animals suggest that the basal ganglia are important for tem...

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Autores principales:	H Branch Coslett, Martin Wiener, Anjan Chatterjee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf05c734113b42528a6530ceae340710
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spelling	oai:doaj.org-article:cf05c734113b42528a6530ceae3407102021-12-02T20:22:10ZDissociable neural systems for timing: evidence from subjects with basal ganglia lesions.1932-620310.1371/journal.pone.0010324https://doaj.org/article/cf05c734113b42528a6530ceae3407102010-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20428244/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The neural basis of timing remains poorly understood. Although controversy persists, many lines of evidence, including studies in animals, functional imaging studies in humans and lesion studies in humans and animals suggest that the basal ganglia are important for temporal processing [1].<h4>Methodology/principal findings</h4>We report data from a wide range of timing tasks from two subjects with disabling neurologic deficits caused by bilateral lesions of the basal ganglia. Both subjects perform well on tasks assessing time estimation, reproduction and production tasks. Additionally, one subject performed normally on psychophysical tasks requiring the comparison of time intervals ranging from milliseconds to seconds; the second subject performed abnormally on the psychophysical task with a 300ms standard but did well with 600ms, 2000ms and 8000ms standards. Both subjects performed poorly on an isochronous rhythm production task on which they are required to maintain rhythmic tapping.<h4>Conclusions/significance</h4>As studies of subjects with brain lesions permit strong inferences regarding the necessity of brain structures, these data demonstrate that the basal ganglia are not crucial for many sub- or supra-second timing operations in humans but are needed for the timing procedures that underlie the production of movements. This dissociation suggests that distinct and dissociable processes may be employed to measure time intervals. Inconsistencies in findings regarding the neural basis of timing may reflect the availability of multiple temporal processing routines that are flexibly implemented in response to task demands.H Branch CoslettMartin WienerAnjan ChatterjeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 4, p e10324 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q H Branch Coslett Martin Wiener Anjan Chatterjee Dissociable neural systems for timing: evidence from subjects with basal ganglia lesions.
description	<h4>Background</h4>The neural basis of timing remains poorly understood. Although controversy persists, many lines of evidence, including studies in animals, functional imaging studies in humans and lesion studies in humans and animals suggest that the basal ganglia are important for temporal processing [1].<h4>Methodology/principal findings</h4>We report data from a wide range of timing tasks from two subjects with disabling neurologic deficits caused by bilateral lesions of the basal ganglia. Both subjects perform well on tasks assessing time estimation, reproduction and production tasks. Additionally, one subject performed normally on psychophysical tasks requiring the comparison of time intervals ranging from milliseconds to seconds; the second subject performed abnormally on the psychophysical task with a 300ms standard but did well with 600ms, 2000ms and 8000ms standards. Both subjects performed poorly on an isochronous rhythm production task on which they are required to maintain rhythmic tapping.<h4>Conclusions/significance</h4>As studies of subjects with brain lesions permit strong inferences regarding the necessity of brain structures, these data demonstrate that the basal ganglia are not crucial for many sub- or supra-second timing operations in humans but are needed for the timing procedures that underlie the production of movements. This dissociation suggests that distinct and dissociable processes may be employed to measure time intervals. Inconsistencies in findings regarding the neural basis of timing may reflect the availability of multiple temporal processing routines that are flexibly implemented in response to task demands.
format	article
author	H Branch Coslett Martin Wiener Anjan Chatterjee
author_facet	H Branch Coslett Martin Wiener Anjan Chatterjee
author_sort	H Branch Coslett
title	Dissociable neural systems for timing: evidence from subjects with basal ganglia lesions.
title_short	Dissociable neural systems for timing: evidence from subjects with basal ganglia lesions.
title_full	Dissociable neural systems for timing: evidence from subjects with basal ganglia lesions.
title_fullStr	Dissociable neural systems for timing: evidence from subjects with basal ganglia lesions.
title_full_unstemmed	Dissociable neural systems for timing: evidence from subjects with basal ganglia lesions.
title_sort	dissociable neural systems for timing: evidence from subjects with basal ganglia lesions.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/cf05c734113b42528a6530ceae340710
work_keys_str_mv	AT hbranchcoslett dissociableneuralsystemsfortimingevidencefromsubjectswithbasalganglialesions AT martinwiener dissociableneuralsystemsfortimingevidencefromsubjectswithbasalganglialesions AT anjanchatterjee dissociableneuralsystemsfortimingevidencefromsubjectswithbasalganglialesions
_version_	1718374134286647296

Dissociable neural systems for timing: evidence from subjects with basal ganglia lesions.

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