Participation of reactive oxygen species in the self-regulation of cardiac contractile function

The article analyzes various mechanisms of ROS participation in the processes that determine the response of automatism and cardiac contractile function under natural short- or long-term physiological stress, and acute disturbance of energy production in cardiomyocytes. Superoxide and hydrogen perox...

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Autor principal:	V. I. Kapelko
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	myocardium ionic transport automaticity mitochondria myofibrils sarcoplasmic reticulum hypoxia Science Q
Acceso en línea:	https://doaj.org/article/cf0e4a087d4d44e48469b6c1a8e9d639
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spelling	oai:doaj.org-article:cf0e4a087d4d44e48469b6c1a8e9d6392021-11-23T06:14:34ZParticipation of reactive oxygen species in the self-regulation of cardiac contractile function2541-94202587-959610.12737/article_590823a53d5e22.75029765https://doaj.org/article/cf0e4a087d4d44e48469b6c1a8e9d6392016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/210https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The article analyzes various mechanisms of ROS participation in the processes that determine the response of automatism and cardiac contractile function under natural short- or long-term physiological stress, and acute disturbance of energy production in cardiomyocytes. Superoxide and hydrogen peroxide are believed to have a similar effect, while the effect of nitroxide noticeably different. It was noted that increased CA++ in bioplasma not only enhances the contraction of myofibrils, but at the same time accelerates the rate of ATP synthesis. Regulation of volume load on the cellular level is realized by stretching of the sarcomeres, which increases the degree of actomyosin interaction. This corresponds to increase in the number of CA++ activators. Perhaps the formation of ROS in cardiomyocytes in response to stretching is a permanent and mandatory component of physiological responses that can synchronize the release of CA++ from SR and modulate its magnitude. However, in pathological conditions, overproduction of ROS can trigger arrhythmogenic CA++ waves. Some changes of DNA molecules under the influence of ROS may also be helpful to consolidate as a result of natural selection. Reactive oxygen species (ROS) are often considered as selected in the course of evolution as means of combating a variety of infections, but in the course of phylogeny they also were selected as a means of intracellular and extracellular exchange of information.V. I. KapelkoScientific Сentre for Family Health and Human Reproduction Problemsarticlemyocardiumionic transportautomaticitymitochondriamyofibrilssarcoplasmic reticulumhypoxiaScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(2), Pp 155-159 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	myocardium ionic transport automaticity mitochondria myofibrils sarcoplasmic reticulum hypoxia Science Q
spellingShingle	myocardium ionic transport automaticity mitochondria myofibrils sarcoplasmic reticulum hypoxia Science Q V. I. Kapelko Participation of reactive oxygen species in the self-regulation of cardiac contractile function
description	The article analyzes various mechanisms of ROS participation in the processes that determine the response of automatism and cardiac contractile function under natural short- or long-term physiological stress, and acute disturbance of energy production in cardiomyocytes. Superoxide and hydrogen peroxide are believed to have a similar effect, while the effect of nitroxide noticeably different. It was noted that increased CA++ in bioplasma not only enhances the contraction of myofibrils, but at the same time accelerates the rate of ATP synthesis. Regulation of volume load on the cellular level is realized by stretching of the sarcomeres, which increases the degree of actomyosin interaction. This corresponds to increase in the number of CA++ activators. Perhaps the formation of ROS in cardiomyocytes in response to stretching is a permanent and mandatory component of physiological responses that can synchronize the release of CA++ from SR and modulate its magnitude. However, in pathological conditions, overproduction of ROS can trigger arrhythmogenic CA++ waves. Some changes of DNA molecules under the influence of ROS may also be helpful to consolidate as a result of natural selection. Reactive oxygen species (ROS) are often considered as selected in the course of evolution as means of combating a variety of infections, but in the course of phylogeny they also were selected as a means of intracellular and extracellular exchange of information.
format	article
author	V. I. Kapelko
author_facet	V. I. Kapelko
author_sort	V. I. Kapelko
title	Participation of reactive oxygen species in the self-regulation of cardiac contractile function
title_short	Participation of reactive oxygen species in the self-regulation of cardiac contractile function
title_full	Participation of reactive oxygen species in the self-regulation of cardiac contractile function
title_fullStr	Participation of reactive oxygen species in the self-regulation of cardiac contractile function
title_full_unstemmed	Participation of reactive oxygen species in the self-regulation of cardiac contractile function
title_sort	participation of reactive oxygen species in the self-regulation of cardiac contractile function
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/cf0e4a087d4d44e48469b6c1a8e9d639
work_keys_str_mv	AT vikapelko participationofreactiveoxygenspeciesintheselfregulationofcardiaccontractilefunction
_version_	1718417098506502144

Participation of reactive oxygen species in the self-regulation of cardiac contractile function

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