NK cell-like behavior of Valpha14i NK T cells during MCMV infection.

Immunity to the murine cytomegalovirus (MCMV) is critically dependent on the innate response for initial containment of viral replication, resolution of active infection, and proper induction of the adaptive phase of the anti-viral response. In contrast to NK cells, the Valpha14 invariant natural ki...

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Autores principales:	Johnna D Wesley, Marlowe S Tessmer, Deanna Chaukos, Laurent Brossay
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cf0c8f4b9ceb4e539891e22eb9329a32
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spelling	oai:doaj.org-article:cf0c8f4b9ceb4e539891e22eb9329a322021-11-25T05:46:30ZNK cell-like behavior of Valpha14i NK T cells during MCMV infection.1553-73661553-737410.1371/journal.ppat.1000106https://doaj.org/article/cf0c8f4b9ceb4e539891e22eb9329a322008-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18636102/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Immunity to the murine cytomegalovirus (MCMV) is critically dependent on the innate response for initial containment of viral replication, resolution of active infection, and proper induction of the adaptive phase of the anti-viral response. In contrast to NK cells, the Valpha14 invariant natural killer T cell response to MCMV has not been examined. We found that Valpha14i NK T cells become activated and produce significant levels of IFN-gamma, but do not proliferate or produce IL-4 following MCMV infection. In vivo treatment with an anti-CD1d mAb and adoptive transfer of Valpha14i NK T cells into MCMV-infected CD1d(-/-) mice demonstrate that CD1d is dispensable for Valpha14i NK T cell activation. In contrast, both IFN-alpha/beta and IL-12 are required for optimal activation. Valpha14i NK T cell-derived IFN-gamma is partially dependent on IFN-alpha/beta but highly dependent on IL-12. Valpha14i NK T cells contribute to the immune response to MCMV and amplify NK cell-derived IFN-gamma. Importantly, mortality is increased in CD1d(-/-) mice in response to high dose MCMV infection when compared to heterozygote littermate controls. Collectively, these findings illustrate the plasticity of Valpha14i NK T cells that act as effector T cells during bacterial infection, but have NK cell-like behavior during the innate immune response to MCMV infection.Johnna D WesleyMarlowe S TessmerDeanna ChaukosLaurent BrossayPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 4, Iss 7, p e1000106 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Johnna D Wesley Marlowe S Tessmer Deanna Chaukos Laurent Brossay NK cell-like behavior of Valpha14i NK T cells during MCMV infection.
description	Immunity to the murine cytomegalovirus (MCMV) is critically dependent on the innate response for initial containment of viral replication, resolution of active infection, and proper induction of the adaptive phase of the anti-viral response. In contrast to NK cells, the Valpha14 invariant natural killer T cell response to MCMV has not been examined. We found that Valpha14i NK T cells become activated and produce significant levels of IFN-gamma, but do not proliferate or produce IL-4 following MCMV infection. In vivo treatment with an anti-CD1d mAb and adoptive transfer of Valpha14i NK T cells into MCMV-infected CD1d(-/-) mice demonstrate that CD1d is dispensable for Valpha14i NK T cell activation. In contrast, both IFN-alpha/beta and IL-12 are required for optimal activation. Valpha14i NK T cell-derived IFN-gamma is partially dependent on IFN-alpha/beta but highly dependent on IL-12. Valpha14i NK T cells contribute to the immune response to MCMV and amplify NK cell-derived IFN-gamma. Importantly, mortality is increased in CD1d(-/-) mice in response to high dose MCMV infection when compared to heterozygote littermate controls. Collectively, these findings illustrate the plasticity of Valpha14i NK T cells that act as effector T cells during bacterial infection, but have NK cell-like behavior during the innate immune response to MCMV infection.
format	article
author	Johnna D Wesley Marlowe S Tessmer Deanna Chaukos Laurent Brossay
author_facet	Johnna D Wesley Marlowe S Tessmer Deanna Chaukos Laurent Brossay
author_sort	Johnna D Wesley
title	NK cell-like behavior of Valpha14i NK T cells during MCMV infection.
title_short	NK cell-like behavior of Valpha14i NK T cells during MCMV infection.
title_full	NK cell-like behavior of Valpha14i NK T cells during MCMV infection.
title_fullStr	NK cell-like behavior of Valpha14i NK T cells during MCMV infection.
title_full_unstemmed	NK cell-like behavior of Valpha14i NK T cells during MCMV infection.
title_sort	nk cell-like behavior of valpha14i nk t cells during mcmv infection.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/cf0c8f4b9ceb4e539891e22eb9329a32
work_keys_str_mv	AT johnnadwesley nkcelllikebehaviorofvalpha14inktcellsduringmcmvinfection AT marlowestessmer nkcelllikebehaviorofvalpha14inktcellsduringmcmvinfection AT deannachaukos nkcelllikebehaviorofvalpha14inktcellsduringmcmvinfection AT laurentbrossay nkcelllikebehaviorofvalpha14inktcellsduringmcmvinfection
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NK cell-like behavior of Valpha14i NK T cells during MCMV infection.

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